In:
BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
Abstract:
Purpose . Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the ⁎ 49A 〉 G (rs7195830) polymorphism is associated with CAD. Materials and Methods . CYBA gene ⁎ 49A 〉 G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results . The frequency of the ⁎ 49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P = 0.020 ), as well as the frequency of the ⁎ 49G allele (62.2% versus 54.0%, P = 0.009 ). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08–1.83 for ⁎ 49G versus ⁎ 49A). Carrier state of the ⁎ 49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50–13.20, P = 0.002 ), as well as the ⁎ 49G allele (OR = 2.25, 95% CI: 1.34–3.77, P = 0.001 ). The ⁎ 49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease ( P = 0.015 ). Conclusion . The CYBA gene ⁎ 49A 〉 G polymorphism modifies the risk of coronary artery disease.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2016/1539671
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2698540-8
Permalink