In:
Chirality, Wiley, Vol. 22, No. 1E ( 2010-01)
Abstract:
The compounds I–IV derived from α‐ D ‐cyclodextrin moiety by bridging and/or interconnecting with various patterns of disulfide bonds were chosen as models for the spectroscopic study of conformation of the disulfide bridge. The energy gap between the disulfide and cyclodextrin's electronic transitions allows us to investigate absorption and electronic circular dichroism spectra without disturbing spectral overlaps with amides or aromatic amino acids in peptides or proteins. Raman optical activity (ROA) spectra were measured and the bands due to SS and CS stretching motion identified. Comparison with the quantum mechanical calculations of simple models indicates that sense of disulfide twist follows sign of the measured SS ROA band. Chirality 2010. © 2010 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0899-0042
,
1520-636X
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2001237-8
SSG:
12
SSG:
15,3
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