GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    The systemic renin-angiotensin system in COVID-19
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-11-22)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-11-22)
    Abstract: SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound enzyme of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective angiotensin 1–7. Using mass spectrometry, we assessed key metabolites of the classical RAS (angiotensins I–II) and alt-RAS (angiotensins 1–7 and 1–5) pathways as well as ACE and ACE2 concentrations in 159 patients hospitalized with COVID-19, stratified by disease severity (severe, n = 76; non-severe: n = 83). Plasma renin activity (PRA-S) was calculated as the sum of RAS metabolites. We estimated ACE activity using the angiotensin II:I ratio (ACE-S) and estimated systemic alt-RAS activation using the ratio of alt-RAS axis metabolites to PRA-S (ALT-S). We applied mixed linear models to assess how PRA-S and ACE/ACE2 concentrations affected ALT-S, ACE-S, and angiotensins II and 1-7. Median angiotensin I and II levels were higher with severe versus non-severe COVID-19 (angiotensin I: 86 versus 30 pmol/L, p   〈  0.01; angiotensin II: 114 versus 58 pmol/L, p   〈  0.05), demonstrating activation of classical RAS. The difference disappeared with analysis limited to patients not taking a RAS inhibitor (angiotensin I: 40 versus 31 pmol/L, p  = 0.251; angiotensin II: 76 versus 99 pmol/L, p  = 0.833). ALT-S in severe COVID-19 increased with time (days 1–6: 0.12; days 11–16: 0.22) and correlated with ACE2 concentration (r = 0.831). ACE-S was lower in severe versus non-severe COVID-19 (1.6 versus 2.6; p   〈  0.001), but ACE concentrations were similar between groups and correlated weakly with ACE-S (r = 0.232). ACE2 and ACE-S trajectories in severe COVID-19, however, did not differ between survivors and non-survivors. Overall RAS alteration in severe COVID-19 resembled severity of disease-matched patients with influenza. In mixed linear models, renin activity most strongly predicted angiotensin II and 1-7 levels. ACE2 also predicted angiotensin 1-7 levels and ALT-S. No single factor or the combined model, however, could fully explain ACE-S. ACE2 and ACE-S trajectories in severe COVID-19 did not differ between survivors and non-survivors. In conclusion, angiotensin II was elevated in severe COVID-19 but was markedly influenced by RAS inhibitors and driven by overall RAS activation. ACE-S was significantly lower with severe COVID-19 and did not correlate with ACE concentrations. A shift to the alt-RAS axis because of increased ACE2 could partially explain the relative reduction in angiotensin II levels.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-24628-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Roadmap on structured waves
    IOP Publishing ; 2023
    In:  Journal of Optics Vol. 25, No. 10 ( 2023-10-01), p. 103001-
    Details
    In: Journal of Optics, IOP Publishing, Vol. 25, No. 10 ( 2023-10-01), p. 103001-
    Abstract: Structured waves are ubiquitous for all areas of wave physics, both classical and quantum, where the wavefields are inhomogeneous and cannot be approximated by a single plane wave. Even the interference of two plane waves, or of a single inhomogeneous (evanescent) wave, provides a number of nontrivial phenomena and additional functionalities as compared to a single plane wave. Complex wavefields with inhomogeneities in the amplitude, phase, and polarization, including topological structures and singularities, underpin modern nanooptics and photonics, yet they are equally important, e.g. for quantum matter waves, acoustics, water waves, etc. Structured waves are crucial in optical and electron microscopy, wave propagation and scattering, imaging, communications, quantum optics, topological and non-Hermitian wave systems, quantum condensed-matter systems, optomechanics, plasmonics and metamaterials, optical and acoustic manipulation, and so forth. This Roadmap is written collectively by prominent researchers and aims to survey the role of structured waves in various areas of wave physics. Providing background, current research, and anticipating future developments, it will be of interest to a wide cross-disciplinary audience.
    Type of Medium: Online Resource
    ISSN: 2040-8978 , 2040-8986
    URL: Article
    DOI: 10.1088/2040-8986/acea92
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2532144-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Recent advances in the self-referencing embedded strings (SELFIES) library
    Royal Society of Chemistry (RSC) ; 2023
    In:  Digital Discovery Vol. 2, No. 4 ( 2023), p. 897-908
    Details
    In: Digital Discovery, Royal Society of Chemistry (RSC), Vol. 2, No. 4 ( 2023), p. 897-908
    Abstract: String-based molecular representations play a crucial role in cheminformatics applications, and with the growing success of deep learning in chemistry, have been readily adopted into machine learning pipelines. However, traditional string-based representations such as SMILES are often prone to syntactic and semantic errors when produced by generative models. To address these problems, a novel representation, SELF-referencing embedded strings (SELFIES), was proposed that is inherently 100% robust, alongside an accompanying open-source implementation called selfies. Since then, we have generalized SELFIES to support a wider range of molecules and semantic constraints, and streamlined its underlying grammar. We have implemented this updated representation in subsequent versions of selfies, where we have also made major advances with respect to design, efficiency, and supported features. Hence, we present the current status of selfies (version 2.1.1) in this manuscript. Our library, selfies, is available at GitHub (https://github.com/aspuru-guzik-group/selfies).
    Type of Medium: Online Resource
    ISSN: 2635-098X
    URL: Article
    DOI: 10.1039/D3DD00044C
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 3142965-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The Government as Institutional Entrepreneur in Corporate Governance Reform
    European Open Science Publishing ; 2022
    In:  European Journal of Business and Management Research Vol. 7, No. 5 ( 2022-10-13), p. 169-174
    Details
    In: European Journal of Business and Management Research, European Open Science Publishing, Vol. 7, No. 5 ( 2022-10-13), p. 169-174
    Abstract: Governments around the world have become prolific issuers of soft law regulation in the form of corporate governance codes. However, the strategies that governments pursue to ensure the diffusion of the codes have remained unexplored in the literature. Drawing from institutional and sociopolitical perspectives, I hypothesize that governments pursue a combination of different intervention strategies to bring the corporate governance arrangements of firms in line with the issued code. These strategies focus on the mobilization of material resources, the dissemination of rationales and legitimating accounts for corporate governance change, interventions in social structure and the establishment of new social relations. I test my hypotheses in the context of the issuance of the national corporate governance code in Germany and find general support for my hypotheses.
    Type of Medium: Online Resource
    ISSN: 2507-1076
    URL: Article
    DOI: 10.24018/ejbmr.2022.7.5.1657
    Language: Unknown
    Publisher: European Open Science Publishing
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    The sounds of science—a symphony for many instruments and voices
    IOP Publishing ; 2020
    In:  Physica Scripta Vol. 95, No. 6 ( 2020-06-01), p. 062501-
    Details
    In: Physica Scripta, IOP Publishing, Vol. 95, No. 6 ( 2020-06-01), p. 062501-
    Type of Medium: Online Resource
    ISSN: 0031-8949 , 1402-4896
    URL: Article
    DOI: 10.1088/1402-4896/ab7a35
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 1477351-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Competing institutional pressures in corporate governance reform: the role of board interlocks and industry peers
    Emerald ; 2017
    In:  Corporate Governance: The International Journal of Business in Society Vol. 17, No. 3 ( 2017-06-05), p. 538-559
    Details
    In: Corporate Governance: The International Journal of Business in Society, Emerald, Vol. 17, No. 3 ( 2017-06-05), p. 538-559
    Abstract: This study aims to examine the effects of competing influences emanating from firms’ social structural context (i.e. sent and received board of director interlocks and industry peers) on the adoption of an institutionally contested corporate governance code provision. Design/methodology/approach The corporate governance code provision of interest in this research recommends that German firms listed on German stock exchanges should disclose the individual remuneration arrangements for their board members. This paper uses 945 firm year observations from 2002 to 2006, the time period during which the adoption of this provision was voluntary for firms, to examine the role of firms’ social structural context in the legitimization process of this provision. Findings The results show that sent board interlocks to firms that defy pressures to adopt this practice have an equally pronounced but opposing effect on its institutionalization process. Received interlocks are inconsequential in this process. The results also provide evidence for the existence of competing influences emanating from firms’ industry peers. In contrast to the effects associated with sent board interlocks, at the industry level, peer acquiescence has a more pronounced effect than peer defiance. Furthermore, the practice’s legitimacy among firms’ peers moderates the effects of sent board interlocks. Originality/value The results of this paper suggest that a balanced approach to studying institutional change in corporate governance needs to acknowledge the co-existence of conflicting signals regarding the spread of new institutional models. The findings suggest that firms’ social structural context plays a central role in processes of contested institutional change. Board interlocks and industry peers carry the potential to facilitate institutional change and facilitate institutional continuity and resistance to change. However, not all board interlocks are of equal importance, and industry peers constitute a source of legitimacy to which directors forming the interlocks attend.
    Type of Medium: Online Resource
    ISSN: 1472-0701
    URL: Article
    DOI: 10.1108/CG-04-2016-0096
    Language: English
    Publisher: Emerald
    Publication Date: 2017
    detail.hit.zdb_id: 2108826-3
    SSG: 3,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Convergence and divergence in corporate governance : An integrative institutional theory perspective
    Emerald ; 2016
    In:  Management Research Review Vol. 39, No. 11 ( 2016-11-21), p. 1447-1471
    Details
    In: Management Research Review, Emerald, Vol. 39, No. 11 ( 2016-11-21), p. 1447-1471
    Abstract: Whether corporate governance systems and practices are converging to the Anglo-American shareholder-value-oriented model or continue to diverge from this model and maintain their idiosyncrasies has been controversially debated among scholars in a variety of academic disciplines. The purpose of this paper is to review, critique and integrate the disparate positions in the convergence-divergence debate in corporate governance and to suggest promising directions for future research. Design/methodology/approach The author constructs a theoretical framework in which convergence and divergence dynamics are conceptualized as simultaneous processes of institutional change and continuity. This framework takes into account the influence of economic market forces, social embeddedness and cultural forces in shaping corporate governance at the national and the firm levels and provides a holistic and integrative perspective on the extant literature in the convergence-divergence debate. Findings The literature review does not support either the predictions of convergence advocates or the predictions of divergence advocates. Instead, the paper finds that convergence and divergence dynamics can coexist and lead to increasing heterogeneity in corporate governance arrangements of firms within and between corporate governance systems. This finding adds complexity to the debate and opens room for interesting research directions. Originality/value The paper offers a comprehensive review of the topic and draws from literature in financial economics, comparative law, economic sociology, international business, political science and strategic management. Most importantly, the paper offers a multi-theoretical framework that allows for an integration of the divergent perspectives presented in the literature.
    Type of Medium: Online Resource
    ISSN: 2040-8269
    URL: Article
    DOI: 10.1108/MRR-05-2014-0103
    Language: English
    Publisher: Emerald
    Publication Date: 2016
    detail.hit.zdb_id: 2538372-3
    SSG: 3,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Conceptual Understanding through Efficient Automated Design of Quantum Optical Experiments
    American Physical Society (APS) ; 2021
    In:  Physical Review X Vol. 11, No. 3 ( 2021-8-26)
    Details
    In: Physical Review X, American Physical Society (APS), Vol. 11, No. 3 ( 2021-8-26)
    Type of Medium: Online Resource
    ISSN: 2160-3308
    URL: Article
    DOI: 10.1103/PhysRevX.11.031044
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2021
    detail.hit.zdb_id: 2622565-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Computer-inspired quantum experiments
    Springer Science and Business Media LLC ; 2020
    In:  Nature Reviews Physics Vol. 2, No. 11 ( 2020-09-29), p. 649-661
    Details
    In: Nature Reviews Physics, Springer Science and Business Media LLC, Vol. 2, No. 11 ( 2020-09-29), p. 649-661
    Type of Medium: Online Resource
    ISSN: 2522-5820
    URL: Article
    DOI: 10.1038/s42254-020-0230-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2947490-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    On scientific understanding with artificial intelligence
    Springer Science and Business Media LLC ; 2022
    In:  Nature Reviews Physics Vol. 4, No. 12 ( 2022-10-11), p. 761-769
    Details
    In: Nature Reviews Physics, Springer Science and Business Media LLC, Vol. 4, No. 12 ( 2022-10-11), p. 761-769
    Type of Medium: Online Resource
    ISSN: 2522-5820
    URL: Article
    DOI: 10.1038/s42254-022-00518-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2947490-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...