In:
Pediatrics International, Wiley, Vol. 61, No. 4 ( 2019-04), p. 388-392
Abstract:
Parenteral nutrition ( PN ) has been widely used in preterm infants. The lipid solutions used for PN , however, are associated with oxidative stress and morbidity. The aim of this study was to compare the effectiveness of a new‐generation lipid emulsion ( SMOFL ipid) and olive‐oil based lipid emulsion for prevention of PN ‐associated oxidative damage. Methods Preterm infants 〈 32 weeks of gestational age were included in this prospective randomized study. All infants were randomized to SMOF lipid or olive‐oil based lipid emulsion (ClinOleic). Lipid peroxidation products were evaluated in all infants. In addition, total antioxidant capacity ( TAC ), and both pro‐ and anti‐inflammatory cytokines were studied at days 0, 7 and 14. Results A total of 89 infants ( SMOF lipid, n = 42; ClinOleic, n = 47) were enrolled. TAC was higher in the SMOF lipid group compared with the ClinOleic group at all time points, and the difference on day 7 was statistically significant. Although the anti‐inflammatory cytokine interleukin‐10 was higher in the SMOF lipid group, this difference was not significant. Bronchopulmonary dysplasia ( BPD ) was lower in the SMOF lipid group (14.1%) than in the ClinOleic group (31.2%), but this finding was non‐significant p 〉 0.05. The rate of severe BPD was significantly lower in the SMOF lipid group. Conclusion To our best of knowledge, this is the first study to suggest that SMOF lipid might decrease oxidative damage and oxidative‐stress‐associated morbidity compared with olive oil‐based emulsion in preterm infants.
Type of Medium:
Online Resource
ISSN:
1328-8067
,
1442-200X
DOI:
10.1111/ped.2019.61.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2008621-0
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