In:
Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 25, No. 2 ( 2008), p. 165-169
Abstract:
〈 i 〉 Background: 〈 /i 〉 β-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer’s disease (AD) from its key role in β-amyloid generation. Previous genetic association studies of 〈 i 〉 BACE1 〈 /i 〉 gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of 〈 i 〉 BACE1 〈 /i 〉 (rs638405, Val262) is associated with a risk for late-onset AD. 〈 i 〉 Methods: 〈 /i 〉 We genotyped a synonymous C/G polymorphism of 〈 i 〉 BACE1 〈 /i 〉 located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. 〈 i 〉 Results: 〈 /i 〉 The allele and genotype frequencies of 〈 i 〉 BACE1 〈 /i 〉 polymorphism were not significantly different between cases and controls (p 〉 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE- & #917;4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319–3.018). 〈 i 〉 Conclusion: 〈 /i 〉 These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE & #917;4 allele.
Type of Medium:
Online Resource
ISSN:
1420-8008
,
1421-9824
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482186-2
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