Abstract: This study deals with stability and quality of surface treatment of concrete roof tiles, considering the use of special inorganic binders spraying onto freshly prefabricated surface of concrete roof tiles. Their application leads to smoothing of surface defects generated from previous processing. Method of applying the coating is discussed in this work among with stability study of styrene-acrylate cement mixtures. Impact of presence of selected styrene-acrylate copolymer onto the hydration of cement is evaluated, in order to verify, for how long could be prepared mixture used for treating freshly fabricated surface of concrete roof tiles. Pull-off tests results after freeze-thaw test are further presented in this study to verify designed coating process properties.

Abstract: This paper describes the aspectual classes in Abui, a Papuan language of the Timor-Alor-Pantar family. Abui innovated a system of aspectual stem pairing, realized by consonant mutation, vowel grading, and rime mutation. Although stem pairing is widespread (about 61% of the verbs alternate), about 38% of our 1,330 verb sample are unpaired and immutable. Abui verbal stems combine with aspectual affixes, adverbs and auxiliary verbs, whose distribution is used here together with the stem types to describe aspectual classes, which are understood as lexicalizations of transitional possibilities of lexical items (e.g. inchoative-stative vs. inchoative-gradual.inchoative-stative). The paper takes the bidimensional approach to aspect distinguishing between properties associated with the perfective-imperfective system and other aspectual marking (cf. Sasse, Hans-Jürgen. 2002. Recent activity in the theory of aspect: accomplishments, achievements, or just non-progressive state? Linguistic Typology 6(2). 199–271). Combining the features of both types of aspectual marking, we construct in a bottom-up fashion the aspectual classes in Abui and also show that these may be further refined if contextual features such as valency or degree of change (affectedness) were included. A characteristic feature of the Abui system is the elaborate system of stative-inchoative verbs sensitive to scalar and change properties (e.g. instant vs. gradual). Abui telic verbs show sensitivity to the properties of the resulting state and are formally associated with stem alternation.

Abstract: The structure of the unstable solvate of the semisynthetic ergot derivate terguride methanol solvate C 20 H 28 N 4 O .CH 3 OH, was solved by direct methods and refined to an R value of 0.093 for 1 462 unique observed reflections. The title alkaloid crystallizes in the orthorhombic space group P2 1 2 1 2 1 with lattice parameters a = 10.438(1), b = 13.200(4), c = 15.495(5) Å, V = 2 134.8(9) Å 3 , Z = 4. An indole moiety of the terguride molecule is almost perfect planar, ring C has an E 6 envelope conformation and ring D adopts a 1 C 4 chair shape. As found from X-ray powder diffraction study, terguride methanol solvate completely transforms to terguride monohydrate in air during several hours.

Abstract: The primary objective of this study is to test the hypothesis that administration of dexamethasone 20 mg is superior to a 6 mg dose in adult patients with moderate or severe ARDS due to confirmed COVID-19. The secondary objective is to investigate the efficacy and safety of dexamethasone 20 mg versus dexamethasone 6 mg. The exploratory objective of this study is to assess long-term consequences on mortality and quality of life at 180 and 360 days. Trial design REMED is a prospective, phase II, open-label, randomised controlled trial testing superiority of dexamethasone 20 mg vs 6 mg. The trial aims to be pragmatic, i.e. designed to evaluate the effectiveness of the intervention in conditions that are close to real-life routine clinical practice. Participants The study is multi-centre and will be conducted in the intensive care units (ICUs) of ten university hospitals in the Czech Republic. Inclusion criteria Subjects will be eligible for the trial if they meet all of the following criteria: 1. Adult (≥18 years of age) at time of enrolment; 2. Present COVID-19 (infection confirmed by RT-PCR or antigen testing); 3. Intubation/mechanical ventilation or ongoing high-flow nasal cannula (HFNC) oxygen therapy; 4. Moderate or severe ARDS according to Berlin criteria:  • Moderate – PaO 2 /FiO 2 100–200 mmHg;  • Severe – PaO 2 /FiO 2 〈 100 mmHg; 5. Admission to ICU in the last 24 hours. Exclusion criteria Subjects will not be eligible for the trial if they meet any of the following criteria: 1. Known allergy/hypersensitivity to dexamethasone or excipients of the investigational medicinal product (e.g. parabens, benzyl alcohol); 2. Fulfilled criteria for ARDS for ≥14 days at enrolment; 3. Pregnancy or breastfeeding; 4. Unwillingness to comply with contraception measurements from enrolment until at least 1 week after the last dose of dexamethasone (sexual abstinence is considered an adequate contraception method); 5. End-of-life decision or patient is expected to die within next 24 hours; 6. Decision not to intubate or ceilings of care in place; 7. Immunosuppression and/or immunosuppressive drugs in medical history:  a) Systemic immunosuppressive drugs or chemotherapy in the past 30 days;  b) Systemic corticosteroid use before hospitalization;  c) Any dose of dexamethasone during the present hospital stay for COVID-19 for ≥5 days before enrolment;  d) Systemic corticosteroids during present hospital stay for conditions other than COVID-19 (e.g. septic shock); 8. Current haematological or generalized solid malignancy; 9. Any contraindication for corticosteroid administration, e.g.  • intractable hyperglycaemia;  • active gastrointestinal bleeding;  • adrenal gland disorders;  • presence of superinfection diagnosed with locally established clinical and laboratory criteria without adequate antimicrobial treatment; 10. Cardiac arrest before ICU admission; 11. Participation in another interventional trial in the last 30 days. Intervention and comparator Dexamethasone solution for injection/infusion is the investigational medicinal product as well as the comparator. The trial will assess two doses, 20 mg (investigational) vs 6 mg (comparator). Patients in the intervention group will receive dexamethasone 20 mg intravenously once daily on day 1–5, followed by dexamethasone 10 mg intravenously once daily on day 6–10. Patients in the control group will receive dexamethasone 6 mg day 1–10. All authorized medicinal products containing dexamethasone in the form of solution for i.v. injection/infusion can be used. Main outcomes Primary endpoint: Number of ventilator-free days (VFDs) at 28 days after randomisation, defined as being alive and free from mechanical ventilation. Secondary endpoints a) Mortality from any cause at 60 days after randomisation; b) Dynamics of inflammatory marker (C-Reactive Protein, CRP) change from Day 1 to Day 14; c) WHO Clinical Progression Scale at Day 14; d) Adverse events related to corticosteroids (new infections, new thrombotic complications) until Day 28 or hospital discharge; e) Independence at 90 days after randomisation assessed by Barthel Index. The long-term outcomes of this study are to assess long-term consequences on mortality and quality of life at 180 and 360 days through telephone structured interviews using the Barthel Index. Randomisation Randomisation will be carried out within the electronic case report form (eCRF) by the stratified permuted block randomisation method. Allocation sequences will be prepared by a statistician independent of the study team. Allocation to the treatment arm of an individual patient will not be available to the investigators before completion of the whole randomisation process. The following stratification factors will be applied: • Age 〈 65 and ≥ 65; • Charlson Comorbidity index (CCI) 〈 3 and ≥3; • CRP 〈 150 mg/L and ≥150 mg/L • Trial centre. Patients will be randomised in a 1 : 1 ratio into one of the two treatment arms. Randomisation through the eCRF will be available 24 hours every day. Blinding (masking) This is an open-label trial in which the participants and the study staff will be aware of the allocated intervention. Blinded pre-planned statistical analysis will be performed. Numbers to be randomised (sample size) The sample size is calculated to detect the difference of 3 VFDs at 28 days (primary efficacy endpoint) between the two treatment arms with a two-sided type I error of 0.05 and power of 80%. Based on data from a multi-centre randomised controlled trial in COVID-19 ARDS patients in Brazil and a multi-centre observational study from French and Belgian ICUs regarding moderate to severe ARDS related to COVID-19, investigators assumed a standard deviation of VFD at 28 days as 9. Using these assumptions, a total of 142 patients per treatment arm would be needed. After adjustment for a drop-out rate, 150 per treatment arm (300 patients per study) will be enrolled. Trial Status This is protocol version 1.1, 15.01.2021. The trial is due to start on 2 February 2021 and recruitment is expected to be completed by December 2021. Trial registration The study protocol was registered on EudraCT No.:2020-005887-70, and on December 11, 2020 on ClinicalTrials.gov (Title: Effect of Two Different Doses of Dexamethasone in Patients With ARDS and COVID-19 (REMED)) Identifier: NCT04663555 with a last update posted on February 1, 2021. Full protocol The full protocol (version 1.1) is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the standard formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.

Abstract: The diene-transmissive Diels–Alder (DTDA) reactions of dendralenes are emerging as a powerful synthetic tool. To date, these processes have been studied with non-polarized or mildly polarized species. We now present an expedient synthesis of strongly electron-deficient [3]dendralenes and demonstrate, for the first time, their DTDA reactions with electron-poor dienophiles. While the combination of two electron-poor partners is believed to be generally disfavored, DTDA reactions reported herein proceed at 100 °C with high yields and stereoselectivities. DFT calculations show that this electronically disfavored process is encouraged by a steric effect of the vinylic moiety within the dendralene core, driving the diene segment into the s- cis conformation, thereby lowering the activation energy by 2–3 kcal mol −1 . While the free energy barrier is typically lower for the second cycloaddition, the two barriers become similar for dendralenes with a cyclic enone fragment, which allows a controlled stepwise addition of two different dienophiles.