In:
Pediatrics, American Academy of Pediatrics (AAP), Vol. 124, No. 4 ( 2009-10-01), p. e615-e621
Abstract:
OBJECTIVE: The goal was to investigate the prevalence of renal and urinary tract anomalies (RUTAs) in a Down syndrome (DS) population. METHODS: Data were obtained from the New York State Congenital Malformation Registry (NYS-CMR) in this retrospective cohort study. The occurrence of RUTAs was assessed for children with and without DS who were born in NYS between 1992 and 2004. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each malformation. RESULTS: Between 1992 and 2004, 3832 children with DS and 3411833 without DS were born in NYS. The prevalence of RUTAs in the DS population was 3.2%, compared with 0.7% in the NYS population (OR: 4.5 [95% CI: 3.8–5.4]). Children with DS had significantly increased risks of anterior urethral obstruction (OR: 29.7 [95% CI: 4.0–217.7] ), cystic dysplastic kidney (OR: 4.5 [95% CI: 1.5–14.1]), hydronephrosis (OR: 8.7 [95% CI: 6.8–11.0] ), hydroureter (OR: 8.5 [95% CI: 3.5–20.4]), hypospadias (OR: 2.0 [95% CI: 1.4–2.9] ), posterior urethral valves (OR: 7.1 [95% CI: 1.8–28.8]), prune belly syndrome (OR: 11.9 [95% CI: 1.6–85.4] ), and renal agenesis (OR: 5.4 [95% CI: 2.8–10.4]). There was no significantly increased risk of ectopic kidney (OR: 1.6 [95% CI: 0.2–11.2] ) or ureteropelvic junction obstruction (OR: 1.4 [95% CI: 0.2–9.9]) in the DS population. CONCLUSION: Children with DS have significantly increased risks of RUTAs.
Type of Medium:
Online Resource
ISSN:
0031-4005
,
1098-4275
DOI:
10.1542/peds.2009-0181
Language:
English
Publisher:
American Academy of Pediatrics (AAP)
Publication Date:
2009
detail.hit.zdb_id:
1477004-0
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