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  • 1
    Online Resource
    Online Resource
    Immunological Memory of Psoriatic Lesions
    MDPI AG ; 2020
    In:  International Journal of Molecular Sciences Vol. 21, No. 2 ( 2020-01-17), p. 625-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 2 ( 2020-01-17), p. 625-
    Abstract: The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms21020625
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 2
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    Dystrophic calcifications in case of a patient with systemic lupus erythematosus – case report and literature review
    Collegium Medicum, University of Warmia and Mazury ; 2021
    In:  Polish Annals of Medicine
    Details
    In: Polish Annals of Medicine, Collegium Medicum, University of Warmia and Mazury
    Abstract: Introduction: Cutis calcification is the deposition of calcium in the skin and subcutaneous tissues and is classified into four subsets. Dystrophic calcifications are the most common type of skin calcification, occurring mainly in damaged tissues or in course of autoimmune disease. However, the coexistance of systemic lupus erythematosus (SLE) and soft tissue calcification is described rarely. Aim: This article presents a case of dystrophic calcifications in the buttocks area in a 49-year-old woman with a 17-year history of SLE. Case study: We report a case of 49-year-old women with SLE who developed nodular lesions in the buttock area. The radiological and histopatological examinations of the nodules showed presence of calcifications. The calcium metabolism parameters were in a normal range. The diagnosis of dystrophic calcinosis in the course of SLE was established. Results and discussion: Dystrophic calcifications associated with autoimmune diseases are common, but occur rarely in SLE. It should be noted that patients with SLE can also develop calcifications of different types like metastatic or iatrogenic. Dystrophic calcifications in SLE usually present as small nodules on buttocks or limbs. The pathophysiology remains unclear, however, there are some theories that inflammation and vascular ischemia play a role in its process. Conclusions: Calcifications in case of patients with SLE rarely require treatment. Several pharmacologic and surgical therapies have been tested with variable results. Additional research to establish an accepted treatment algorithm should be conducted.
    Type of Medium: Online Resource
    ISSN: 1230-8013
    URL: Article
    DOI: 10.29089/20
    DOI: 10.29089/2020.20.00170
    Language: English
    Publisher: Collegium Medicum, University of Warmia and Mazury
    Publication Date: 2021
    detail.hit.zdb_id: 2572030-2
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  • 3
    Online Resource
    Online Resource
    Distal interphalangeal joint extensor tendon enthesopathy in patients with nail psoriasis
    Springer Science and Business Media LLC ; 2019
    In:  Scientific Reports Vol. 9, No. 1 ( 2019-03-06)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-03-06)
    Abstract: The aim of the study was an ultrasound assessment of distal interphalangeal (DIP) joint enthesopathy in patients with nail psoriasis. Altogether, 72 patients with nail psoriasis (41 with psoriasis and 31 with psoriatic arthritis) and 30 people in the control group participated in the study. In total, 1014 nails were examined. The thickness of DIP digital extensor tendons in the groups of patients with psoriasis (Ps) and psoriatic arthritis (PsA) was correlated with the nail bed thickness (r = 0.316, p = 0.027 vs. r = 0.402, p = 0.031, respectively) and with the thickness of the nail matrix in patients with psoriasis (r = 0.421, p = 0.012). The linear regression model showed the tendon thickness in Ps patients to be affected by the nail bed thickness, duration of psoriasis and the thickness of the nail matrix, whereas in PsA patients it was found to be significantly affected by duration of psoriasis and of arthritis, the nail bed thickness, CRP concentration and the swollen joint count. Our findings may indicate the role of the nail-tendon apparatus changes in the PsA development and they emphasise the justifiability of US examinations in patients with psoriasis direct assessment of morphological changes in nails as potential predictors of PsA development.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-019-39985-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2615211-3
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  • 4
    Online Resource
    Online Resource
    Does the lifestyle of patients with psoriasis affect their illness?
    Walter de Gruyter GmbH ; 2021
    In:  Postępy Higieny i Medycyny Doświadczalnej Vol. 75, No. 1 ( 2021-11-29), p. 643-654
    Details
    In: Postępy Higieny i Medycyny Doświadczalnej, Walter de Gruyter GmbH, Vol. 75, No. 1 ( 2021-11-29), p. 643-654
    Abstract: Psoriasis is one of the most common chronic, incurable inflammatory skin diseases, affecting 2–4% of the general population. Etiopathogenesis of this disease remains unclear. It is widely considered to be a multifactorial disorder caused by the interaction between inherited susceptibility alleles and environmental risk factors, such as lifestyle, diet, stimulants, foci of inflammation, and psychological factors. The widespread prevalence of psoriasis is a very significant health and socioeconomic problem. Treatment of psoriasis is based on relieving the acute symptoms of the disease. Despite the implementation of many therapeutic options, including biological treatment, effectiveness of these options is not always sufficient, or in some patients it is not satisfactory. In order to properly control the symptoms of the disease, the patient should be told that the therapeutic effect is achieved not only by pharmacotherapy but also by introducing appropriate healthy habits in everyday life. This article discusses the importance of patient-controlled factors that affect the severity of psoriasis. Theimportance of regular exercise, smoking avoidance, and reduced alcohol consumption is explained, as well as the importance for psoriasis treatment of psychotherapy and spa therapy. Understanding the essence of these factors in the treatment of psoriasis is important in achieving satisfactory therapeutic effects.
    Type of Medium: Online Resource
    ISSN: 1732-2693
    URL: Article
    DOI: 10.2478/ahem-2021-0033
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2150116-6
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  • 5
    Online Resource
    Online Resource
    Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomized, double-blind study in rheumatoid arthritis
    Oxford University Press (OUP) ; 2022
    In:  Rheumatology Vol. 61, No. 4 ( 2022-04-11), p. 1385-1395
    Details
    In: Rheumatology, Oxford University Press (OUP), Vol. 61, No. 4 ( 2022-04-11), p. 1385-1395
    Abstract: To compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active RA. Methods This double-blind, phase III study randomized (1:1) subjects with active RA to receive 40 mg (100 mg/ml) CT-P17 or European Union-sourced reference adalimumab subcutaneously every 2 weeks (Q2W) until week (W) 24 [treatment period (TP) 1]. Thereafter, subjects receiving reference adalimumab were randomized (1:1) to continue reference adalimumab or switch to CT-P17 from W26 (both Q2W until W48; TP2). Subjects receiving CT-P17 in TP1 continued CT-P17. W0–W24 results were previously reported; we present W26–W52 findings. End points were efficacy (including joint damage progression), pharmacokinetics, safety and immunogenicity. Results Of 607 subjects who initiated TP2 treatment, 303 continued CT-P17, 153 continued reference adalimumab and 151 switched to CT-P17. Efficacy improvements up to W24 were maintained during TP2; efficacy was comparable among groups. At W52, 20% improvement in ACR response rates were 80.5% (continued CT-P17), 77.8% (continued reference adalimumab) and 82.2% (switched to CT-P17). Joint damage progression was minimal. Mean trough serum adalimumab concentrations were similar among groups. CT-P17 and reference adalimumab safety profiles were numerically similar and switching did not affect immunogenicity. At W52, 28.4% (continued CT-P17), 27.0% (continued reference adalimumab) and 28.3% (switched to CT-P17) of subjects were anti-drug antibody-positive. Conclusion Efficacy, pharmacokinetics, safety and immunogenicity of CT-P17 and reference adalimumab were comparable after 1 year of treatment, including after switching from reference adalimumab to CT-P17. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov, NCT03789292.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    URL: Article
    DOI: 10.1093/rheumatology/keab460
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1474143-X
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  • 6
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    Changes in body composition and bone mineral density n postmenopausal women with psoriatic arthritis
    Termedia Sp. z.o.o. ; 2017
    In:  Rheumatology Vol. 55, No. 5 ( 2017-10-31), p. 215-221
    Details
    In: Rheumatology, Termedia Sp. z.o.o., Vol. 55, No. 5 ( 2017-10-31), p. 215-221
    Abstract: 〈 b 〉 Objective 〈 /b 〉 : Prolonged inflammation status due to psoriatic arthritis (PsA) may contribute to the loss of muscle mass, extending from muscle weakness, and increased risk of falls and fractures. The risk of fractures and their complications increases with concomitant osteoporosis. 〈 br / 〉 〈 b 〉 Material and methods 〈 /b 〉 : The study included 95 women aged 50–75 years. The presence of sarcopenia was evaluated in a group of 51 women with PsA, and 44 controls (without inflammatory joint disease). Measurements of muscle mass and lean body mass were made using the method of bioimpedance assessing ALM (Appendicular Lean Mass) index and SMI (Skeletal Muscle Index). The diagnosis of sarcopenia was made in women with low muscle mass and concomitant reduction of the efficiency of the assessed functional test Timed Up and Go (TUG). Bone density measurement was done by densitometry in the femoral neck and lumbar spine. (Ethics statement OIL 625/16/Bioet). 〈 br / 〉 〈 b 〉 Results 〈 /b 〉 : Sarcopenia, using ALM index and SMI, was diagnosed in 13.7% and 43.1% of PsA women, and in healthy women in 9% and 20.4%, respectively. In the group of PsA, sarcopenia was associated with a significant increase in the occurrence of disorders of bone mineralisation (72.7% vs. 41.3% in patients without a decrease in muscle mass). There was no correlation between the loss of muscle mass, bone density, and activity of PsA. 〈 br / 〉 〈 b 〉 Conclusions 〈 /b 〉 : The prevalence of sarcopenia in postmenopausal women suffering from PsA is associated with the occurrence of osteoporosis.
    Type of Medium: Online Resource
    ISSN: 0034-6233 , 2084-9834
    Uniform Title: Changes in body composition and bone mineral density in postmenopausal women with psoriatic arthritis
    URL: Article
    DOI: 10.5114/reum.2017.71627
    Language: Polish
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2017
    detail.hit.zdb_id: 2233668-0
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  • 7
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    Online Resource
    Sleep disorders in patients with psoriatic arthritis and psoriasis
    Termedia Sp. z.o.o. ; 2018
    In:  Rheumatology Vol. 56, No. 5 ( 2018-10-31), p. 301-306
    Details
    In: Rheumatology, Termedia Sp. z.o.o., Vol. 56, No. 5 ( 2018-10-31), p. 301-306
    Abstract: To assess and measure occurrence of sleep disorders in patients with psoriatic arthritis (PsA) and psoriasis (Ps). Material and methods The study included 62 patients with psoriatic arthritis and 52 patients with psoriasis. The measurement of sleep quality was conducted using the Pittsburgh Sleep Quality Index (PSQI), the evaluation of fatigue by the fatigue subscale of the FACIT-F questionnaire and the patient’s quality of life by the Health Assessment Questionnaire (HAQ). The psoriasis severity was determined using the Psoriasis Area Severity Index (PASI) and the activity of arthritis by the disease activity score of 28 joints (DAS 28). The Visual Analogue Scale (VAS) was used to assess the severity of pain. Results Poor sleep quality was found in 67.7% of PsA patients, 57.7% in Ps patients and 14.6% within the control group. Sleeping disorders in patients with PsA and Ps were related to worse quality of life and intense fatigue. Methotrexate treatment was not related to sleeping disorders, but an improvement in sleep quality was observed in both PsA and Ps patients who were treated with anti TNF- antibodies (p 〈 0.001 and p = 0.032 respectively). Following the use of the linear regression model, the following factors worsen the sleep quality in PsA: pain (R2 = 0.462, p 〈 0.001), tender joint count (R2 = 0.434, p 〈 0.001), C-reactive protein (CRP) concentration (R2 = 0.391, p 〈 0.001), patient’s age (R2 = 0.284, p = 0.003) and duration of psoriasis (R2 = 0.166, p = 0.006). In Ps patients the factors were: severity of skin lesions (R2 = 0.329, p 〈 0.001), duration of psoriasis (R2 = 0.290, p = 0.004) and patient’s age (R2 = 0.282, p = 0.019). Conclusions Poor sleep quality in patients with PsA or Ps is a common symptom. Sleep disorders are more frequent in patients with PsA than in those with psoriasis.
    Type of Medium: Online Resource
    ISSN: 0034-6233 , 2084-9834
    Uniform Title: Zaburzenia snu u chorych na łuszczycowe zapalenie stawów i łuszczycę
    URL: Article
    DOI: 10.5114/reum.2018.79501
    Language: Polish
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2018
    detail.hit.zdb_id: 2233668-0
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  • 8
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    Online Resource
    Ocular lesions in Behçet’s disease
    VM Media Group sp. z o.o ; 2022
    In:  Rheumatology Forum Vol. 7, No. 4 ( 2022-03-29), p. 165-168
    Details
    In: Rheumatology Forum, VM Media Group sp. z o.o, Vol. 7, No. 4 ( 2022-03-29), p. 165-168
    Type of Medium: Online Resource
    ISSN: 2720-3913 , 2720-3921
    URL: Article
    DOI: 10.5603/FR.2021.0021
    Language: Unknown
    Publisher: VM Media Group sp. z o.o
    Publication Date: 2022
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  • 9
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    Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient
    MDPI AG ; 2022
    In:  Medicina Vol. 58, No. 10 ( 2022-09-27), p. 1354-
    Details
    In: Medicina, MDPI AG, Vol. 58, No. 10 ( 2022-09-27), p. 1354-
    Abstract: Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaustive search, ineffectiveness of antibiotics, and high sensitivity to corticosteroid therapy. AAS is characterized by the development of deep, inflammatory abscesses and systemic symptoms (weight loss, abdominal pain, fever, and leukocytosis). They may be associated with inflammatory bowel disease (IBD) and autoimmune diseases. The patient in this study is a 67-year-old man, suffering from rheumatoid arthritis (RA), with numerous purulent abscesses in the mediastinum, within the subcutaneous tissue above the extension surfaces of the joints, and on the dorsum of the hands. The lesions are accompanied by bone destruction. The patient was treated with prednisone 40 mg and adalimumab, which resulted in a quick reduction of inflammatory markers and clinical improvement, as well as the healing and absorption of abscesses. Despite COVID-19 infection, treatment with remdesivir, prednisone, and adalimumab was continued, with the complete resolution of the lesions. AAS is difficult to recognize, so practitioners have to be aware of this condition, especially in patients with RA.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina58101354
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2088820-X
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  • 10
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    Higher Risk of Future Cardiovascular Events Among Patients with Psoriatic Arthritis Compared to Psoriatic Patients Between the Ages of 30-50
    Bentham Science Publishers Ltd. ; 2018
    In:  The Open Dermatology Journal Vol. 12, No. 1 ( 2018-02-19), p. 5-11
    Details
    In: The Open Dermatology Journal, Bentham Science Publishers Ltd., Vol. 12, No. 1 ( 2018-02-19), p. 5-11
    Abstract: Psoriasis and Psoriatic Arthritis (PsA) are chronic diseases with a number of complications that, among others, may include alterations in the cardio-vascular system. Methods: The aim of this study was to evaluate the risk of Cardiovascular Diseases (CVD) in patients with psoriasis and psoriatic arthritis between the ages of 30-50. The research covered 95 outpatients and inpatients: 51 with plaque psoriasis (23 women and 28 men) and 44 with psoriasis and psoriatic arthritis (16 women and 28 men). The risk of cardio-vascular incident was evaluated with the use of the Framingham algorithm covering the age, total cholesterol, HDL cholesterol, blood pressure, the habit of smoking and diabetes. The 10-year risk of the occurrence of a cardio-vascular incident was higher in patients with psoriatic arthritis than in patients with plaque psoriasis (9,9% vs 6,2%). A high risk of cardio-vascular events was observed in 35% men with psoriatic arthritis in comparison to 11% men with only psoriasis. In patients with plaque psoriasis, the increase in the risk of cardio-vascular incident was connected with the late beginning of psoriasis; whereas in the group of patients with psoriatic arthritis, the risk of cardio-vascular incident was connected with the intensification of psoriatic lesions. Conclusion: The patients with psoriasis, especially men with psoriatic arthritis, certainly require special medical care in terms of cardio-vascular diseases prevention.
    Type of Medium: Online Resource
    ISSN: 1874-3722
    URL: Article
    DOI: 10.2174/187437220181201005
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2018
    detail.hit.zdb_id: 2396043-7
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