In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 87, No. 1 ( 1978-01), p. 19-27
Abstract:
D-Ser (TBU) 6 LH-RH 1–9 (EA) 10 (HOE 766) a highly active LH-RH analogue, was studied with regard to its effects on the release of follicle stimulating hormone (FSH), luteinizing hormone (LH) and oestradiol-17β (Oe 2 ) during the follicular phase of the menstrual cycle. Forty-two regularly menstruating women were allowed to five different treatment groups with different doses (1.25 μg; 2.5 μg; 5.0 μg; 10.0 μg; 20.0 μg) of HOE 766 given as intravenous bolus injections and the plasma concentrations of FSH, LH and Oe 2 were measured up to 24 h after injection using specific radioimmunoassays. In the majority of cases, peak values of both FSH and LH occurred 4 h after injection being significantly different from pre-injection levels ( P 〈 0.02 in the 1.25 μg treatment group, P 〈 0.005 for the other treatment groups). Statistical analysis of maximum values as well as the absolute and relative increase in the different treatment groups revealed a dose-dependent effect of HOE 766. Maximum values of Oe 2 occurred 8 h after injection and were found to be significantly different from pre-injection levels ( P 〈 0.005). However, no dose dependent effect was observed. It was concluded that HOE 766 is a potent and long-acting stimulator of FSH, LH and Oe 2 release in women. The effect of HOE 766 is dose dependent for FSH and LH but not for Oe 2 .
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0870019
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1978
detail.hit.zdb_id:
1485160-X
Permalink
