In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 5 ( 2021-5-12), p. e0009400-
Abstract:
Orthohantaviruses, causing hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome, pose a significant public health threat worldwide. Despite the significant mortality and morbidity, effective antiviral therapeutics for orthohantavirus infections are currently unavailable. This study aimed to investigate the prevalence of HFRS-associated orthohantaviruses and identify the etiological agent of orthohantavirus outbreaks in southern Republic of Korea (ROK). Methodology/Principal findings We collected small mammals on Jeju Island during 2018–2020. We detected the Hantaan virus (HTNV)-specific antibodies and RNA using an indirect immunofluorescence assay test and reverse transcription-polymerase chain reaction on Apodemus agrarius chejuensis ( A . chejuensis ). The prevalence of anti-HTNV antibodies among rodents was 14.1%. A total of six seropositive mouse harbored HTNV RNA. The amplicon-based next-generation sequencing provided nearly full-length tripartite genomic sequences of six HTNV harbored by A . chejuensis . Phylogenetic and tanglegram analyses were conducted for inferring evolutionary relationships between orthohantaviruses with their reservoir hosts. Phylogenetic analysis showed a novel distinct HTNV genotype. The detected HTNV genomic sequences were phylogenetically related to a viral sequence derived from HFRS patient in southern ROK. Tanglegram analysis demonstrated the segregation of HTNV genotypes corresponding to Apodemus spp . divergence. Conclusions/Significance Our results suggest that A . chejuensis -borne HTNV may be a potential etiological agent of HFRS in southern ROK. Ancestral HTNV may infect A . chejuensis prior to geological isolation between the Korean peninsula and Jeju Island, supporting the co-evolution of orthohantaviruses and rodents. This study arises awareness among physicians for HFRS outbreaks in southern ROK.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009400
DOI:
10.1371/journal.pntd.0009400.g001
DOI:
10.1371/journal.pntd.0009400.g002
DOI:
10.1371/journal.pntd.0009400.g003
DOI:
10.1371/journal.pntd.0009400.g004
DOI:
10.1371/journal.pntd.0009400.g005
DOI:
10.1371/journal.pntd.0009400.t001
DOI:
10.1371/journal.pntd.0009400.t002
DOI:
10.1371/journal.pntd.0009400.t003
DOI:
10.1371/journal.pntd.0009400.s001
DOI:
10.1371/journal.pntd.0009400.s002
DOI:
10.1371/journal.pntd.0009400.s003
DOI:
10.1371/journal.pntd.0009400.s004
DOI:
10.1371/journal.pntd.0009400.s005
DOI:
10.1371/journal.pntd.0009400.s006
DOI:
10.1371/journal.pntd.0009400.s007
DOI:
10.1371/journal.pntd.0009400.s008
DOI:
10.1371/journal.pntd.0009400.s009
DOI:
10.1371/journal.pntd.0009400.s010
DOI:
10.1371/journal.pntd.0009400.s011
DOI:
10.1371/journal.pntd.0009400.r001
DOI:
10.1371/journal.pntd.0009400.r002
DOI:
10.1371/journal.pntd.0009400.r003
DOI:
10.1371/journal.pntd.0009400.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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