In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-13), p. e0254843-
Abstract:
In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3 rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0254843
DOI:
10.1371/journal.pone.0254843.g001
DOI:
10.1371/journal.pone.0254843.g002
DOI:
10.1371/journal.pone.0254843.g003
DOI:
10.1371/journal.pone.0254843.g004
DOI:
10.1371/journal.pone.0254843.g005
DOI:
10.1371/journal.pone.0254843.g006
DOI:
10.1371/journal.pone.0254843.g007
DOI:
10.1371/journal.pone.0254843.g008
DOI:
10.1371/journal.pone.0254843.t001
DOI:
10.1371/journal.pone.0254843.t002
DOI:
10.1371/journal.pone.0254843.s001
DOI:
10.1371/journal.pone.0254843.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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