In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 15, No. 2 ( 1979-02), p. 157-160
Abstract:
Of 49 compounds known to have antitumor properties, 6 were found to have significant activity against Trypanosoma rhodesiense infections in mice. Activity against the African trypanosomes has not been reported previously for any of these six compounds. In order of decreasing activity these compounds were: (i) imidazole-4-carboxamide, 5-(3,3-dimethyl-1,1-triazene), (ii) inosine diglycolaldehyde, (iii) cis -diamminedichloro-platinum, (iv) streptozotocin, (v) coralyne sulfate, and (vi) 5-fluoro-2′-deoxyuridine. The percentage of “hits” (12.2%) from these known antitumor agents was approximately twice as great as when other means are employed for the selection of compounds for this test system.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.15.2.157
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1979
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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