In:
Annual Review of Nursing Research, Springer Publishing Company, Vol. 29, No. 1 ( 2011-12), p. 261-280
Abstract:
Gastrointestinal (GI) symptoms including nausea, vomiting, diarrhea, constipation, abdominal discomfort/pain, and heartburn are ubiquitous and as such are often the focus of nursing interventions. The etiologies of these symptoms include GI pathology (e.g., cancer, inflammation), dietary factors (e.g., lactose intolerance), infection, stress, autonomic nervous system dysregulation, medications, as well as a host of diseases outside the GI tract. This review focuses on a common condition (irritable bowel syndrome [IBS]) that is linked with both bowel pattern and abdominal discomfort/pain symptoms. Family and twin studies give evidence for a role of genetic factors in IBS. Whether genes are directly associated with IBS or influence disease risk indirectly by modulating the response to environmental factors remains unknown at this time. Given the multifactorial nature of IBS, it is unlikely that a single genetic factor is responsible for IBS. In addition, gene–gene (epistatic) interactions are also likely to play a role. Four genes coding for proteins involved in neurotransmission (i.e., the serotonin reuptake transporter [SERT] , tryptophan hydroxylase [TPH], alpha
Type of Medium:
Online Resource
ISSN:
0739-6686
,
1944-4028
DOI:
10.1891/0739-6686.29.261
Language:
English
Publisher:
Springer Publishing Company
Publication Date:
2011
Permalink