In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2021-7-6), p. e1009721-
Abstract:
Severe COVID-19 is characterized by extensive pulmonary complications, to which host immune responses are believed to play a role. As the major arm of innate immunity, neutrophils are one of the first cells recruited to the site of infection where their excessive activation can contribute to lung pathology. Low-density granulocytes (LDGs) are circulating neutrophils, whose numbers increase in some autoimmune diseases and cancer, but are poorly characterized in acute viral infections. Using flow cytometry, we detected a significant increase of LDGs in the blood of acute COVID-19 patients, compared to healthy controls. Based on their surface marker expression, COVID-19-related LDGs exhibit four different populations, which display distinctive stages of granulocytic development and most likely reflect emergency myelopoiesis. Moreover, COVID-19 LDGs show a link with an elevated recruitment and activation of neutrophils. Functional assays demonstrated the immunosuppressive capacities of these cells, which might contribute to impaired lymphocyte responses during acute disease. Taken together, our data confirms a significant granulocyte activation during COVID-19 and suggests that granulocytes of lower density play a role in disease progression.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009721
DOI:
10.1371/journal.ppat.1009721.g001
DOI:
10.1371/journal.ppat.1009721.g002
DOI:
10.1371/journal.ppat.1009721.g003
DOI:
10.1371/journal.ppat.1009721.g004
DOI:
10.1371/journal.ppat.1009721.g005
DOI:
10.1371/journal.ppat.1009721.g006
DOI:
10.1371/journal.ppat.1009721.s001
DOI:
10.1371/journal.ppat.1009721.s002
DOI:
10.1371/journal.ppat.1009721.s003
DOI:
10.1371/journal.ppat.1009721.s004
DOI:
10.1371/journal.ppat.1009721.s005
DOI:
10.1371/journal.ppat.1009721.s006
DOI:
10.1371/journal.ppat.1009721.s007
DOI:
10.1371/journal.ppat.1009721.s008
DOI:
10.1371/journal.ppat.1009721.r001
DOI:
10.1371/journal.ppat.1009721.r002
DOI:
10.1371/journal.ppat.1009721.r003
DOI:
10.1371/journal.ppat.1009721.r004
DOI:
10.1371/journal.ppat.1009721.r005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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