In:
QSAR & Combinatorial Science, Wiley, Vol. 25, No. 11 ( 2006-11), p. 1063-1068
Abstract:
In this paper, we present a new method and process for combinatorial solid phase library synthesis. The new method, we call “Syn & Sort”, combines the advantages of the directed sorting technique with those of miniaturized parallel synthesis. Directed sorting steps were realized by combination of two encoding principles: spatially resolved encoding was used for a carrier chip, bearing 60 solid phase units and an individual barcode‐marker for each carrier. Solid phase supports were made of glass with a magnetic core coated with functionalized polymer support. Sixty synthesis units were arranged on each carrier chip using the magnetic “clip board” principle. No special synthesis equipment is necessary because all carriers can be used in standard laboratory equipment. Syn & Sort was applied for the synthesis of a pentamer‐peptide library. The design and construction of the magnetic synthesis support, carrier chips, and handling device are given. Here, we provide proof of principle of the new Syn & Sort method and introduce it to the scientific and commercial research.
Type of Medium:
Online Resource
ISSN:
1611-020X
,
1611-0218
DOI:
10.1002/qsar.200640113
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2537668-8
detail.hit.zdb_id:
2010584-8
SSG:
12
SSG:
15,3
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