GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    The decidual expression of Interleukin‐7 is upregulated in early pregnancy loss
    Wiley ; 2021
    In:  American Journal of Reproductive Immunology Vol. 86, No. 3 ( 2021-09)
    Details
    In: American Journal of Reproductive Immunology, Wiley, Vol. 86, No. 3 ( 2021-09)
    Abstract: Maternal immunological rejection of the semi‐allogenic fetus is discussed as one of the significant factors involved in early pregnancy loss. An array of cytokines secreted by both maternal and fetal cells is involved in generating a delicate maternal immune tolerance. Interleukin‐7 (IL‐7) is discussed to play a key role in pro‐inflammatory processes, but there is still limited insight into the pathophysiological input on placentation and embryonic development in early pregnancy loss. Patients and methods Cytokine level differences were identified with quantitative real‐time PCR in placental tissue from spontaneous abortions (SA) ( n  = 18), recurrent spontaneous abortions (RSA) ( n  = 15), and healthy pregnancies ( n  = 15) at gestational weeks 7 to 14. Protein expression of IL‐7 in the decidua was investigated by immunohistochemistry. IL‐7‐expressing cells were identified with double‐immunofluorescence. Results Decidua of women with RSA expressed almost 51‐times higher values of IL‐7 in gene expression analysis. Immunohistochemistry identified a significant upregulation of IL‐7 in the decidua of RSA specimens ( p  = .013) and in the decidua of women with SA ( p  = .004). Double‐immunofluorescence confirmed decidual stroma cells as IL‐7‐expressing cells. Conclusion Significantly elevated IL‐7 values in the decidua of spontaneous and recurrent miscarriages imply a crucial role of the cytokine in the signaling at the feto‐maternal interface of the placenta. An overexpression of IL‐7 could result in early pregnancy loss by inducing a pro‐inflammatory environment. Proven to be valuable in other autoimmune diseases, targeting IL‐7 signaling therapeutically may prove to be a very beneficial treatment option for RSA patients.
    Type of Medium: Online Resource
    ISSN: 1046-7408 , 1600-0897
    URL: Issue
    URL: Article
    DOI: 10.1111/aji.v86.3
    DOI: 10.1111/aji.13437
    RVK:
    XA 20240
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2024667-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Expression of H3K4me3 and H3K9ac in breast cancer
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Cancer Research and Clinical Oncology Vol. 146, No. 8 ( 2020-08), p. 2017-2027
    Details
    In: Journal of Cancer Research and Clinical Oncology, Springer Science and Business Media LLC, Vol. 146, No. 8 ( 2020-08), p. 2017-2027
    Abstract: Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival Methods H3K4me3 and H3K9ac expression was immunohistochemically examined in 235 tissue samples. Results Positive estrogen receptor status was correlated with a higher IRS of the nuclear ( p  = 0.033), and of the cytoplasmic H3K4me3 staining ( p  = 0.009). H3K9ac intensity was associated to the Her2 status ( p  = 0.045) and to poor prognosis in cells with positive Ki67 status ( p  = 0.013). A high intensity of nuclear H3K4me3 staining was found to be correlated with a lower 10-year-survival ( p  = 0.026) and with lower breast cancer-specific survival ( p  = 0.004). High percentage score ( 〉  190) of H3K9ac expression was correlated to worse breast cancer-specific survival ( p  = 0.005). Shorter progression-free survival was found in patients with nuclear ( p  = 0.013) and cytoplasmic H3K4me3expression ( p  = 0.024) and H3K9ac expression ( p  = 0.023). Conclusion This analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies.
    Type of Medium: Online Resource
    ISSN: 0171-5216 , 1432-1335
    URL: Article
    DOI: 10.1007/s00432-020-03265-z
    RVK:
    XA 52301
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1459285-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer
    Springer Science and Business Media LLC ; 2020
    In:  Histochemistry and Cell Biology Vol. 154, No. 2 ( 2020-08), p. 189-195
    Details
    In: Histochemistry and Cell Biology, Springer Science and Business Media LLC, Vol. 154, No. 2 ( 2020-08), p. 189-195
    Abstract: Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this study, we evaluated and correlated the SIRT1 expression with patients’ tumor characteristics in endometrioid and clear-cell cancer of the uterus. 65 paraffin-embedded samples of patients with endometrial and clear-cell cancer of the uterus were immunohistochemically stained and SIRT1 expression was evaluated by immunoreactive score. The results were correlated to clinical and pathological tumor characteristics as well as to the expression of ARID1A and β-Catenin. The staining was significantly more intensive in uterine endometrioid carcinoma compared to uterine clear-cell carcinoma ( p  = 0.007). The expression of SIRT1 correlated significantly with the membranous expression of β-Catenin ( p  = 0.028) and ARID1A ( p  = 0.021). Patients with positive Sirtuin1 expression had a significantly better progression-free survival ( p  = 0.042), the overall survival showed a trend towards a better prognosis ( p  = 0.070). SIRT1 expression seems to be associated with improved progression-free survival in uterine cancer (endometrioid and clear-cell) and is correlated to the tumor suppressors β-Catenin and ARID1A. Further studies are necessary to elucidate the role of SIRT1 in uterine and ovarian cancer and its potential as a therapeutic target.
    Type of Medium: Online Resource
    ISSN: 0948-6143 , 1432-119X
    URL: Article
    DOI: 10.1007/s00418-020-01873-x
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1398345-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Local Resection of Primary Tumor in Upfront Stage IV Breast Cancer
    S. Karger AG ; 2016
    In:  Breast Care Vol. 11, No. 6 ( 2016), p. 411-417
    Details
    In: Breast Care, S. Karger AG, Vol. 11, No. 6 ( 2016), p. 411-417
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study aimed to identify the association of local surgery of the primary tumor in metastatic breast cancer (MBC) patients with overall survival (OS) and prognostic factors. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 Patients with primary MBC (1990-2006) were included in our retrospective analysis (n = 236). 83.1% had surgery for the primary tumor. OS was evaluated using Kaplan-Meier estimates. Predictive factors for OS were determined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Median follow-up was 123 months for all patients still alive at the time of analysis. In univariate analysis, patients with surgery of the primary tumor had significantly prolonged OS (28.9 vs. 23.9 months). Within the surgery group, patients with MBC limited to 1 organ system had a better outcome (39.3 vs. 24.9 months), as did asymptomatic patients. Independent risk factors for shorter OS were hormone receptor negativity, symptoms, and involvement of ≥ 1 organ system. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Patient selection for local therapy was confounded by a more favorable profile and a lesser tumor burden before surgery, which might implicate a bias. Nevertheless, our univariate results indicate that local surgery of the primary tumor in MBC patients could be considered as part of the therapeutic regimen in selected patients. However, larger patient numbers are needed to prove these findings in the multivariate model.
    Type of Medium: Online Resource
    ISSN: 1661-3791 , 1661-3805
    URL: Article
    DOI: 10.1159/000453573
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2205941-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Induction of apoptosis in breast cancer cells in vitro by Fas ligand reverse signaling
    Springer Science and Business Media LLC ; 2018
    In:  Journal of Cancer Research and Clinical Oncology Vol. 144, No. 2 ( 2018-2), p. 249-256
    Details
    In: Journal of Cancer Research and Clinical Oncology, Springer Science and Business Media LLC, Vol. 144, No. 2 ( 2018-2), p. 249-256
    Type of Medium: Online Resource
    ISSN: 0171-5216 , 1432-1335
    URL: Article
    DOI: 10.1007/s00432-017-2551-y
    RVK:
    XA 52301
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1459285-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Galectin-8 and -9 as prognostic factors for cervical cancer
    Springer Science and Business Media LLC ; 2022
    In:  Archives of Gynecology and Obstetrics Vol. 306, No. 4 ( 2022-04-04), p. 1211-1220
    Details
    In: Archives of Gynecology and Obstetrics, Springer Science and Business Media LLC, Vol. 306, No. 4 ( 2022-04-04), p. 1211-1220
    Abstract: Galectins are carbohydrate-binding proteins with multiple effects on cell biology. Research shows that they play an important role in tumor development and progression. Therefore, in this study, the presence of Galectin-8 and -9 (Gal), both already known as prognostic factors in other tumor entities, were investigated in cervical cancer. Our aim was to examine the association of Gal-8 and -9 expression with histopathological markers and survival of the patients. Methods Gal-8 and -9 expression was investigated in 250 cervical cancer samples by immunohistochemistry. The staining was evaluated using the immunoreactive score (IRS). The results were correlated to clinical and pathological data. The correlation of Gal-8 and -9 expression with overall and relapse-free survival was analyzed. Results Expression of Gal-8 was associated with negative N-status and lower FIGO status. Detection of Gal-9 was connected to negative N-status and lower grading regarding all specimens. A correlation of Gal-9 with lower FIGO status was detected for squamous cell carcinoma (SCC) only. Expression of Gal-8 was associated with relapse-free survival of SCC patients in a positive manner. Gal-9 expression was associated with better overall survival. Conclusion Our results suggest that expression of both galectins is inversely associated with tumor stage and progression. Gal-8 expression is associated with relapse-free survival of patients with SCC, while presence of Gal-9 in cervical cancer is associated with a better prognosis in regard of overall survival.
    Type of Medium: Online Resource
    ISSN: 1432-0711
    URL: Article
    DOI: 10.1007/s00404-022-06449-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1458450-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Expression of Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16 in cervical dysplasia
    Future Medicine Ltd ; 2017
    In:  Future Oncology Vol. 13, No. 2 ( 2017-01), p. 145-157
    Details
    In: Future Oncology, Future Medicine Ltd, Vol. 13, No. 2 ( 2017-01), p. 145-157
    Abstract: Aim: Cervical intraepithelial neoplasia (CIN) is commonly divided into three grades. Guidelines increasingly recommend surgery only in CIN 3 lesions. We investigated markers to evaluate differences in CIN 2 and 3 lesions as well as possible predictors for regression/progression in CIN 2 lesions. Materials & methods: Biopsies (n = 128) of healthy cervical tissue and CIN 1–3 were stained for Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16. Results: We observed significant differences between CIN 2 and 3 lesions for Sialyl Lewis a, Sialyl Lewis x, Gal-3, Gal-7, STMN1 and p16. Expression of Sialyl Lewis a was significantly higher in CIN 2 patients who progressed during follow-up. Conclusion: Significant differences in marker expression support the differentiation of CIN 2 and 3. Lewis a may help to predict progression/regression in CIN 2 patients.
    Type of Medium: Online Resource
    ISSN: 1479-6694 , 1744-8301
    URL: Article
    DOI: 10.2217/fon-2016-0259
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2017
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Prognostic impact of residual disease in simultaneous additional excision specimens after one-step breast conserving therapy with negative final margin status in primary breast cancer
    Elsevier BV ; 2018
    In:  European Journal of Surgical Oncology Vol. 44, No. 9 ( 2018-09), p. 1318-1323
    Details
    In: European Journal of Surgical Oncology, Elsevier BV, Vol. 44, No. 9 ( 2018-09), p. 1318-1323
    Type of Medium: Online Resource
    ISSN: 0748-7983
    URL: Article
    DOI: 10.1016/j.ejso.2018.06.014
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2002481-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Sex Specific Expression of Interleukin 7, 8 and 15 in Placentas of Women with Gestational Diabetes
    MDPI AG ; 2020
    In:  International Journal of Molecular Sciences Vol. 21, No. 21 ( 2020-10-28), p. 8026-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 21 ( 2020-10-28), p. 8026-
    Abstract: Gestational diabetes mellitus (GDM) is known to increase the risk for feto-maternal complications during pregnancy. A state of low-grade inflammation, with elevated levels of proinflammatory molecules, similar to patients with obesity or diabetes mellitus type 2 has also been partly described in GDM. The placenta, as unique interface between mother and fetus, is not only passively affected by changes in one of these organisms, but also acts as a modulator by expressing hormones and cytokines. This study aimed to investigate the expression of the proinflammatory cytokines Interleukin (IL) 7, 8 and 15 in GDM in placental tissue. A total number of 80 placentas were included (40 GDM/40 control group). The expression of IL-7, 8 and 15 was investigated in extravillous trophoblast (EVT) and syncytiotrophoblast (SCT) by immunohistochemistry and immunofluorescence double staining. The immunohistochemical staining was evaluated with the semiquanitfied immunoreactive score (IRS). While the expression IL-15 was significantly upregulated in EVTs of women with GDM. The expression of IL-8 was significantly decreased in EVT of the GDM group. Furthermore, significant fetal sex specific differences were detectable in all three cytokines. Our findings suggest an involvement of the investigated cytokines in the maintenance of a state of chronic low-grade inflammation on placental level in patients suffering from GDM.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms21218026
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer
    Springer Science and Business Media LLC ; 2022
    In:  Archives of Gynecology and Obstetrics Vol. 305, No. 6 ( 2022-06), p. 1559-1572
    Details
    In: Archives of Gynecology and Obstetrics, Springer Science and Business Media LLC, Vol. 305, No. 6 ( 2022-06), p. 1559-1572
    Abstract: Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. Furthermore, RSV targets Sirtuin1 (Sirt1), a histone deacetylase. Study design 123 tissue samples of patients with serous or mucinous ovarian cancer were examined for expression of Sirt1 and RXR. Ovarian cell lines were treated with RSV and consequences on viability and apoptosis were evaluated. The influence of RSV to Sirt1 and RXR expression was analyzed by western blotting Results A correlation of nuclear Sirt1 and RXRα expression could be detected ( p  = 0.006). Co-expression of nuclear RXRα and cytoplasmic ( p  = 0.026) or nuclear ( p  = 0.041) Sirt1 was associated with significantly increased overall survival in advanced tumour stages. Viability was decreased in all cell lines after stimulation with resveratrol, while cell apoptosis was increased. RSV treatment led to significant lower Sirt1 expression in A2780 cells ( p  = 0.025) and significant increased RXR expression in cisA2780 cells ( p  = 0.012) Conclusion In order to use RSV as medical target, studies could be developed to improve the understanding of drug resistance mechanisms and consequently improve treatment outcome.
    Type of Medium: Online Resource
    ISSN: 1432-0711
    URL: Article
    DOI: 10.1007/s00404-021-06262-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1458450-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...