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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2011
    In:  Journal of Molecular Evolution Vol. 72, No. 1 ( 2011-1), p. 56-71
    In: Journal of Molecular Evolution, Springer Science and Business Media LLC, Vol. 72, No. 1 ( 2011-1), p. 56-71
    Type of Medium: Online Resource
    ISSN: 0022-2844 , 1432-1432
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 1464309-1
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2020
    In:  Animal Frontiers Vol. 10, No. 2 ( 2020-04-01), p. 23-28
    In: Animal Frontiers, Oxford University Press (OUP), Vol. 10, No. 2 ( 2020-04-01), p. 23-28
    Type of Medium: Online Resource
    ISSN: 2160-6056 , 2160-6064
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2628125-9
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  • 3
    In: Physiological Genomics, American Physiological Society, Vol. 47, No. 4 ( 2015-04), p. 129-137
    Abstract: Essentially all high-yielding dairy cows experience a negative energy balance during early lactation leading to increased lipomobilization, which is a normal physiological response. However, a severe energy deficit may lead to high levels of ketone bodies and, subsequently, to subclinical or clinical ketosis. It has previously been reported that the ratio of glycerophosphocholine to phosphocholine in milk is a prognostic biomarker for the risk of ketosis in dairy cattle. It was hypothesized that this ratio reflects the ability to break down blood phosphatidylcholine as a fatty acid resource. In the current study, 248 animals from a previous study were genotyped with Illumina BovineSNP50 BeadChip, and genome-wide association studies were carried out for the milk levels of phosphocholine, glycerophosphocholine, and the ratio of both metabolites. It was demonstrated that the latter two traits are heritable with h 2 = 0.43 and h 2 = 0.34, respectively. A major quantitative trait locus was identified on cattle chromosome 25. The APOBR gene, coding for the apolipoprotein B receptor, is located within this region and was analyzed as a candidate gene. The analysis revealed highly significant associations of polymorphisms within the gene with glycerophosphocholine as well as the metabolite ratio. These findings support the hypothesis that differences in the ability to take up blood phosphatidylcholine from low-density lipoproteins play an important role in early lactation metabolic stability of dairy cows and indicate APOBR to contain a causative variant.
    Type of Medium: Online Resource
    ISSN: 1094-8341 , 1531-2267
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2015
    detail.hit.zdb_id: 2031330-5
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 12 ( 2021-7-15)
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-7-15)
    Abstract: Maternal lineages are important for the breeding decision in the Holstein horse breed. To investigate the genetic diversity of the maternal lineages and the relationships between founder mares, the maternal inherited mitochondrial genome (except the repetitive part of the non-coding region) of 271 mares representing 75 lineages was sequenced. The sequencing predominantly revealed complete homology in the nucleotide sequences between mares from one lineage with exceptions in 13 lineages, where differences in one to three positions are probably caused by de novo mutations or alternate fixation of heteroplasmy. We found 78 distinct haplotypes that have not yet been described in other breeds. Six of these occurred in two or three different lineages indicating a common ancestry. Haplotypes can be divided into eight clusters with all mares from one lineage belonging to the same cluster. Within a cluster, the average number of pairwise differences ranged from zero to 16.49 suggesting close maternal relationships between these mares. The results showed that the current breeding population originated from at least eight ancestral founder mares.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 5
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2020
    In:  Journal of Animal Science Vol. 98, No. Supplement_4 ( 2020-11-30), p. 30-31
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 98, No. Supplement_4 ( 2020-11-30), p. 30-31
    Abstract: Worldwide, dairy cattle breeding companies and farmers face several challenges, including concerns about climatic impact of milk production, increasing scarcity of natural resources and feed, and concerns about animal welfare and health. The recording of accurate and comprehensive phenotypic data for these new issues is important for both management and breeding. Technological developments play a key role in this context. An increasing spectrum of traits with relevance to the breeding goal has become available (e.g. behavioral traits from sensor-derived activity patterns, milk metabolites reflecting the metabolic status, direct or indirect measurements of methane emissions). The biological background and genetic architecture of many of the evolving novel traits as well as their relationship with other traits of interest is not yet well understood, which hinders appropriate implementation in breeding programs. Especially for traits that are difficult or expensive to measure, such as feed intake or methane emissions, phenotypes are scarce. Interdisciplinary research and across-country data pooling can be enormously helpful to ensure a fast progress. Hence, the development of universal guidelines for recording is a crucial step, also with regard to a successful application of genomic selection, which enables the improvement of difficult-to-measure traits by transferring genomic knowledge from estimates within comparatively small reference populations to the population level. Furthermore, some traits (e.g. feed intake) show a lactation-stage specific genetic architecture. This highlights the importance of repeated measurements as well as knowledge on genetic correlations among all relevant traits across days in milk, the latter being an important prerequisite for designing balanced breeding strategies. With more traits, especially more complex traits, increasing data sources and volumes, setting up reasonable breeding goals becomes much more sophisticated and often requires innovative approaches.
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1490550-4
    SSG: 12
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  • 6
    In: Archives Animal Breeding, Copernicus GmbH, Vol. 63, No. 2 ( 2020-07-02), p. 211-218
    Abstract: Abstract. Archaeol is a cell membrane lipid of methanogenic archaea excreted in feces and is therefore a potential biomarker for individual methane emission (MEM). The aims of this study were to examine the potential of the fecal archaeol concentration (fArch) to be a proxy for MEM prediction in cows fed different diets and determine if the time of fecal collection affected the archaeol concentration. Thus, we investigated (i) the variation of the fArch concentration in spot samples of feces taken thrice within 8 h during respiration chamber measurements and (ii) the effect of two diets differing in nutrient composition and net energy content on the relationship between fArch and MEM in lactating cows. Two consecutive respiration trials with four primiparous and six multiparous lactating Holstein cows were performed. In the first trial (T1) at 100±3 d in milk (IM), a diet moderate in starch and fat content was fed for ad libitum intake, whereas in the second trial (T2) at 135±3 d IM, cows received a diet lower in starch and fat. Individual MEM (g d−1) was measured for 24 h. Fecal samples were taken at 06:30, 10:00, and 14:30 LT and analyzed for fArch using Soxhlet lipid extraction and GC–MS. Cows produced less methane (364 g CH4 d−1) during T1 and had significantly lower fArch concentrations (37.1 µg g−1 dry matter; DM) compared to T2 (392 g CH4 d−1 and 47.6 µg g−1 DM). A significant positive relationship between fArch (µg g−1 fecal DM) and MEM, expressed on a dry matter intake (DMI) basis (g kg−1 DMI), was found (R2=0.53, n=20). Among samples collected over the day, those collected at 10:00 LT provided the best coefficient of determination for MEM (R2=0.23). In conclusion, fArch offers some potential in serving as a proxy for innovative breeding schemes to lower enteric methane when fecal samples are taken at a certain time of the day, but more data on the sources of variation of the MEM : fArch ratios are required.
    Type of Medium: Online Resource
    ISSN: 2363-9822
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 2235451-7
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  • 7
    In: Journal of Animal Breeding and Genetics, Wiley, Vol. 135, No. 4 ( 2018-08), p. 275-285
    Abstract: Reliable estimates of genetic parameters for growth traits as a trajectory of age are needed to optimize existing turbot breeding programmes. To evaluate the potential of early selection strategies, the use of biometric body measurements, length (L), width (W) and area (A), at early ages as alternative indicators for the selection trait at harvest was explored. Random regression model (RRM) based on molecular relatedness (MR) was used to analyse the trajectory of genetic parameters for growth traits in turbot from 162 to 756 days posthatch (dph). Heritability estimates for body weight (BW) ranged from 0.34 to 0.54. Heritability estimates for W, A and L were also moderate to high ranging from 0.18 to 0.43. Estimates for L and W declined with age, while those for A increased towards harvest age. Genetic ( r G ) and phenotypic ( r P ) correlations between BW and the three morphometric traits L, A and W were estimated using simple bivariate animal models at young (AC1), medium (AC2) and old (AC3) age classes. Correlations between BW and morphometric body traits were high, ranging from 0.7 to 0.9 in all three age groups. Genetic correlations between traits were highest ( 〉 0.9) in AC3. To explore the potential for early selection, genetic correlations were derived from the RRM between all days of measurement for all traits separately. From dph 300 onwards, intratrait estimates of r G were moderate to high (above 0.7 for dph 410 and higher ages for traits BW, L and A). Results showed that genetic selection for BW, L and A is promising and that A and L could be successfully used as alternative indicator traits if measurements of BW are not available. Large BW and A at harvest could be achieved as a correlated response to early selection for these traits at around 500 dph.
    Type of Medium: Online Resource
    ISSN: 0931-2668 , 1439-0388
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020402-4
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  • 8
    In: Animals, MDPI AG, Vol. 12, No. 6 ( 2022-03-11), p. 704-
    Abstract: Maternal lineages are considered an important factor in breeding. Mitochondrial DNA (mtDNA) is maternally inherited and plays an important role in energy metabolism. It has already been associated with energy consumption and performances, e.g., stamina in humans and racehorses. For now, corresponding studies are lacking for sport performance of warmblood breeds. MtDNA sequences were available for 271 Holstein mares from 75 maternal lineages. As all mares within a lineage showed identical haplotypes regarding the non-synonymous variants, we expanded our data set by also including non-sequenced mares and assigning them to the lineage-specific haplotype. This sample consisting of 6334 to 16,447 mares was used to perform mitochondrial association analyses using breeding values (EBVs) estimated on behalf of the Fédération Équestre Nationale (FN) and on behalf of the Holstein Breeding Association (HOL). The association analyses revealed 20 mitochondrial SNPs (mtSNPs) significantly associated with FN-EBVs and partly overlapping 20 mtSNPs associated with HOL-EBVs. The results indicated that mtDNA contributes to performance differences between maternal lineages. Certain mitochondrial haplogroups were associated with special talents for dressage or show jumping. The findings encourage to set up innovative genetic evaluation models that also consider information on maternal lineages.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 9
    In: Journal of Applied Genetics, Springer Science and Business Media LLC, Vol. 63, No. 4 ( 2022-12), p. 783-792
    Abstract: In horses, parentage control is currently performed based on an internationally standardized panel of 17 microsatellite (MS) markers comprising 12 mandatory and five optional markers. Unlike MS, single nucleotide polymorphism (SNP) profiles support a wider portfolio of genomic applications, including parentage control. A transition to SNP-based parentage control is favorable, but requires additional efforts for ensuring generation-overlapping availability of marker genotypes of the same type. To avoid double genotyping of either parents or offspring for changing to SNP technology and enable efficient transition, we tested whether MS genotypes used for parentage control could be reliably imputed from a medium-density SNP panel in German warmblood horses. Imputation accuracy was tested in a tenfold cross-validation with two approaches: within breed (option A) and across breeds (option B). Average imputation accuracies of 97.98% (A) and 96.17% (B) were achieved, respectively. Due to interbreed differences in genotyping rates, five MS markers of low genotyping rate (GTR;  〈  90%) could be imputed with higher accuracy within breed (98.18%) than across breeds (90.73%). MS markers with high GTR performed homogeneously well in option B (98.44%) and showed slightly lower accuracy in option A (97.90%). Among these markers, AHT5 proved to be problematic for imputation regardless of the approach, revealing accuracies of 86.40% (A) and 88.70% (B). Better results for MS markers with high GTR and savings in computational processing justified the choice of option B for routine implementation. To date, more than 9500 horses have undergone the new parentage control based on imputed MS genotypes.
    Type of Medium: Online Resource
    ISSN: 1234-1983 , 2190-3883
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2194407-6
    SSG: 12
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  • 10
    In: Journal of Applied Genetics, Springer Science and Business Media LLC, Vol. 63, No. 2 ( 2022-05), p. 369-378
    Abstract: Reliability of genomic predictions is influenced by the size and genetic composition of the reference population. For German Warmblood horses, compilation of a reference population has been enabled through the cooperation of five German breeding associations. In this study, preliminary data from this joint reference population were used to genetically and genomically characterize withers height and to apply single-step methodology for estimating genomic breeding values for withers height. Using data on 2113 mares and their genomic information considering about 62,000 single nucleotide polymorphisms (SNPs), analysis of the genomic relationship revealed substructures reflecting breed origin and different breeding goals of the contributing breeding associations. A genome-wide association study confirmed a known quantitative trait locus (QTL) for withers height on equine chromosome (ECA) 3 close to LCORL and identified a further significant peak on ECA 1. Using a single-step approach with a combined relationship matrix, the estimated heritability for withers height was 0.31 (SE = 0.08) and the corresponding genomic breeding values ranged from − 2.94 to 2.96 cm. A mean reliability of 0.38 was realized for these breeding values. The analyses of withers height showed that compiling a reference population across breeds is a suitable strategy for German Warmblood horses. The single-step method is an appealing approach for practical genomic prediction in horses, because not many genotypes are available yet and animals without genotypes can by this way directly contribute to the estimation system.
    Type of Medium: Online Resource
    ISSN: 1234-1983 , 2190-3883
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2194407-6
    SSG: 12
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