In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2022-2-8), p. e1010011-
Abstract:
Atlantic Halibut ( Hippoglossus hippoglossus ) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome 13 as the Y chromosome due to sequence divergence between sexes and segregation of sex genotypes in pedigrees. Linkage analysis revealed that all chromosomes exhibit heterochiasmy, i.e. male-only and female-only meiotic recombination regions (MRR/FRR). We show that FRR/MRR intervals differ in nucleotide diversity and repeat class content and that this is true also for other Pleuronectidae species. We further show that remnants of a Gypsy-like transposable element insertion on chr13 promotes early male specific expression of gonadal somatic cell derived factor ( gsdf ). Less than 4.5 MYA, this male-determining element evolved on an autosomal FRR segment featuring pre-existing male meiotic recombination barriers, thereby creating a Y chromosome. Our findings indicate that heterochiasmy may facilitate the evolution of genetic sex determination systems relying on linkage of sexually antagonistic loci to a sex-determining factor.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1010011
DOI:
10.1371/journal.pgen.1010011.g001
DOI:
10.1371/journal.pgen.1010011.g002
DOI:
10.1371/journal.pgen.1010011.g003
DOI:
10.1371/journal.pgen.1010011.g004
DOI:
10.1371/journal.pgen.1010011.g005
DOI:
10.1371/journal.pgen.1010011.t001
DOI:
10.1371/journal.pgen.1010011.t002
DOI:
10.1371/journal.pgen.1010011.s001
DOI:
10.1371/journal.pgen.1010011.s002
DOI:
10.1371/journal.pgen.1010011.s003
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10.1371/journal.pgen.1010011.s004
DOI:
10.1371/journal.pgen.1010011.s005
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10.1371/journal.pgen.1010011.s006
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10.1371/journal.pgen.1010011.s007
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10.1371/journal.pgen.1010011.s008
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10.1371/journal.pgen.1010011.s009
DOI:
10.1371/journal.pgen.1010011.s010
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10.1371/journal.pgen.1010011.s011
DOI:
10.1371/journal.pgen.1010011.s012
DOI:
10.1371/journal.pgen.1010011.s013
DOI:
10.1371/journal.pgen.1010011.s014
DOI:
10.1371/journal.pgen.1010011.s015
DOI:
10.1371/journal.pgen.1010011.s016
DOI:
10.1371/journal.pgen.1010011.s017
DOI:
10.1371/journal.pgen.1010011.s018
DOI:
10.1371/journal.pgen.1010011.s019
DOI:
10.1371/journal.pgen.1010011.s020
DOI:
10.1371/journal.pgen.1010011.s021
DOI:
10.1371/journal.pgen.1010011.s022
DOI:
10.1371/journal.pgen.1010011.s023
DOI:
10.1371/journal.pgen.1010011.s024
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2186725-2
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