In:
Bioscience, Biotechnology, and Biochemistry, Informa UK Limited, Vol. 85, No. 4 ( 2021-03-24), p. 890-894
Abstract:
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotransformation of the synthetic intermediate before. Their structures were determined by the spectroscopic data and the chemical derivatization. 12-Ketomethymycin showed a weak cytotoxicity against SKOV-3 and Jurkat cells, although its N-oxide analog did not show any activity. Both showed no antibacterial activities against Escherichia coli and Micrococcus luteus.
Type of Medium:
Online Resource
ISSN:
1347-6947
Language:
English
Publisher:
Informa UK Limited
Publication Date:
2021
detail.hit.zdb_id:
2110940-0
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