In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-10), p. e0264915-
Abstract:
Taiwan has the highest prevalence of chronic kidney disease (CKD). Impaired cognition and quality of life are significant phenomena in the late stages of CKD. We sought to obtain an overview and the attributable effect of impaired glomerular filtration on multiple domains in cognition and dimensions of quality of life for community-based healthy older adults in Taiwan. Methods The study was derived from the Nutrition and Health Survey in Taiwan (NAHSIT) 2013–2016, a nationwide cross-sectional study conducted to sample healthy, community-based older adults aged ≥65 years in Taiwan. Participants were categorized into four CKD groups: CKD stage 1, stage 2, stages 3a and 3b, and stages 4–5. The Mini-Mental State Examination (MMSE) and the QoL questionnaire derived from the 12-item Short Form Health Survey (SF-12) were measured. Generalized linear mixed models (GLMMs) and principal component regressions were employed for the analysis and validation, respectively. Results Participants with moderate CKD (stages 3a and 3b) showed deficits in global MMSE, domain orientation to time, calculation, complex commands, and role-physical and vitality in QoL questionnaires. In GLMMs, impaired eGFR per 30 mL/min/1.73 m² was associated with lower global MMSE scores (β = -0.807, standard error [SE] = 0.235, P = 0.0007), domain orientation to time (β = -0.155, SE = 0.047, P = 0.0011), calculation (β = -0.338, SE = 0.109, P = 0.0020), complex commands (β = -0.156, SE = 0.079, P = 0.0494), and role-physical (β = -2.219, SE = 0.779, P = 0.0046) dimensions of QoL. Conclusions Elderly Han Chinese adults with moderately impaired renal filtration could manifest cognitive deficits in orientation to time, calculation, and impaired quality of life in physical role functioning.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0264915
DOI:
10.1371/journal.pone.0264915.g001
DOI:
10.1371/journal.pone.0264915.g002
DOI:
10.1371/journal.pone.0264915.g003
DOI:
10.1371/journal.pone.0264915.t001
DOI:
10.1371/journal.pone.0264915.t002
DOI:
10.1371/journal.pone.0264915.t003
DOI:
10.1371/journal.pone.0264915.t004
DOI:
10.1371/journal.pone.0264915.t005
DOI:
10.1371/journal.pone.0264915.s001
DOI:
10.1371/journal.pone.0264915.s002
DOI:
10.1371/journal.pone.0264915.s003
DOI:
10.1371/journal.pone.0264915.r001
DOI:
10.1371/journal.pone.0264915.r002
DOI:
10.1371/journal.pone.0264915.r003
DOI:
10.1371/journal.pone.0264915.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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