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  • 1
    Online Resource
    Online Resource
    Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome
    Springer Science and Business Media LLC ; 2013
    In:  Journal of Molecular Medicine Vol. 91, No. 7 ( 2013-7), p. 811-823
    Details
    In: Journal of Molecular Medicine, Springer Science and Business Media LLC, Vol. 91, No. 7 ( 2013-7), p. 811-823
    Type of Medium: Online Resource
    ISSN: 0946-2716 , 1432-1440
    URL: Article
    DOI: 10.1007/s00109-013-1034-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 1462132-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Abstract 12684: Development and Implementation of Blood Pressure Screening and Referral Guidelines for Community Pharmacists
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 142, No. Suppl_3 ( 2020-11-17)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 142, No. Suppl_3 ( 2020-11-17)
    Abstract: Introduction: Involvement of community pharmacists in the detection and control of hypertension improves patient care. However, current guidelines do not provide recommendations on collaboration between pharmacists and physicians, especially when and how to refer patients with undetected or uncontrolled hypertension to a physician. Methods: The German Society of Cardiology (DGK) and the ABDA - Federal Union of German Associations of Pharmacists developed and tested a structured referral guideline for community pharmacists. The project included a guideline-directed blood pressure measurement and recommendations when patients should be referred to their physician. A “red flag” referral within 4 weeks was recommended when SBP was 〉 140 mmHg or DBP 〉 90 mmHg (for subjects 〈 80 years), and 〉 160 mmHg or 〉 90 mmHg (≥80 years) in undetected individuals, or 〉 130 mmHg or 〉 80 mmHg ( 〈 65 years) and 〉 140 mmHg or 〉 80 mmHg (≥65 years) in treated patients (Figure). Results: Blood pressure was measured in 187 individuals (86 with known hypertension) from 17 community pharmacies. In patients with hypertension, poorly controlled blood pressure was detected in 55% (n=47) and were referred. A total of 16/101 subjects without a history of hypertension were referred to their physician because of uncontrolled blood pressure. Conclusion: Structured blood pressure testing in community pharmacies identified a significant number of subjects with undetected/undiagnosed hypertension and patients with poorly controlled blood pressure. Community pharmacists could play a significant role in collaboration with physicians to improve the management of hypertension.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.142.suppl_3.12684
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 1466401-X
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  • 3
    Online Resource
    Online Resource
    “Dear Doctor” Warning Letter (Rote-Hand-Brief) on Hydrochlorothiazide and Its Impact on Antihypertensive Prescription
    Deutscher Arzte-Verlag GmbH ; 2020
    In:  Deutsches Ärzteblatt international ( 2020-10-09)
    Details
    In: Deutsches Ärzteblatt international, Deutscher Arzte-Verlag GmbH, ( 2020-10-09)
    Type of Medium: Online Resource
    ISSN: 1866-0452
    URL: Article
    DOI: 10.3238/arztebl.2020.0687
    Language: German
    Publisher: Deutscher Arzte-Verlag GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 2406159-1
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  • 4
    Online Resource
    Online Resource
    Development and implementation of blood pressure screening and referral guidelines for German community pharmacists
    Wiley ; 2020
    In:  The Journal of Clinical Hypertension Vol. 22, No. 10 ( 2020-10), p. 1807-1816
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 22, No. 10 ( 2020-10), p. 1807-1816
    Abstract: Involvement of community pharmacists in the detection and control of hypertension improves patient care. However, current European or North‐American guidelines do not provide specific guidance how to implement collaboration between pharmacists and physicians, especially when and how to refer patients with undetected or uncontrolled hypertension to a physician. The German Society of Cardiology and the ABDA – Federal Union of German Associations of Pharmacists developed and tested referral recommendations for community pharmacists, embedded in two guideline worksheets. The project included a guideline‐directed blood pressure (BP) measurement and recommendations when patients should be referred to their physician. A “red flag” referral within 4 weeks was recommended when SBP was 〉 140 mm Hg or DBP 〉 90 mm Hg (for subjects 〈 80 years), and 〉 160 mm Hg or 〉 90 mm Hg (≥80 years) in undetected individuals, or 〉 130 mm Hg or 〉 80 mm Hg ( 〈 65 years) and 〉 140 mm Hg or 〉 80 mm Hg (≥65 years) in treated patients. BP was measured in 187 individuals (86 with known hypertension, mean [±SD] age 62 ± 15 years, 64% female, and 101 without known hypertension, 47 ± 16 years, 75% female) from 17 community pharmacies. In patients with hypertension, poorly controlled BP was detected in 55% (n = 47) and were referred. A total of 16/101 subjects without a history of hypertension were referred to their physician because of uncontrolled BP. Structured BP testing in pharmacies identified a significant number of subjects with undetected/undiagnosed hypertension and patients with poorly controlled BP. Community pharmacists could play a significant role in collaboration with physicians to improve the management of hypertension.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v22.10
    DOI: 10.1111/jch.14020
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2058690-5
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  • 5
    Online Resource
    Online Resource
    Use of fixed-dose combination antihypertensives in Germany between 2016 and 2020: an example of guideline inertia
    Springer Science and Business Media LLC ; 2023
    In:  Clinical Research in Cardiology Vol. 112, No. 2 ( 2023-02), p. 197-202
    Details
    In: Clinical Research in Cardiology, Springer Science and Business Media LLC, Vol. 112, No. 2 ( 2023-02), p. 197-202
    Abstract: The 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guidelines for the management of hypertension highlight the importance of fixed-dose combinations (FDC) for the treatment of hypertension and recommend initial single-pill combination therapy in almost all patients. However, data on the implementation of these recommendations in clinical practice are scarce. Methods Data from the German Institute for Drug Use Evaluation (DAPI) were analyzed and extrapolated accounting for approximately 88% of Germany’s population (approximately 73.3 million subjects). All antihypertensive (AHT) FDC products available on the German market were included in the analyses. We examined the time course of dispensed packages between January 2016 and December 2020. Results FDCs accounted for 15.4% of all AHT in 2016 and for 10.9% in 2020. While dispensing of all AHT increased slightly from year to year (2016: 143.8 million, 2020: 153.2 million packs), dispensing of FDCs decreased from 22.2 million (2016) to 16.6 million (2020) packs. Dispensing of FDCs containing hydrochlorothiazide (HCT) declined considerably from 2016 to 2020 (Q1 2016: 4.65 million, Q4 2020: 3.13 million packs). Accordingly, the proportion of HCT-containing combinations in all FDCs decreased from 85.3 to 74.2% from Q1 2016 to Q4 2020. Patients younger than 80 years were prescribed FDCs more frequently (14.6% of all AHT, based on the entire evaluation period) than patients 80 years and older (10.0%). In both age groups, this proportion decreased continuously over time. Conclusions Almost 2 years following the release of the 2018 ESC/ESH guidelines, only 10.9% of the prescribed packs of antihypertensive drugs in 2020 were FDC products, documenting underutilization of current guideline recommendations on pharmacotherapy in hypertension. Structured programs to evidence-based decision support are required to improve guideline inertia and patient outcomes, eventually. Graphical abstract
    Type of Medium: Online Resource
    ISSN: 1861-0684 , 1861-0692
    URL: Article
    DOI: 10.1007/s00392-022-01993-5
    RVK:
    XA 37040
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2218331-0
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  • 6
    Online Resource
    Online Resource
    ACE2 and SARS-CoV-2: Tissue or Plasma, Good or Bad?
    Oxford University Press (OUP) ; 2021
    In:  American Journal of Hypertension Vol. 34, No. 3 ( 2021-04-02), p. 274-277
    Details
    In: American Journal of Hypertension, Oxford University Press (OUP), Vol. 34, No. 3 ( 2021-04-02), p. 274-277
    Type of Medium: Online Resource
    ISSN: 0895-7061 , 1941-7225
    URL: Article
    DOI: 10.1093/ajh/hpaa175
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1479505-X
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  • 7
    Online Resource
    Online Resource
    ACE2, SARS-CoV-2 und RAAS-Blocker
    Springer Science and Business Media LLC ; 2021
    In:  CardioVasc Vol. 21, No. 2 ( 2021-03), p. 25-27
    Details
    In: CardioVasc, Springer Science and Business Media LLC, Vol. 21, No. 2 ( 2021-03), p. 25-27
    Type of Medium: Online Resource
    ISSN: 1617-4933 , 1618-3851
    URL: Article
    DOI: 10.1007/s15027-021-3471-y
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2167442-5
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  • 8
    Online Resource
    Online Resource
    Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage
    S. Karger AG ; 2022
    In:  American Journal of Nephrology Vol. 53, No. 7 ( 2022), p. 552-564
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 53, No. 7 ( 2022), p. 552-564
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic activation of the mineralocorticoid receptor (MR) leads to pathological processes like inflammation and fibrosis during cardiorenal disease. Modulation of immunological processes in the heart or kidney may serve as a mechanistic and therapeutic interface in cardiorenal pathologies. In this study, we investigated anti-inflammatory/-fibrotic and immunological effects of the selective nonsteroidal MR antagonists finerenone (FIN) in the deoxycorticosterone acetate (DOCA)-salt model. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Male C57BL6/J mice were uninephrectomized and received a DOCA pellet implantation (2.4 mg/day) plus 0.9% NaCl in drinking water (DOCA-salt) or received a sham operation and were orally treated with FIN (10 mg/kg/day) or vehicle in a preventive study design. Five weeks after the procedure, blood pressure (BP), urinary albumin/creatinine ratio (UACR), glomerular and tubulointerstitial damage, echocardiographic cardiac function, as well as cardiac/renal inflammatory cell content by FACS analysis were assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 BP was significantly reduced by FIN. FACS analysis revealed a notable immune response due to DOCA-salt exposure. Especially, infiltrating renal RORγt γδ-positive T cells were upregulated, which was significantly ameliorated by FIN treatment. This was accompanied by a significant reduction of UACR in FIN-treated mice. In the heart, FIN reduced DOCA-salt-induced cardiac hypertrophy, cardiac fibrosis and led to an improvement of the global longitudinal strain. Cardiac actions of FIN were not associated with a regulation of cardiac RORγt γδ-positive T cells. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 The present study shows cardiac and renal protective effects of FIN in a DOCA-salt model. The cardiorenal protection was accompanied by a reduction of renal RORγt γδ T cells. The observed actions of FIN may provide a potential mechanism of its efficacy recently observed in clinical trials.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000524940
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1468523-1
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  • 9
    Online Resource
    Online Resource
    Toxicity and nicotinic acetylcholine receptor interaction of imidacloprid and its metabolites in Apis mellifera (Hymenoptera: Apidae)
    Wiley ; 2001
    In:  Pest Management Science Vol. 57, No. 7 ( 2001-07), p. 577-586
    Details
    In: Pest Management Science, Wiley, Vol. 57, No. 7 ( 2001-07), p. 577-586
    Abstract: Acute oral and contact toxicity tests of imidacloprid, an insecticide acting agonistically on nicotinic acetylcholine receptors (nAChR), to adult honeybees, Apis mellifera L var carnica , were carried out by seven different European research facilities. Results indicated that the 48‐h oral LD 50 of imidacloprid is between 41 and 〉 81 ng per bee, and the contact LD 50 between 49 and 102 ng per bee. The ingested amount of imidacloprid‐containing sucrose solution decreased with increasing imidacloprid concentrations and may be attributed to dose‐related sub‐lethal intoxication symptoms or to antifeedant responses. Some previously reported imidacloprid metabolites occuring at low levels in planta after seed dressing, ie olefine‐, 5‐OH‐ and 4,5‐OH‐imidacloprid, showed lower oral LD 50 values ( 〉 36, 〉 49 and 159 ng per bee, respectively) compared with the concurrently tested parent molecule (41 ng per bee). The urea metabolite and 6‐chloronicotinic acid (6‐CNA) exhibited LD 50 values of 〉 99 500 and 〉 121 500 ng per bee, respectively. The pharmacological profile of the [ 3 H]imidacloprid binding site in honeybee head membrane preparations is consistent with that anticipated for a nAChR. IC 50 values for the displacement of [ 3 H]imidacloprid by several metabolites such as olefine, 5‐OH‐, 4,5‐OH‐imidacloprid, urea and 6‐CNA were 0.45, 24, 6600, 〉 100 000, and 〉 100 000 n M , respectively. Displacement of [ 3 H]imidacloprid by imidacloprid revealed an IC 50 value of 2.9 n M , thus correlating well with the observed acute oral toxicity of the compounds in honeybees. Neurons isolated from the antennal lobe of A mellifera and subjected to whole‐cell voltage clamp electrophysiology responded to the application of 100 µ M acetylcholine with a fast inward current of between 30 and 1600 pA at −70 mV clamp potential. Imidacloprid and two of the metabolites (olefine‐ and 5‐OH‐imidacloprid) acted agonistically on these neurons, whereas the others did not induce currents at test conencentrations up to 3 m M . The electrophysiological data revealed Hill coefficients of approximately 1, indicating a single binding site responsible for an activation of the receptor and no direct cooperativity or allosteric interaction with a second binding site. © 2001 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v57:7
    DOI: 10.1002/ps.331
    Language: English
    Publisher: Wiley
    Publication Date: 2001
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Diamide insecticide resistance in transgenic Drosophila and Sf9‐cells expressing a full‐length diamondback moth ryanodine receptor carrying an I4790M mutation
    Wiley ; 2022
    In:  Pest Management Science Vol. 78, No. 3 ( 2022-03), p. 869-880
    Details
    In: Pest Management Science, Wiley, Vol. 78, No. 3 ( 2022-03), p. 869-880
    Abstract: Resistance to diamide insecticides in Lepidoptera is known to be caused primarily by amino acid changes on the ryanodine receptor (RyR). Recently, two new target site mutations, G4946V and I4790M, have emerged in populations of diamondback moth, Plutella xylostella , as well as in other lepidopteran species, and both mutations have been shown empirically to decrease diamide efficacy. Here, we quantify the impact of the I4790M mutation on diamide activation of the receptor, as compared to alterations at the G4946 locus. RESULTS I4790M when introduced into P. xylostella RyR expressed in an insect‐derived Sf9 cell line was found to mediate just a ten‐fold reduction in chlorantraniliprole efficacy (compared to 104‐ and 146‐fold reductions for the G4946E and G4946V variants, respectively), whilst in the field its presence is associated with a ≥150‐fold reduction. I4790M‐mediated resistance to flubendiamide was estimated to be 〉 24‐fold. When the entire coding sequence of P. xylostella RyR was integrated into Drosophila melanogaster , the I4790M variant conferred ~4.4‐fold resistance to chlorantraniliprole and 22‐fold resistance to flubendiamide in the 3rd instar larvae, confirming that it imparts only a moderate level of resistance to diamide insecticides. Although the I4790M substitution appears to bear no fitness costs in terms of the flies' reproductive capacity, when assessed in a noncompetitive environment, it does, however, have potentially major impacts on mobility at both the larval and adult stages. CONCLUSIONS I4790M imparts only a moderate level of resistance to diamide insecticides and potentially confers significant fitness costs to the insect.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v78.3
    DOI: 10.1002/ps.6730
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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