In:
European Journal of Immunology, Wiley, Vol. 43, No. 10 ( 2013-10), p. 2566-2576
Abstract:
Hantaviruses are emerging human pathogens. They induce an unusually strong antiviral response of human HLA class I ( HLA ‐ I ) restricted CD 8 + T cells that may contribute to tissue damage and hantavirus‐associated disease. In this study, we analyzed possible hantaviral mechanisms that enhance the HLA ‐ I antigen presentation machinery. Upon hantavirus infection of various human and primate cell lines, we observed transactivation of promoters controlling classical HLA molecules. Hantavirus‐induced HLA ‐ I upregulation required proteasomal activity and was associated with increased TAP expression. Intriguingly, human DC s acquired the capacity to cross‐present antigen upon hantavirus infection. Furthermore, knockdown of TIR domain containing adaptor inducing IFN ‐β or retinoic acid inducible gene I abolished hantavirus‐driven HLA ‐ I induction. In contrast, M y D 88‐dependent viral sensors were not involved in HLA ‐ I induction. Our results show that hantaviruses strongly boost the HLA ‐ I antigen presentation machinery by mechanisms that are dependent on both retinoic acid inducible gene I and TIR domain containing adaptor inducing IFN ‐β.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201243066
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1491907-2
Permalink