In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-4-11)
Abstract:
We evaluated the difference in parathyroid visualization on 18 F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT. Methods This retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent 18 F-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses. Results Dual-time 18 F-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783). Conclusion The quantitative parameters of 60min 18 F-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT.
Type of Medium:
Online Resource
ISSN:
1664-2392
DOI:
10.3389/fendo.2023.1100056
DOI:
10.3389/fendo.2023.1100056.s001
DOI:
10.3389/fendo.2023.1100056.s002
DOI:
10.3389/fendo.2023.1100056.s003
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2592084-4
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