In:
ChemBioChem, Wiley, Vol. 24, No. 10 ( 2023-05-16)
Abstract:
Four new Co II complexes, [Co(bpy) 2 (acac)]Cl ( 1 ), [Co(phen) 2 (acac)]Cl ( 2 ), [Co(bpy) 2 (cur)]Cl ( 3 ), [Co(phen) 2 (cur)]Cl ( 4 ), where bpy=2,2’‐bipyridine ( 1 and 3 ), phen=1,10‐phenanthroline ( 2 and 4 ), acac = acetylacetonate ( 1 and 2 ), cur=curcumin monoanion ( 3 and 4 ) have been designed, synthesized and fully characterized. The X‐ray crystal structures of 1 and 2 indicated that the CoN 4 O 2 core has a distorted octahedral geometry. The photoactivity of these complexes was tuned by varying the π conjugation in the ligands. Curcumin complexes 3 and 4 had an intense absorption band near 435 nm, which made them useful as visible‐light photodynamic therapy agents; they also showed fluorescence with λ em ≈565 nm. This fluorescence was useful for studying their intracellular uptake and localization in MCF‐7 breast cancer cells. The acetylacetonate complexes ( 1 and 2 ) were used as control complexes to understand the role of curcumin. The white‐light‐triggered anticancer profiles of the cytosol targeting complexes 3 and 4 were investigated in detail. These non‐dark toxic complexes displayed significant apoptotic photo‐cytotoxicity (under visible light) against MCF‐7 cells through ROS generation. The control complexes 1 and 2 did not induce significant cell death in the light or dark. Interestingly, 1‐4 produced a remarkable antibacterial response upon light exposure. Overall, the reported results here can increase the boundary of the Co II ‐based anticancer and antibacterial drug development.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.202300033
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2020469-3
SSG:
12
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