In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-30), p. e0266336-
Abstract:
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3 + CD4 + T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266336
DOI:
10.1371/journal.pone.0266336.g001
DOI:
10.1371/journal.pone.0266336.g002
DOI:
10.1371/journal.pone.0266336.t001
DOI:
10.1371/journal.pone.0266336.s001
DOI:
10.1371/journal.pone.0266336.s002
DOI:
10.1371/journal.pone.0266336.s003
DOI:
10.1371/journal.pone.0266336.s004
DOI:
10.1371/journal.pone.0266336.s005
DOI:
10.1371/journal.pone.0266336.s006
DOI:
10.1371/journal.pone.0266336.s007
DOI:
10.1371/journal.pone.0266336.s008
DOI:
10.1371/journal.pone.0266336.s009
DOI:
10.1371/journal.pone.0266336.r001
DOI:
10.1371/journal.pone.0266336.r002
DOI:
10.1371/journal.pone.0266336.r003
DOI:
10.1371/journal.pone.0266336.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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