In:
Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 2 ( 2023-02), p. 159-165
Abstract:
The impact and outcomes of postnatal cytomegalovirus (CMV) infection are not entirely clear. We aimed to determine the associations between treatment outcomes of postnatal CMV infection and its antiviral treatment. Methods: Retrospective study in a tertiary center. Infants of 〈 29 weeks gestational age who were tested for postnatal CMV infection were included. CMV-infected infants were compared to uninfected infants (control group). CMV-infected infants were either treated with ganciclovir and/or valganciclovir (CMV PT group) or not (CMV PNT group). Demographic, clinical, laboratory, treatment, and outcome data were collected. Primary outcomes were the length of stay, death before discharge and hearing impairment, cognitive and motor development as assessed by the Denver Developmental Screening Test II, and neurologic impairment at the corrected age of 1.5–2 years. Results: We included 103 extremely premature infants. The Median (interquartile range [IQR]) length of stay was 94 (69–112) days in control, 85 (70–102) days in CMV PNT , and 100 (88–137) days in the CMV PT group. Mortality before discharge was 6% in control, 3.8% in CMV PNT , and 3.7% in the CMV PT group. Normal hearing at follow-up was found in 30/37 infants in control (81.1%), 13/13 infants in CMV PNT (100%), and 17/20 infants in the CMV PT group (85%). Denver Developmental Screening Test II results did not differ among the three groups. Neurologic impairment was found in 21/37 infants (56.8%) in control, 9/13 infants in CMV PNT (69.2%), and 14/20 infants in CMV PT group (70%). Conclusions: The associations between antiviral treatment of postnatal CMV infection and better treatment outcomes were nonsignificant.
Type of Medium:
Online Resource
ISSN:
0891-3668
DOI:
10.1097/INF.0000000000003737
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
2020216-7
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