In:
Therapeutic Apheresis and Dialysis, Wiley, Vol. 27, No. 2 ( 2023-04), p. 353-360
Abstract:
Peritoneal fibrosis may progress in peritoneal dialysis (PD) patients to a fatal clinical condition called encapsulating peritoneal sclerosis (EPS). Transforming growth factor (TGF)‐β plays a pivotal role in the pathogenesis of peritoneal fibrosis. We aimed to investigate the association among polymorphisms in the gene encoding TGF‐β1 , which were −509C/T (rs1800469), +869T/C (rs1982073), and +915G/C (rs1800471) in EPS patients. Methods A total of 16 PD patients who were clinically and radiologically diagnosed with EPS were enrolled and 22 age‐ and gender‐matched PD patients were selected as the non‐EPS group. Results G allele frequency at the rs1800471 gene polymorphism was significantly higher in the EPS group than non‐EPS group ( p = 0.005). Interestingly, the non‐EPS group patients had CC or CG polymorphisms. Conclusion C allele in TGF‐β1 rs1800471 gene polymorphisms might indicate a protective feature in EPS development. Knowing the presence of polymorphism may be effective in selecting renal replacement therapy in patients.
Type of Medium:
Online Resource
ISSN:
1744-9979
,
1744-9987
DOI:
10.1111/1744-9987.13913
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2010864-3
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