In:
Mathematical Medicine and Biology: A Journal of the IMA, Oxford University Press (OUP), Vol. 39, No. 3 ( 2022-09-08), p. 299-312
Abstract:
This paper reports a minimal model simulating the growth of a Lewy body (LB). To the best of our knowledge, this is the first model simulating LB growth. The LB is assumed to consist of a central spherical core, which is composed of membrane fragments and various dysfunctional intracellular organelles, and a halo, which is composed of alpha-synuclein (α-syn) fibrils. Membrane fragments and α-syn monomers are assumed to be produced in the soma at constant rates. The growth of the core and the halo are simulated by the Finke–Watzky model. Analytical (closed-form) solutions describing the growth of the core and the halo are obtained. A sensitivity analysis in terms of model parameters is performed.
Type of Medium:
Online Resource
ISSN:
1477-8599
,
1477-8602
DOI:
10.1093/imammb/dqac006
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
2042047-X
SSG:
12
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