In:
Journal of Endovascular Therapy, SAGE Publications, Vol. 5, No. 4 ( 1998-11), p. 349-358
Abstract:
To report an experimental study investigating the ability of nonporous polytetrafluoroethylene (PTFE) covering on a metallic stent to retard the development of neointimal hyperplasia (NIH). Methods: Three groups of Hanford miniature swine underwent standardized balloon injury to both external iliac arteries. Group I animals (control) received balloon injuries only. Group II had the site of balloon injury supported by a properly sized, balloon-expandable Palmaz stent placed directly over the injury site. Group III animals received a Palmaz stent covered with PTFE graft. All animals underwent arteriography immediately after intervention and again prior to sacrifice and specimen harvest at 4 weeks. The specimens were examined grossly and histologically at the proximal, middle, and distal segments for NIH development. Results: Uncovered stents developed significantly more NIH (p 〈 0.0001) and greater luminal narrowing (p 〈 0.001) than the controls. PTFE-covered stents (group III) exhibited less NIH (p 〈 0.001) and luminal reduction (p 〈 0.01) than bare stents (group II) at the middle portion of the stent-graft, but the PTFE cover had no effect on NIH and lumen reduction at the proximal or distal ends of the prosthesis. Conclusions: PTFE-covered stents retarded NIH at 4 weeks, but only at the midportion of the devices; the covering did not prevent neointimal pannus ingrowth at the proximal and distal ends.
Type of Medium:
Online Resource
ISSN:
1526-6028
,
1545-1550
DOI:
10.1177/152660289800500411
Language:
English
Publisher:
SAGE Publications
Publication Date:
1998
detail.hit.zdb_id:
2049858-5
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