In:
Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 7, No. 5 ( 1980-10), p. 535-539
Abstract:
1. Disappearance of tritiated noradrenaline from plasma, after infusion to steady‐state, was studied to assess neuronal uptake of noradrenaline in essential hypertension. 2. Plasma tritiated noradrenaline disappearance was biexponential. Rapid removal was dependent on neuronal uptake, being slowed both in normal subjects after desipramine, and in patients with sympathetic nerve dysfunction (autonomic insufficiency). 3. In nine of thirty‐eight hypertensive patients the t1½ similarly was prolonged. Endogenous noradrenaline escaping uptake after release, and spilling over into plasma, was increased in these patients. 4. Defective neuronal uptake of noradrenaline, by exposing adrenergic receptors to high local transmitter concentration, may be important in the pathogenesis of essential hypertension in some patients.
Type of Medium:
Online Resource
ISSN:
0305-1870
,
1440-1681
DOI:
10.1111/cep.1980.7.issue-5
DOI:
10.1111/j.1440-1681.1980.tb00106.x
Language:
English
Publisher:
Wiley
Publication Date:
1980
detail.hit.zdb_id:
189277-0
detail.hit.zdb_id:
2020033-X
SSG:
15,3
Permalink