In:
Photodermatology, Photoimmunology & Photomedicine, Wiley, Vol. 23, No. 2-3 ( 2007-04), p. 95-97
Abstract:
Background: Sezary syndrome and mycosis fungoides are forms of cutaneous T‐cell lymphoma, and in the early stage of these diseases psoralen plus ultraviolet A (PUVA) is one of the treatments of choice. Photodynamic therapy using 5‐aminolevulinic acid (ALA‐PDT) is an effective, non‐invasive, and safe treatment for most superficial skin cancers. In order to obtain greater efficacy of PUVA, we investigated the synergistic anti‐tumor effects of ALA‐PDT and PUVA using 8‐methoxypsoralen (8‐MOP) and a UVA lamp. Methods: The in vitro effects of PUVA and ALA‐PDT and their combination in HUT‐78 cell line from human SS were determined by MTT assay. Results: In our results, cell proliferation compared with controls was inhibited to 53.2% with UVA alone, 52.3% with 1 μM 8‐MOP, 43.8% with 100 μM ALA, and 19.2% with combined 8‐MOP and ALA. Conclusion: Combined use of ALA and PUVA using 8‐MOP and UVA lamps, which are widespread in Japan, had a strong anti‐tumor effect in vitro . Combined treatment with ALA‐PDT and PUVA using a UVA lamp appears to have a strong treatment effect.
Type of Medium:
Online Resource
ISSN:
0905-4383
,
1600-0781
DOI:
10.1111/ppp.2007.23.issue-2-3
DOI:
10.1111/j.1600-0781.2007.00280.x
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2026222-X
detail.hit.zdb_id:
1028855-7
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