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  • 1
    In: Diagnostic and Prognostic Research, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2020-12)
    Abstract: The goal is to investigate prognostic factors for change in memory test performance in healthy older adults and to report and discuss the different statistical procedures used for investigating this topic in the literature. Methods Prognostic factors were here understood as any measures that were investigated to estimate change in memory test performance. MEDLINE, Web of Science Core Collection, CENTRAL, and PsycInfo were searched up to November 2019. Prognostic factor and prognostic factor finding studies investigating prognostic factors on verbal and non-verbal short- and long-term memory after conducting memory training in healthy older adults were included. Risk of bias was assessed using the QUIPS tool. Results Our search yielded 12,974 results. We included 29 studies that address prognostic factors of change in memory test performance, including sociodemographic, (neuro-)psychological, genetic, and biological parameters. Studies showed high variation and methodological shortcomings with regard to the assessment, statistical evaluation, and reporting of the investigated prognostic factors. Included studies used different types of dependent variables (change scores vs. post-test scores) when defining change in memory test performance leading to contradictory results. Age was the only variable investigated throughout most of the studies, showing that older adults benefit more from training when using the change score as the dependent variable. Conclusion Overall, there is a need for adequate reporting in studies of prognostic factors for change in memory test performance. Because of inconsistencies and methodological shortcomings in the literature, conclusions regarding prognostic factors remain uncertain. As a tentative conclusion, one may say that the higher the age of the participant, the more profound the improvement in memory test performance will be after memory training. Trial registration CRD42019127479 .
    Type of Medium: Online Resource
    ISSN: 2397-7523
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2886634-4
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  • 2
    In: International Journal of Geriatric Psychiatry, Wiley, Vol. 38, No. 6 ( 2023-06)
    Abstract: Although cognitive training (CT) is known to have positive effects on quality of life (QoL) and depression, a systematic review examining prognostic factors and models for these effects was lacking. Prognostic factors included were sociodemographics, cognitive reserve, cognitive baseline level, and cognitive change. Data were too heterogenous to draw clear conclusions or conduct meta‐analyses. Future research should enlighten which factors and models predict CT changes on QoL and depression to foster individualized cognitive interventions.
    Type of Medium: Online Resource
    ISSN: 0885-6230 , 1099-1166
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1500455-7
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  • 3
    In: Neurological Sciences, Springer Science and Business Media LLC, Vol. 43, No. 5 ( 2022-05), p. 3153-3163
    Abstract: Subjective cognitive decline (SCD) may occur very early in the course of Parkinson’s disease (PD) before the onset of objective cognitive decline. Data on neural correlates and determinants of SCD in PD are rare. Objective The aim of the present study was to identify neural correlates as well as sociodemographic, clinical, and neuropsychological predictors of SCD in patients with PD. Methods We retrospectively analyzed 30 patients with PD without cognitive impairment (23% female, 66.90 ± 7.20 years, UPDRS-III: 19.83 ± 9.29), of which n  = 12 patients were classified as having no SCD (control group, PD-CG) and n  = 18 as having SCD (PD-SCD). Neuropsychological testing and 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were conducted. SCD was assessed using a questionnaire covering multiple cognitive domains. Results SCD subscores differed significantly between PD-CG and PD-SCD and correlated significantly with other scales measuring related concepts. FDG-PET whole-brain voxel-wise regression analysis revealed hypometabolism in middle frontal, middle temporal, and occipital areas, and the angular gyrus as neural correlates of SCD in PD. Next to this hypometabolism, depressive symptoms were an independent significant determinant of SCD in a stepwise regression analysis (adjusted R 2 = 50.3%). Conclusion This study strengthens the hypothesis of SCD being an early manifestation of future cognitive decline in PD and, more generally, early pathological changes in PD. The early identification of the vulnerability for future cognitive decline constitutes the basis for successful prevention and delay of this non-motor symptom.
    Type of Medium: Online Resource
    ISSN: 1590-1874 , 1590-3478
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1481772-X
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Cognitive Enhancement Vol. 5, No. 3 ( 2021-09), p. 372-385
    In: Journal of Cognitive Enhancement, Springer Science and Business Media LLC, Vol. 5, No. 3 ( 2021-09), p. 372-385
    Abstract: Identifying individuals’ profiles of prognostic factors that predict improvements after nonpharmacological interventions such as memory trainings may help to not only predict individuals’ future outcomes after such intervention, but also tailor new trainings for individuals with specific characteristics. However, until now, no systematic review on prognostic models, defined as a set of multiple prognostic factors to predict a future outcome, for changes in memory performance after memory training exist. MEDLINE, Web of Science Core Collection, CENTRAL, and PsycInfo were searched up to November 2019 to identify studies investigating prognostic models on verbal and non-verbal short- and long-term memory after conducting memory training in healthy older adults. The PROBAST tool was used to assess risk of bias. After screening n  = 10,703 studies, n  = 12 studies were included. These studies and the investigated statistical models are highly heterogeneous, so that conclusions are limited. However, one consistent result was that lower age combined with higher education seems to predict higher improvements after memory training. More studies on prognostic models for memory changes after memory training have to be conducted before clear conclusions which will help to tailor memory trainings to individuals’ profiles can be drawn. Registration: CRD42018105803, https://www.crd.york.ac.uk/PROSPERO
    Type of Medium: Online Resource
    ISSN: 2509-3290 , 2509-3304
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2860286-9
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  • 5
    In: Cochrane Database of Systematic Reviews, Wiley
    Type of Medium: Online Resource
    ISSN: 1465-1858
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2038950-4
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  • 6
    In: European Journal of Applied Physiology, Springer Science and Business Media LLC, Vol. 123, No. 5 ( 2023-05), p. 1015-1026
    Abstract: To examine the acute effects of concurrent muscle power and sport-specific endurance exercises order on immunological stress responses, muscular-fitness, and rating-of-perceived-exertion (RPE) in highly trained youth male judo athletes. Methods Twenty male participants randomly performed two concurrent training (CT) sessions; power-endurance and endurance-power. Measures of immune response (e.g., white blood cells), muscular-fitness (i.e., counter-movement-jump [CMJ]), RPE, blood-lactate, and -glucose were taken at different time-point (i.e., pre, mid, post, and post6h). Results There were significant time*order interactions for white blood cells, lymphocytes, granulocytes, granulocyte-lymphocyte-ratio, and systemic-inflammation-index. Power-endurance resulted in significantly larger pre-to-post increases in white blood cells and lymphocytes while endurance-power resulted in significantly larger pre-to-post increases in the granulocyte-lymphocyte-ratio and systemic-inflammation-index. Likewise, significantly larger pre-to-post6h white blood cells and granulocytes increases were observed following power-endurance compared to endurance-power. Moreover, there was a significant time*order interaction for blood-glucose and -lactate. Following endurance-power, blood-lactate and -glucose increased from pre-to-mid but not from pre-to-post. Meanwhile, in power-endurance blood-lactate and -glucose increased from pre-to-post but not from pre-to-mid. A significant time*order interaction was observed for CMJ-force with larger pre-to-post decreases in endurance-power compared to power-endurance. Further, CMJ-power showed larger pre-to-mid performance decreases following power-endurance, compared to endurance-power. Regarding RPE, significant time*order interactions were noted with larger pre-to-mid values following endurance-power and larger pre-to-post values following power-endurance. Conclusion CT induced acute and delayed order-dependent immune cell count alterations in highly trained youth male judo athletes. In general, power-endurance induced higher acute and delayed immunological stress responses compared to endurance-power. CMJ-force and RPE fluctuated during both CT sessions but went back to baseline 6 h post-exercise.
    Type of Medium: Online Resource
    ISSN: 1439-6319 , 1439-6327
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1459054-2
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Human Neuroscience Vol. 15 ( 2021-4-27)
    In: Frontiers in Human Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-4-27)
    Abstract: Background: Cognitive Training (CT) may contribute to the maintenance and even enhancement of cognitive functions in healthy older adults. However, the question who benefits most from multi-domain CTs is still highly under-investigated. Objective: The goal is to investigate prognostic factors and models for changes in cognitive test performance in healthy older adults after a multi-domain CT. Methods: The data bases MEDLINE, Web of Science Core Collection, CENTRAL, and PsycInfo were searched up to July 2019. Studies investigating prognostic factors and/or models on cognitive outcomes (global cognition, memory, attention, executive functions, language, visuo-spatial abilities) after conducting a multi-domain CT in healthy older adults were included. Risk of Bias was assessed using the QUIPS and the PROBAST tool. Results: 23 prognostic factor and model studies were included. Results indicate a high heterogeneity regarding the conducted multi-domain CTs, the investigated prognostic factors, the investigated outcomes, and the used statistical approaches. Age and neuropsychological performance at study entry were the most investigated predictors, yet they show inconsistent results. Conclusion: Data on prognostic factors and models of changes after multi-domain CT are still too rare and inconsistent to draw clear conclusions due to statistical shortcomings and low reporting quality. Approaches for future research are outlined. Registration: https://www.crd.york.ac.uk/prospero/ , ID: CRD42020147531
    Type of Medium: Online Resource
    ISSN: 1662-5161
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2425477-0
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