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  • 1
    Online Resource
    Online Resource
    Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 2 ( 2021-02), p. 030006052098154-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 2 ( 2021-02), p. 030006052098154-
    Abstract: This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO). Methods We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments. Results The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died. Conclusions There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520981549
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Serum Levels of S100A11 and MMP-9 in Patients with Epithelial Ovarian Cancer and Their Clinical Significance
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-3-3), p. 1-5
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-3-3), p. 1-5
    Abstract: Objective. To investigate the serum levels of calgizzarin (S100A11) and matrix metalloproteinase-9 (MMP9) in patients with epithelial ovarian cancer (EOC) and determine their clinical significance. Methods. Serum levels of S100A11 and MMP9 were detected in patients with EOC, patients with benign ovarian tumor, and healthy women. The correlation between the two markers and clinicopathological characteristics of ovarian cancer was analysed. Results. The serum levels of S100A11 and MMP-9 in patients with EOC were higher than those in patients with benign ovarian tumor and in healthy women, and the expression levels of S100A11 and MMP-9 were positively correlated. S100A11 and MMP-9 were correlated with tumor staging, postoperative residual foci, ascites volume, serum CA125 level, chemotherapy response, and lymph node metastasis, while S100A11 and MMP-9 were not associated with the bilevel classification, histological type, age, and degree of differentiation. Conclusion. S100A11 and MMP-9 were both highly expressed in the serum of patients with EOC and were associated with cancer development, invasion, and metastasis. Therefore, they can be used as an important reference maker in the diagnosis and treatment of ovarian cancer.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/7341247
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 3
    Online Resource
    Online Resource
    Exosomal adrenomedullin derived from cancer-associated fibroblasts promotes lipolysis in adipose tissue
    BMJ ; 2018
    In:  Gut Vol. 67, No. 12 ( 2018-12), p. 2226-2227
    Details
    In: Gut, BMJ, Vol. 67, No. 12 ( 2018-12), p. 2226-2227
    Type of Medium: Online Resource
    ISSN: 0017-5749 , 1468-3288
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1136/gutjnl-2017-315778
    DOI: 10.1136/gutjnl-2017-315778.supp1
    DOI: 10.1136/gutjnl-2017-315778.supp2
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 1492637-4
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  • 4
    Online Resource
    Online Resource
    Home energy management optimization method considering potential risk cost
    Elsevier BV ; 2020
    In:  Sustainable Cities and Society Vol. 62 ( 2020-11), p. 102378-
    Details
    In: Sustainable Cities and Society, Elsevier BV, Vol. 62 ( 2020-11), p. 102378-
    Type of Medium: Online Resource
    ISSN: 2210-6707
    URL: Article
    DOI: 10.1016/j.scs.2020.102378
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2573417-9
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  • 5
    Online Resource
    Online Resource
    Chronic Pancreatitis and Pancreatic Cancer
    S. Karger AG ; 2014
    In:  Gastrointestinal Tumors Vol. 1, No. 3 ( 2014), p. 123-134
    Details
    In: Gastrointestinal Tumors, S. Karger AG, Vol. 1, No. 3 ( 2014), p. 123-134
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Pancreatic cancer (PC) is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP) is a common chronic inflammatory disease of unknown etiology that affects the pancreas. Epidemiological studies have identified CP to be a major risk factor for PC. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 A greater understanding of the molecular mechanisms linking CP and PC has identified several common pathways that provide targets for future interventions. This article reviews those components in the CP-PC connection, including the role of macrophages, the maintenance of genome stability, cytokines, and other nodal factors such as nuclear factor kappa B, COX-2 and reactive oxygen species. 〈 b 〉 〈 i 〉 Key Message: 〈 /i 〉 〈 /b 〉 The molecular mechanisms that underlie CP and PC provide novel targets for future therapies for PC. 〈 b 〉 〈 i 〉 Practical Implications: 〈 /i 〉 〈 /b 〉 The stromal-desmoplastic reaction plays an important role in initiating and sustaining chronic inflammation and tumor progression. Recently, two targeted anti-tumor agents, erlotinib and nab-paclitaxel, have shown promising therapeutic efficacy. Notably, both these agents target components (EGFR and SPARC) within the inflammatory stroma surrounding malignant cells, underscoring the importance of inflammation in pancreatic carcinogenesis. Identifying the common pathways linking CP and PC may help uncover additional novel targets for future therapies.
    Type of Medium: Online Resource
    ISSN: 2296-3774 , 2296-3766
    URL: Article
    DOI: 10.1159/000365306
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2735769-7
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  • 6
    Online Resource
    Online Resource
    Comprehensive expression analysis reveals several miRNAs against acute pancreatitis via modulating autophagy
    CMB Association ; 2023
    In:  Cellular and Molecular Biology Vol. 69, No. 3 ( 2023-03-31), p. 129-134
    Details
    In: Cellular and Molecular Biology, CMB Association, Vol. 69, No. 3 ( 2023-03-31), p. 129-134
    Type of Medium: Online Resource
    ISSN: 1165-158X , 0145-5680
    URL: Article
    DOI: 10.14715/cmb/2023.69.3.18
    Language: Unknown
    Publisher: CMB Association
    Publication Date: 2023
    detail.hit.zdb_id: 2161289-4
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 12 ( 2023-1-23)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2023-1-23)
    Abstract: Extracellular vesicles are fundamentally significant in the communication between cells. Outer Membrane Vesicles(OMVs) are a special kind of EVs produced by Gram-negative bacteria, which are minute exosome-like particles budding from the outer membrane, which have been found to play essential roles in diverse bacterial life events, including regulation of microbial interactions, pathogenesis promotion, stress responses and biofilm formation. Recently, and more researches have explored the substantial potentials of EVs as natural functional nanoparticles in the bioengineering applications in infectious diseases, cardiovascular diseases, autoimmune diseases and neurological diseases, such as antibacterial therapy, cancer drugs and immunoadjuvants, with several candidates in clinical trials showing promising efficacy. However, due to the poor understanding of sources, membrane structures and biogenesis mechanisms of EVs, progress in clinical applications still remains timid. In this review, we summarize the latest findings of EVs, especially in gastrointestinal tract tumours, to provide a comprehensive introduction of EVs in tumorigenesis and therapeutics.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.1103446
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 8
    Online Resource
    Online Resource
    Table_1.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-6-13)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-6-13)
    Abstract: Cuproptosis is a newly discovered type of cell death. Little is known about the roles that cuproptosis related genes (CRGs) play in colorectal cancer (CRC). The aim of this study is to evaluate the prognostic value of CRGs and their relationship with tumor immune microenvironment. Methods TCGA-COAD dataset was used as the training cohort. Pearson correlation was employed to identify CRGs and paired tumor-normal samples were used to identify those CRGs with differential expression pattern. A risk score signature was constructed using LASSO regression and multivariate Cox stepwise regression methods. Two GEO datasets were used as validation cohorts for confirming predictive power and clinical significance of this model. Expression patterns of seven CRGs were evaluated in COAD tissues. In vitro experiments were conducted to validate the expression of the CRGs during cuproptosis. Results A total of 771 differentially expressed CRGs were identified in the training cohort. A predictive model termed riskScore was constructed consisting of 7 CRGs and two clinical parameters (age and stage). Survival analysis suggested that patients with higher riskScore showed shorter OS than those with lower ( P & lt; 0.0001). ROC analysis revealed that AUC values of cases in the training cohort for 1-, 2-, and 3-year survival were 0.82, 0.80, 0.86 respectively, indicating its good predictive efficacy. Correlations with clinical features showed that higher riskScore was significantly associated with advanced TNM stages, which were further confirmed in two validation cohorts. Single sample gene set enrichment analysis (ssGSEA) showed that high-risk group presented with an immune-cold phenotype. Consistently, ESTIMATE algorithm analysis showed lower immune scores in riskScore-high group. Expressions of key molecules in riskScore model are strongly associated with TME infiltrating cells and immune checkpoint molecules. Patients with a lower riskScore exhibited a higher complete remission rate in CRCs. Finally, seven CRGs involved in riskScore were significantly altered between cancerous and paracancerous normal tissues. Elesclomol, a potent copper ionophore, significantly altered expressions of seven CRGs in CRCs, indicating their relationship with cuproptosis. Conclusions The cuproptosis-related gene signature could serve as a potential prognostic predictor for colorectal cancer patients and may offer novel insights into clinical cancer therapeutics.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2023.1083956
    DOI: 10.3389/fonc.2023.1083956.s001
    DOI: 10.3389/fonc.2023.1083956.s002
    DOI: 10.3389/fonc.2023.1083956.s003
    DOI: 10.3389/fonc.2023.1083956.s004
    DOI: 10.3389/fonc.2023.1083956.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 9
    Online Resource
    Online Resource
    A novel lncRNA PTTG3P/miR-132/212-3p/FoxM1 feedback loop facilitates tumorigenesis and metastasis of pancreatic cancer
    Springer Science and Business Media LLC ; 2020
    In:  Cell Death Discovery Vol. 6, No. 1 ( 2020-11-30)
    Details
    In: Cell Death Discovery, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-11-30)
    Abstract: Pseudogene pituitary tumor-transforming 3 (PTTG3P) is emerging as a key player in the development and progression of cancer. However, the biological role and clinical significance of PTTG3P in pancreatic ductal adenocarcinoma (PDAC) remain unclear. Here, we found that PTTG3P was significantly upregulated in PDAC tissues. Elevated PTTG3P expression correlated with larger tumor size and worse differentiation, and reduced overall survival. Bioinformatics and experimental evidence revealed that PTTG3P promoted malignant phenotypes and FoxM1 signaling pathway in PDAC cells. Mechanistically, PTTG3P functions as a microRNA sponge to positively regulate the expression of FoxM1 through sponging miR-132/212-3p. Moreover, it showed that FoxM1 transcriptionally activated PTTG3P expression, thus forming a feedback loop to promote the aggressiveness of PDAC cells. Taken together, our findings suggest that PTTG3P promotes PDAC progression through PTTG3P/miR-132/212-3p/FoxM1 feedforward circuitry and it may serve as a promising diagnostic marker or target for treatment in PDAC patients.
    Type of Medium: Online Resource
    ISSN: 2058-7716
    URL: Article
    DOI: 10.1038/s41420-020-00360-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2842546-7
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  • 10
    Online Resource
    Online Resource
    Stepwise robust distribution system state estimation considering PMU measurement
    AIP Publishing ; 2019
    In:  Journal of Renewable and Sustainable Energy Vol. 11, No. 2 ( 2019-03-01)
    Details
    In: Journal of Renewable and Sustainable Energy, AIP Publishing, Vol. 11, No. 2 ( 2019-03-01)
    Abstract: In order to deal with the problem of robustness and computing speed of distribution system state estimation with the development of phasor technology, a stepwise distribution system state estimation with robust performance and considering real-time phasor measurement unit (PMU) measurements is proposed. The proposed method utilizes the absolute value of residuals to construct the weight function and uses the unit weight variance to standardize the residuals so that the residual precision can be unified on the same scale to improve robustness. Besides, the state estimation is divided into two steps. The first step makes use of supervisory control and data acquisition (SCADA) measurements and branch current phasors measured by PMU to perform the robust estimation, and due to the high sparsity of the Jacobian matrix, the computational efficiency can be ensured. The second step combines the estimation results of the first step with the voltage phasors measured by PMU to perform linear state estimation, which can update the result of the first step and realize the combination of SCADA and PMU measurements in the state estimation. Finally, the proposed method is verified by the Institute of Electrical and Electronics Engineers (IEEE) standard systems.
    Type of Medium: Online Resource
    ISSN: 1941-7012
    URL: Article
    DOI: 10.1063/1.5064532
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2019
    detail.hit.zdb_id: 2444311-6
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