In:
Clinical Physiology and Functional Imaging, Wiley, Vol. 42, No. 4 ( 2022-07), p. 250-259
Abstract:
In this study, it was aimed to compare scintigraphic split renal function (SRF) and computed tomographic (CT) kidney volumes by semiautomatic segmentation method in predicting graft functions after kidney transplantation. Methods One hundred and twelve patients (77 males, 35 females) who had a living‐donor kidney transplant between 2015 and 2017 in our centre were included in the study. While SRF was calculated with technetium‐99m‐diethylenetriaminepentaacetic acid ( 99m Tc‐DTPA) scintigraphy, CT angiography was used for volumetric calculations. Results CT‐volumetric measurements, especially renal cortical volume (RCV: 103.8 ± 20 ml) and ratio to body mass index (RCV/BMI: 4.45 ± 1.3) were found to be more significant than 99m Tc‐DTPA‐SRF in predicting graft functions. The correlations between SRF and RCV with 6th‐month estimated glomerular filtration rate (eGFR) (rSRF: 0.052, rRCV: 0.317, p = 0.041) and 1st‐year eGFR (rSRF: 0.104, rRCV: 0.374, p = 0.033) were found to be more significant in favour of RCV. The correlation between SRF/BMI and RCV/BMI with 1st‐, 6th‐ and 12th‐month eGFR (respectively, p = 0.02/0.048/0.024) were found to be more significant in favour of RCV/BMI. Although univariate analysis showed a significant relationship between most volumetric measurements and 1st‐year graft functions, in multivariate analysis only RCV [odds ratio (OR): 1.04 (1.01–1.07), p = 0.023] and RCV/BMI [OR: 2.5 (1.27–5.39), p = 0.013] showed a significant relationship between graft functions. Conclusion In our study, it was shown that CT‐based renal volumetric measurements, especially RCV and RCV/BMI, predicted graft functions more strongly than scintigraphic 99m Tc‐DTPA‐SRF.
Type of Medium:
Online Resource
ISSN:
1475-0961
,
1475-097X
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2004626-1
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