In:
International Journal of Cancer, Wiley, Vol. 133, No. 10 ( 2013-11-15), p. 2284-2295
Abstract:
What's new? Calcium has been involved in diverse cellular processes associated with cancer development. Despite growing evidence for the potential tumor suppressive properties of CACNA2D3 —an auxiliary member of the alpha‐2/delta subunit family of the voltage‐dependent calcium channel complex—the mechanism underlying its role in Nasopharyngeal Carcinoma (NPC) remains unclear. Here the authors demonstrate for the first time that CACNA2D3 ‐mediated increase in intracellular calcium activates NLK via the Wnt/Ca2+ non‐canonical Wnt pathway. The observed epigenetic silencing of CACNA2D3 may also be required for accumulated β‐catenin to effectively activate Wnt‐associated oncogenes known to promote apoptosis evasion, cell proliferation, invasion, metastasis, and epithelial‐to‐mesynchemal transition.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Permalink