In:
Australian and New Zealand Journal of Obstetrics and Gynaecology, Wiley, Vol. 58, No. 5 ( 2018-10), p. 576-581
Kurzfassung:
Papua New Guinea (PNG) has among the highest estimated burdens of cervical cancer globally but currently has no national cervical screening program. Visual inspection of the cervix with acetic acid ( VIA ) is a low‐cost screening strategy endorsed by the World Health Organization that has been adopted in many low‐resource settings but not previously evaluated in PNG . Aim To evaluate the association between VIA examination findings and high‐risk HPV (hr HPV ) infection; and the impact of concomitant genital Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis on the interpretation of VIA findings. Methods A prospective clinical cohort study among women aged 30–59 years attending Well Woman Clinics in PNG . Main outcome measures were VIA examination findings and laboratory‐confirmed hr HPV , C. trachomatis, N. gonorrhoeae and T. vaginalis . Results A total of 614 women were enrolled, of whom 87.5% (537/614) underwent VIA , and 12.5% (77/614) did not due to pre‐existing cervicitis or inability to visualise the transformation zone. Among the 537 women who underwent VIA , 21.6% were VIA positive, 63.7% VIA negative, and 14.7% had indeterminate findings. The prevalence of hr HPV infection ( n = 614) was 14.7%; C. trachomatis , 7.5%; N. gonorrhoeae , 8.0%; and T. vaginalis , 15.0%. VIA positive women were more likely to have HPV 16 ( odds ratio : 5.0; 95% CI : 1.6–15.6; P = 0.006) but there was no association between HPV 18/45, all hr HPV types (combined), C. trachomatis , N. gonorrhoeae or T. vaginalis . Conclusions VIA positivity was associated with HPV 16, but not with other hr HPV infections, nor with genital C. trachomatis, N. gonorrhoeae or T. vaginalis in this setting.
Materialart:
Online-Ressource
ISSN:
0004-8666
,
1479-828X
DOI:
10.1111/ajo.2018.58.issue-5
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2100324-5
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