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  • 1
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    Online Resource
    Evaluation of the Efficacy and Prognosis of MRI Combined with miR-134 in Neo-adjuvant Chemotherapy Combined with Breast-conserving Surgery
    Auricle Technologies, Pvt., Ltd. ; 2021
    In:  Tobacco Regulatory Science Vol. 7, No. 4 ( 2021-07-31), p. 588-596
    Details
    In: Tobacco Regulatory Science, Auricle Technologies, Pvt., Ltd., Vol. 7, No. 4 ( 2021-07-31), p. 588-596
    Abstract: To explore the application effect of MRI and miR-134 in neo-adjuvant chemotherapy combined with breast-conserving surgery. Sixty-one patients who received neo-adjuvant chemotherapy combined with breast-conserving surgery were collected as observation group (OG), and other 53 patients who received breast-conserving surgery at the same time were collected as control group (CG). The positive surgical margins rate, axillary lymph node metastasis rate, 5-year survival rate, recurrence rate and miR-134 expression before and after treatment were compared between the two groups. The diagnostic ability of MRI and miR-134 before treatment for axillary lymph node metastasis and the prognostic significance of miR-134 after treatment were explored. The positive surgical margins rate in OG was obviously lower than that in CG. There was no significant difference in axillary lymph node metastasis rate. There was no obvious difference in 5-year survival rate in both groups. The 5-year recurrence rate in OG was obviously lower than that in CG. Before therapy, the area under ROC curve (AUC) of miR-134 in diagnosing axillary lymph node metastasis was 0.788, and the specificity and sensitivity were 70.59% and 86.25%. The specificity and sensitivity of MRI diagnosis were 90.00% and 76.47%, and the combined diagnosis was 63.75% and 97.06%, so the sensitivity was improved. After treatment, the AUC of miR-134 in predicting 5-year survival was 0.810, and that of miR-134 in predicting 5-year recurrence was 0.767. To sum up, neo-adjuvant chemotherapy combined with breast-conserving surgery can decline the postoperative recurrence rate of patients. Preoperative miR-134 combined with MRI can diagnose axillary lymph node metastasis, and preoperative miR-134 can predict the prognosis.
    Type of Medium: Online Resource
    ISSN: 2333-9748
    URL: Article
    DOI: 10.18001/TRS.7.4.1.10
    Language: English
    Publisher: Auricle Technologies, Pvt., Ltd.
    Publication Date: 2021
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  • 2
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    LPS-pretreatment adipose-derived mesenchymal stromal cells promote wound healing in diabetic rats by improving angiogenesis
    Elsevier BV ; 2022
    In:  Injury Vol. 53, No. 12 ( 2022-12), p. 3920-3929
    Details
    In: Injury, Elsevier BV, Vol. 53, No. 12 ( 2022-12), p. 3920-3929
    Type of Medium: Online Resource
    ISSN: 0020-1383
    URL: Article
    DOI: 10.1016/j.injury.2022.09.041
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 218778-4
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  • 3
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    Association between Socioeconomic Status, Physical Health and Need for Long-Term Care among the Chinese Elderly
    MDPI AG ; 2019
    In:  International Journal of Environmental Research and Public Health Vol. 16, No. 12 ( 2019-06-15), p. 2124-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 16, No. 12 ( 2019-06-15), p. 2124-
    Abstract: The aim of this study was to explore the relationship between socioeconomic status (SES), physical health and the need for long-term care (NLTC) of the Chinese elderly, and further, to provide evidence-based advice for establishing an LTC system in China. A cross-sectional survey was conducted in Shandong Province, China in 2017 by using multi-stage random sampling method. Data were collected from elderly individuals aged 60 years and older by self-designed questionnaires through face-to face interviews. A total of 7070 participants were finally included in the database (40.3% male, 59.7% female). Chi-square test analysis and structural equation modeling (SEM) were conducted to clarify the association between SES, physical health and NLTC among the Chinese elderly men and women in Shandong Province. The results of the SEM analysis showed that physical health exerted a strong and negative effect on the NLTC for both genders, with a slightly stronger effect found among the elderly men. SES was found to be significantly and negatively related to the NLTC among the elderly women, while no statistical significance was found for the association between SES and NLTC for elderly men. A significant and positive association between SES and physical health was observed among the elderly men and women, with a slightly stronger effect among the elderly women. Implications for lowering the NLTC and developing an LTC system were addressed based on the findings above.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph16122124
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2175195-X
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  • 4
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    [Retracted] Clinical Effect of Clarithromycin Combined with Tinidazole on Helicobacter pylori‐Related Gastritis and Its Influence on COX‐2 Expression
    Wiley ; 2021
    In:  BioMed Research International Vol. 2021, No. 1 ( 2021-01)
    Details
    In: BioMed Research International, Wiley, Vol. 2021, No. 1 ( 2021-01)
    Abstract: Studies have shown that COX‐2 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori‐induced inflammation, suggesting that cyclooxygenase‐2 (COX‐2) may play an important role in gastric carcinogenesis. We attempted to investigate the role of clarithromycin with tinidazole on Helicobacter pylori‐related gastritis from the aspects of clinical effect and COX‐2 expression. From January 2016 to January 2019, 130 patients with Helicobacter pylori‐related chronic gastritis were collected and grouped into the observation group (OG) and the control group (CG). Altogether, 80 patients in the OG were treated with clarithromycin with tinidazole, while 50 patients in the CG were treated with amoxicillin with metronidazole. Clinical symptom improvement time, content of COX‐2 and B cell lymphoma‐2 (BCL‐2), content of inflammatory factors interleukin‐1 (IL‐1), IL‐4, and C‐reactive protein (CRP), expression level of nutritional indicators serum albumin (ALB), realbumin (PA), and transferrin (TF), clearance of Helicobacter pylori, total effective rate, and incidence of adverse reactions were detected. Compared with the CG, the OG had shorter clinical symptom improvement time, lower COX‐2 and Bcl‐2, lower expression of inflammatory factors IL‐1, IL‐4, and CRP, higher expression of nutritional indicators ALB, TF, and PA, higher clearance rate of Helicobacter pylori, higher total effective rate, and lower incidence of adverse reactions. Clarithromycin combined with tinidazole can effectively improve the clinical effect of Helicobacter pylori‐related gastritis and reduce the expression level of COX‐2.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Issue
    URL: Article
    DOI: 10.1155/bmri.v2021.1
    DOI: 10.1155/2021/4171019
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2705584-X
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  • 5
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    US of thyroid nodules: can AI-assisted diagnostic system compete with fine needle aspiration?
    Springer Science and Business Media LLC ; 2023
    In:  European Radiology Vol. 34, No. 2 ( 2023-08-24), p. 1324-1333
    Details
    In: European Radiology, Springer Science and Business Media LLC, Vol. 34, No. 2 ( 2023-08-24), p. 1324-1333
    Type of Medium: Online Resource
    ISSN: 1432-1084
    URL: Article
    DOI: 10.1007/s00330-023-10132-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1472718-3
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  • 6
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    The Relationship between Socioeconomic Status, Mental Health, and Need for Long-Term Services and Supports among the Chinese Elderly in Shandong Province—A Cross-Sectional Study
    MDPI AG ; 2019
    In:  International Journal of Environmental Research and Public Health Vol. 16, No. 4 ( 2019-02-13), p. 526-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 16, No. 4 ( 2019-02-13), p. 526-
    Abstract: This study aims to clarify the association between socioeconomic status (SES), mental health, and the need for long-term services and support (NLTSS) of the Chinese elderly, and further, to provide evidence-based suggestions for the development of the long-term services and support (LTSS) system in China. A cross-sectional survey using a multi-stage random sampling method was conducted in Shandong Province, China, in 2017. Data were collected from seniors aged over 60 years old through questionnaires by face-to face interviews. A total of 7070 subjects were included in the final database (40.3% male and 59.7% female). A chi-square test analysis and structural equation modeling (SEM) were employed to explore the relationship between SES, mental health, and NLTSS for both male and female elderly people. The SEM analysis showed that mental health was significantly and negatively associated with NLTSS for both male elderly and female elderly, and it was slightly stronger among the male elderly. A significant and negative relationship was observed between SES and NLTSS for both genders, and the association was stronger among the female elderly. SES exerted a positive effect on mental health for both male and female elderly people, and a slightly stronger effect was found among the male elderly. Advice for the development of a LTSS system in China was given based on the above results.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph16040526
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2175195-X
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  • 7
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    Abundance and Metabolism Disruptions of Intratumoral Microbiota by Chemical and Physical Actions Unfreeze Tumor Treatment Resistance
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 7 ( 2022-03)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 7 ( 2022-03)
    Abstract: Intratumoral or intestinal microbiota correlates with tumorigenesis and progression, and microbiota regulation for reinforcing various anti‐tumor approaches is of significant importance, which, however, suffers from no precise regulation method and unclear underlying mechanism. Herein, a microbiome metabolism‐engineered phototherapy strategy is established, wherein Nb 2 C/Au nanocomposite and the corresponding phototherapy are harnessed to realize “chemical” and “physical” bacterial regulations. Flora analysis and mass spectrometry (MS) and metabonomics combined tests demonstrate that the synergistic microbiota regulations can alter the abundance, diversity of intratumoral microbiome, and disrupt metabolic pathways of microbiome and tumor microenvironment, wherein the differential singling pathways and biosynthetic necessities or metabolites that can affect tumor progression are identified. As well, anti‐TNF α is introduced to unite with bacterial regulation to synergistically mitigate bacterial‐induced inflammation, which, along with the metabolism disruptions of intratumoral microbiota and tumor microenvironment, unfreezes tumor resistance and harvests significantly‐intensified phototherapy‐based anti‐tumor outcomes against 4T1 and CT26 tumors. The clear underlying principles of microbiome‐regulated tumorigenesis and the established microbiome metabolism regulation method provide distinctive insights into tumor therapy, and can be also extended to other gut microbiome‐associated lesions interference.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.7
    DOI: 10.1002/advs.202105523
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 8
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    Negative life events and self-harm among the elderly: Result from a survey of 7070 people aged≥60 in China
    Elsevier BV ; 2021
    In:  Psychiatry Research Vol. 298 ( 2021-04), p. 113727-
    Details
    In: Psychiatry Research, Elsevier BV, Vol. 298 ( 2021-04), p. 113727-
    Type of Medium: Online Resource
    ISSN: 0165-1781
    URL: Article
    DOI: 10.1016/j.psychres.2021.113727
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 445361-X
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  • 9
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    The effects of oral health and social support on health-related quality of life of migrant older with children in Weifang, China
    Springer Science and Business Media LLC ; 2022
    In:  BMC Public Health Vol. 22, No. 1 ( 2022-08-06)
    Details
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-06)
    Abstract: With the accelerated urbanization and aging population in China, more and more migrant older with children (MOC) moved to new cities. Previous studies mainly explored the acculturation of MOC, yet few focused on the health conditions of this vulnerable group. This study aimed to investigate the effects of oral health and social support on health-related quality of life (HRQOL) of MOC in Weifang, China. Method This study was a cross-sectional study and participants were selected by multi-stage cluster random sampling in Weifang, China. The HRQOL was assessed via the 12-item Short-Form Health Survey (SF-12) which included the mental component summary (MCS) and the physical component summary (PCS). The oral health was evaluated by the Geriatric Oral Health Assessment Index (GOHAI). The social support was administered using the Social Support Rating Scale (SSRS). Descriptive analysis was used to describe participants’ sociodemographic variables, oral health and social support. Univariate analysis and binary logistic regression analysis was used to investigate the association between the social support, oral health and HRQOL. Results and discussion It was found that 25.0% of MOC were defined as MCS poor and PCS poor, respectively. Those participants with average and low monthly household income compared to those around them, average and poor oral health, and low levels of social support were more likely to have poor PCS. Those with temporary residence permits, fair and poor oral health, and medium and low levels of social support were more likely to report poor MCS. Conclusion Results indicated that better social support and oral health led to higher HRQOL of MOC. Implications for the government, communities and families of MOC were given to improve their HRQOL.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    URL: Article
    DOI: 10.1186/s12889-022-13843-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041338-5
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  • 10
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    Socioeconomic Status, Comorbidity, Activity Limitation, and Healthy Life Expectancy in Older Men and Women : A 6-Year Follow-Up Study in Japan
    SAGE Publications ; 2014
    In:  Journal of Applied Gerontology Vol. 33, No. 7 ( 2014-10), p. 831-847
    Details
    In: Journal of Applied Gerontology, SAGE Publications, Vol. 33, No. 7 ( 2014-10), p. 831-847
    Abstract: This study aimed to explore the structural contributions of socioeconomic status (SES), comorbidity, and activity limitation to the healthy life expectancy (HALE) of Japanese suburban elderly. A questionnaire survey was distributed to all residents aged 65 years and older in Tama City, Tokyo, in 2001; a follow-up study was conducted in 2004; and individual vital status data from the municipal residents’ registry were tracked until 2007. In all, 7,905 respondents were included for analysis. Data analysis was performed by structural equation modeling (SEM). The data were well fit by the models, and HALE was found to be well explained by SES, comorbidity, and activity limitation ( R 2 = .59 for men and R 2 = .71 for women). In conclusion, elderly people with higher SES were more likely to live longer with good self-rated health, via living with less chronic diseases and better performance in daily living activities, especially for elderly women.
    Type of Medium: Online Resource
    ISSN: 0733-4648 , 1552-4523
    URL: Article
    DOI: 10.1177/0733464813503041
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2089028-X
    detail.hit.zdb_id: 155897-3
    SSG: 5,2
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