In:
Applied and Environmental Microbiology, American Society for Microbiology, Vol. 77, No. 5 ( 2011-03), p. 1872-1877
Abstract:
Through microarray analysis of an antibiotic-downregulator-deleted Streptomyces coelicolor Δ wblA ΔSCO1712 mutant, 28 wblA - and SCO1712-dependent genes were identified and characterized. Among 14 wblA - and SCO1712-independent genes, a carbon flux regulating 6-phosphofructokinase SCO5426 was additionally disrupted in the Δ wblA ΔSCO1712 mutant and further stimulated actinorhodin production in S. coelicolor , implying that both regulatory and precursor flux pathways could be synergistically optimized for antibiotic production.
Type of Medium:
Online Resource
ISSN:
0099-2240
,
1098-5336
DOI:
10.1128/AEM.02346-10
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2011
detail.hit.zdb_id:
223011-2
detail.hit.zdb_id:
1478346-0
SSG:
12
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