In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2021-12-23), p. e0260730-
Abstract:
This study aimed to clarify the etiologic factors predicting acute ocular progression in SJS/TEN, and identify patients who require immediate and intensive ophthalmological treatment. We previously conducted two Japanese Surveys of SJS/TEN (i.e., cases arising between 2005–2007 and between 2008–2010), and obtained the medical records, including detailed dermatological and ophthalmological findings, of 230 patients. Acute ocular severity was evaluated as none, mild, severe, and very severe. A multi-state model assuming the Markov process based on the Cox proportional hazards model was used to elucidate the specific factors affecting the acute ocular progression. Our findings revealed that of the total 230 patients, 23 (24%) of 97 cases that were mild at initial presentation worsened to severe/very severe. Acute ocular progression developed within 3 weeks from disease onset. Exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) and younger patient age were found to be statistically significant for the progression of ocular severity from mild to severe/very severe [hazard ratio (HR) 3.83; 95% confidence interval (CI) 1.48 to 9.91] and none to severe/very severe [HR 0.98; 95% CI 0.97 to 0.99] , respectively. The acute ocular severity score at worst-condition was found to be significantly correlated with ocular sequelae. Thus, our detailed findings on acute ocular progression revealed that in 24% of SJS/TEN cases with ocular involvement, ocular severity progresses even after initiating intensive treatment, and that in younger-age patients with a history of exposure to NSAIDs, very strict attention must be given to their ophthalmological appearances.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0260730
DOI:
10.1371/journal.pone.0260730.g001
DOI:
10.1371/journal.pone.0260730.g002
DOI:
10.1371/journal.pone.0260730.g003
DOI:
10.1371/journal.pone.0260730.g004
DOI:
10.1371/journal.pone.0260730.t001
DOI:
10.1371/journal.pone.0260730.t002
DOI:
10.1371/journal.pone.0260730.t003
DOI:
10.1371/journal.pone.0260730.t004
DOI:
10.1371/journal.pone.0260730.t005
DOI:
10.1371/journal.pone.0260730.t006
DOI:
10.1371/journal.pone.0260730.s001
DOI:
10.1371/journal.pone.0260730.r001
DOI:
10.1371/journal.pone.0260730.r002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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