In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 33, No. 1 ( 2011-01), p. 102-109
Abstract:
To evaluate the correlation of the mean and minimal apparent diffusion coefficient values (ADC mean , ADC minimal ) and dynamic magnetic resonance imaging (MRI) findings with prognostic factors in invasive ductal carcinoma. Materials and Methods A total of 107 women with invasive ductal cancer underwent breast MRI. The ADC mean and ADC minimal of the cancers were computed. MRI findings were retrospectively evaluated according to the Breast Imaging Reporting and Data System (BI‐RADS) lexicon: mass or nonmass type, mass shape, mass margin, nonmass distribution, and enhancement pattern. Histological records were reviewed for tumor size, lymph node metastasis, histologic grade, and expression of estrogen receptors (ER), progesterone receptors (PR), c‐erbB‐2(HER2), Ki‐67, and epidermal growth factor receptors (EGFR). Correlations of ADC values and MR findings with prognostic factors were determined using the Mann–Whitney U ‐test and the Kruskal–Wallis test. Results The mean ADC minimal was 0.78 ± 0.24 (×10 −3 mm 2 /s), and the mean ADC mean was 1.01 ± 0.23 (×10 −3 mm 2 /s). There was a significant correlation of the ADC mean value with ER expression ( P = 0.027) and HER2 expression ( P = 0.018). There was no significant relationship between ADC minimal and prognostic factors or between ADC mean and traditional prognostic factors, PR, Ki‐67 and EGFR. The majority of the mass type lesions were less than 5 cm in size and the majority of nonmass type lesions were more than 2 cm in size ( P = 0.022). The margin of mass was significantly associated with lymph node metastasis ( P = 0.031), ER expression ( P = 0.013), PR expression ( P = 0.036), HER2 expression ( P = 0.019), and EGRF expression ( P = 0.041). The rim internal enhancement was significantly correlated with Ki‐67 expression ( P = 0.008). Conclusion The low ADC mean value was related to positive expression of ER and negative expression of HER2. A spiculated margin was related to a good prognosis, but rim enhancement was associated with a poor prognosis. J. Magn. Reson. Imaging 2011;33:102–109. © 2010 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1497154-9
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