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  • 1
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 10 ( 2019-7-19)
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606827-8
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  • 2
    In: Critical Care, Springer Science and Business Media LLC, Vol. 25, No. 1 ( 2021-12)
    Abstract: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration : ClinicalTrials.gov NCT02010073 .
    Type of Medium: Online Resource
    ISSN: 1364-8535
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2051256-9
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  • 3
    Online Resource
    Online Resource
    American Physical Society (APS) ; 2014
    In:  Physical Review D Vol. 89, No. 7 ( 2014-4-18)
    In: Physical Review D, American Physical Society (APS), Vol. 89, No. 7 ( 2014-4-18)
    Type of Medium: Online Resource
    ISSN: 1550-7998 , 1550-2368
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2014
    detail.hit.zdb_id: 2844732-3
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  • 4
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2012
    In:  Journal of Clinical Oncology Vol. 30, No. 15_suppl ( 2012-05-20), p. 2007-2007
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. 2007-2007
    Abstract: 2007 Background: Age is the most important therapy-independent prognostic factor in patients with primary central nervous system lymphoma (PCNSL). Here we aimed at providing an analysis of the impact of higher age on response to therapy, toxicity, and survival in the largest PCNSL trial ever performed to date. Methods: Response to therapy, toxicity and survival of PCNSL patients enrolled in the G-PCNSL-SG-1 trial evaluating the role of radiotherapy after high-dose methotrexate (HD-MTX)-based chemotherapy were monitored. Subjects aged 70 or more were compared to younger patients. Results: Of all eligible patients (n=526), 126 (24%) were aged 70 or more. In the per protocol population, 66 of 318 patients (21%) were at least 70 years old. Among the eligible patients, the rate of complete and partial responses (CR+PR) to HD-MTX-based chemotherapy was 44% in the elderly compared to 57% in the younger patients (p=0.016). A higher rate of grade III/IV leukopenia was observed in the elderly (34% versus 21%, p=0.007). Also, death on therapy was more frequent (18% versus 11%; p=0.027) in these patients. In contrast, there was no other major age-dependent toxicity. Survival analyses revealed shorter progression-free survival (PFS) (4.0 versus 7.7 months, p=0.014) and overall survival (OS) (12.5 versus 26.2 months, p 〈 0.001) in the elderly population. The PFS of CR patients was 35.0 months in younger patients compared to 16.1 in the elderly (p=0.024). Salvage therapy was used less commonly in elderly patients. When salvage WBRT was applied in patients who had failed on HD-MTX-based chemotherapy, there was no association between age and survival (p=0.633). Conclusions: Elderly PCNSL patients have a lower response rate and higher mortality on HD-MTX-based chemotherapy. Their PFS is shorter and they receive less salvage therapy which may contribute to the poor prognosis.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2012
    detail.hit.zdb_id: 2005181-5
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  • 5
    In: Journal of Physics G: Nuclear and Particle Physics, IOP Publishing, Vol. 50, No. 3 ( 2023-03-01), p. 030501-
    Abstract: High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF’s physics potential.
    Type of Medium: Online Resource
    ISSN: 0954-3899 , 1361-6471
    RVK:
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 1472964-7
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  • 6
    Online Resource
    Online Resource
    IOP Publishing ; 2022
    In:  Physica Scripta Vol. 97, No. 5 ( 2022-05-01), p. 054002-
    In: Physica Scripta, IOP Publishing, Vol. 97, No. 5 ( 2022-05-01), p. 054002-
    Abstract: The recent muon g − 2 result from Fermilab combined with the Brookhaven result, strongly points to new physics beyond the Standard Model which can be well described by the electroweak sector of supersymmetry if the masses of the sleptons and some of the electroweak gauginos are in the few hundred GeV range. However, the Higgs boson mass measurement at 125 GeV indicates a mass scale for squarks which lies in the few TeV region indicating a split mass spectrum between squarks and sleptons. This apparent puzzle is resolved in a natural way in gluino-driven radiative breaking of the electroweak symmetry where radiative breaking is driven by a large gluino mass and the gluino color interactions lead to a large splitting between the squarks and the sleptons. We show that an analysis without prejudice using an artificial neural network also leads to the gluino-driven radiative breaking. We use a set of benchmarks and a deep neural network analysis to test the model for the discovery of light sleptons and sneutrinos at HL-LHC and HE-LHC.
    Type of Medium: Online Resource
    ISSN: 0031-8949 , 1402-4896
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 1477351-X
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  • 7
    Online Resource
    Online Resource
    IOP Publishing ; 2022
    In:  Journal of Cosmology and Astroparticle Physics Vol. 2022, No. 04 ( 2022-04-01), p. 042-
    In: Journal of Cosmology and Astroparticle Physics, IOP Publishing, Vol. 2022, No. 04 ( 2022-04-01), p. 042-
    Abstract: The recent analysis from the SH0ES collaboration has confirmed the existence of a Hubble tension between measurements at high redshift ( z 〉 1000) and at low redshift ( z 〈 1) at the 5 σ level with the low redshift measurement giving a higher value. In this work we propose a particle physics model that can help alleviate the Hubble tension via an out-of-equilibrium hidden sector coupled to the visible sector. The particles that populate the dark sector consist of a dark fermion, which acts as dark matter, a dark photon, a massive scalar and a massless pseudo-scalar. Assuming no initial population of particles in the dark sector, feeble couplings between the visible and the hidden sectors via kinetic mixing populate the dark sector even though the number densities of hidden sector particles never reach their equilibrium distribution and the two sectors remain at different temperatures. A cosmologically consistent analysis is presented where a correlated evolution of the visible and the hidden sectors with coupled Boltzmann equations involving two temperatures, one for the visible sector and the other for the hidden sector, is carried out. The relic density of the dark matter constituted of dark fermions is computed in this two-temperature formalism. As a consequence, BBN predictions are upheld with a minimal contribution to Δ N eff . However, the out-of-equilibrium decay of the massive scalar to the massless pseudo-scalar close to the recombination time causes an increase in Δ N eff that can help weaken the Hubble tension.
    Type of Medium: Online Resource
    ISSN: 1475-7516
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2104147-7
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  • 8
    Online Resource
    Online Resource
    Hogrefe Publishing Group ; 2000
    In:  Zeitschrift für Gerontopsychologie & -psychiatrie Vol. 13, No. 2 ( 2000-06), p. 61-77
    In: Zeitschrift für Gerontopsychologie & -psychiatrie, Hogrefe Publishing Group, Vol. 13, No. 2 ( 2000-06), p. 61-77
    Abstract: Zusammenfassung: Zur Beantwortung der Fragen, ob psychische Leistungen bei Personen mit altersassoziierten Gedächtnisstörungen (AAMI) und solchen mit ausschließlich subjektiven Gedächtnisbeeinträchtigungen (SUBE) durch positive Stimmung beeinflußt werden, wurden Pbn mit AAMI (n = 24) und SUBE (n = 24) mit beschwerdefreien Senioren (n = 24) hinsichtlich habituellem psychischem Befinden, experimentell induzierter positiver Stimmung und deren Wirkung auf Gedächtnisleistungen verglichen. Die Ergebnisse zeigen unauffälliges habituelles emotionales Befinden und negativere habituelle Leistungsbeschreibung der Gruppen AAMI und SUBE. Pbn mit AAMI beschreiben in der Testsituation eine schlechtere aktuelle Stimmung und einen schlechteren aktuellen Leistungszustand. Ihre Gedächtnisleistungen sind dabei nur teilweise schlechter. Pbn mit ausschließlich subjektiven Gedächtnisbeschwerden beschreiben in der Testsituation einen schlechteren aktuellen Gedächtnisleistungszustand. Sie weisen verstärkt depressive Symptome auf. Die experimentelle Stimmungsinduktion bewirkte alleine im Selbsturteil die beabsichtigte Stimmungsverbesserung. Physiologische Variablen und Gedächtnisleistungen wurden dadurch nicht beeinflußt. Die Befunde legen den Schluß nahe, daß Personen mit AAMI Besonderheiten hinsichtlich der Informationsverarbeitung aufweisen, während Senioren mit ausschließlich subjektiven Gedächtnisbeschwerden hinsichtlich Depressivität eine Risikogruppe sein könnten.
    Type of Medium: Online Resource
    ISSN: 1011-6877 , 1664-2899
    RVK:
    RVK:
    Language: German
    Publisher: Hogrefe Publishing Group
    Publication Date: 2000
    detail.hit.zdb_id: 2091178-6
    detail.hit.zdb_id: 624741-6
    SSG: 5,2
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  • 9
    Online Resource
    Online Resource
    IOP Publishing ; 2013
    In:  Journal of Cosmology and Astroparticle Physics Vol. 2013, No. 11 ( 2013-11-15), p. 039-039
    In: Journal of Cosmology and Astroparticle Physics, IOP Publishing, Vol. 2013, No. 11 ( 2013-11-15), p. 039-039
    Type of Medium: Online Resource
    ISSN: 1475-7516
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2013
    detail.hit.zdb_id: 2104147-7
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2018
    In:  The European Physical Journal C Vol. 78, No. 3 ( 2018-3)
    In: The European Physical Journal C, Springer Science and Business Media LLC, Vol. 78, No. 3 ( 2018-3)
    Type of Medium: Online Resource
    ISSN: 1434-6044 , 1434-6052
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1397769-6
    detail.hit.zdb_id: 1459069-4
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