In:
Angewandte Chemie International Edition, Wiley, Vol. 60, No. 24 ( 2021-06-07), p. 13603-13608
Abstract:
We demonstrate a fluid–fluid phase separation in 1,2‐dimyristoyl‐ sn ‐glycero‐3‐phosphocholine (DMPC) membranes using a metal complex lipid of type [Mn(L1)] ( 1 ; HL1=1‐(2‐hydroxybenzamide)‐2‐(2‐hydroxy‐3‐formyl‐5‐hexadecyloxybenzylideneamino)ethane). Small amount of 1 produces two separated domains in DMPC, whose phase transition temperatures of lipids ( T c ) are both lower than that of the pristine DMPC. Variable temperature fluorescent microscopy for giant‐unilamellar vesicles of DMPC/ 1 hybrids demonstrates that visible phase separations remain in fluid phases up to 37 °C, which is clearly over the T c of DMPC. This provides a new dimension for the application of metal complex lipids toward controlling lipid distributions in fluid membranes.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.202102774
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
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