In:
Photodermatology, Photoimmunology & Photomedicine, Wiley, Vol. 33, No. 5 ( 2017-09), p. 253-259
Abstract:
Photodynamic therapy ( PDT ) has been reported as an effective alternative treatment for patients with acne. Purpose To evaluate the efficacy and safety of DL ‐ PDT in moderate to severe acne and to compare outcomes with those of laser‐assisted daylight photodynamic therapy. Methods Patients were randomly assigned to either a DL ‐ PDT group (D group) or a fractional laser‐assisted DL ‐ PDT group (F group). The outcomes were assessed by measuring acne lesion counts and severity grade at 4, 8, 12, and 16 weeks after therapy commenced. Results Twenty‐eight subjects completed the study. Compared with baseline, the mean inflammatory lesion counts significantly decreased by 36.0% in the D group and 51.8% in the F group at 8 weeks ( P 〈 .001). The mean acne severity grades in both groups significantly decreased starting at 4 weeks ( P =.012), and the beneficial effects lasted 16 weeks. Conclusion DL ‐ PDT with MAL shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.
Type of Medium:
Online Resource
ISSN:
0905-4383
,
1600-0781
DOI:
10.1111/phpp.2017.33.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2026222-X
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