In:
Current Protocols in Nucleic Acid Chemistry, Wiley, Vol. 27, No. 1 ( 2006-12)
Abstract:
A simple and efficient method for the preparation of 2‐ O ‐β‐ D ‐ribofuranosylnucleosides, minor tRNA components, is described in this unit. The method consists of condensation of a small excess of 1‐ O ‐acetyl‐2,3,5‐tri‐ O ‐benzoyl‐β‐ D ‐ribofuranose activated with tin tetrachloride with N ‐protected 3,5‐ O ‐tetra‐isopropyldisiloxane‐1,3‐diyl‐ribonucleosides in 1,2‐dichloroethane. Subsequent deprotection produces 2‐ O ‐β‐ D ‐ribofuranosylnucleosides in an overall yield of 46% to 72%.
Type of Medium:
Online Resource
ISSN:
1934-9270
,
1934-9289
DOI:
10.1002/0471142700.2006.27.issue-1
DOI:
10.1002/0471142700.nc0114s27
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2179070-X
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