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  • 1
    Online Resource
    Online Resource
    The Association of Acute Myocardial Infarction with Pyogenic Spondylitis in Korea: A Nationwide Longitudinal Cohort Study
    Korean Society of Peripheral Nervous System ; 2022
    In:  The Nerve Vol. 8, No. 2 ( 2022-10-31), p. 71-76
    Details
    In: The Nerve, Korean Society of Peripheral Nervous System, Vol. 8, No. 2 ( 2022-10-31), p. 71-76
    Abstract: Objective: The goal of this nationally matched longitudinal study was to investigate the relationship between acute myocardial infarction (AMI) and pyogenic spondylitis (PS) in Korea.Methods: We collected patient data from the National Health Insurance Service Health Screening cohort from January 1, 2004 to December 31, 2015. PS was classified using the International Classification of Diseases codes M46.2 (osteomyelitis), M46.8 (inflammatory spondylopathy), M49.2 (enterobacterial spondylitis), and M49.3 (enterobacterial spondylitis) (spondylopathy in other infectious and parasitic diseases). The PS group had a total of 628 patients. The control group included 3,140 people. Utilizing the Kaplan-Meier technique, the groups’ AMI rates were estimated. A Cox proportional-hazards regression analysis was used to compute the hazard ratio for AMI.Results: After controlling for age and sex, the hazard ratio for AMI in the PS group was 2.241 (95% confidence interval [CI], 1.112-4.516). The adjusted hazard ratio in the PS group was 2.138 after controlling for demographics and concomitant medical conditions (95% CI, 1.056-4.318). In a subgroup analysis, the AMI percentages were substantially greater in the PS group in women over 65, those with diabetes, and in non-hypertension and non-dyslipidemia subgroups. Conclusion: This nationwide longitudinal study found that PS patients had an elevated risk of AMI.
    Type of Medium: Online Resource
    ISSN: 2465-891X
    URL: Article
    DOI: 10.21129/nerve.2022.00115
    Language: English
    Publisher: Korean Society of Peripheral Nervous System
    Publication Date: 2022
    detail.hit.zdb_id: 3148673-3
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  • 2
    Online Resource
    Online Resource
    Association of Acute Myocardial Infarction with Ossification of the Posterior Longitudinal Ligament in Korea: A Nationwide Longitudinal Cohort Study
    Korean Society of Peripheral Nervous System ; 2023
    In:  The Nerve Vol. 9, No. 1 ( 2023-04-30), p. 27-33
    Details
    In: The Nerve, Korean Society of Peripheral Nervous System, Vol. 9, No. 1 ( 2023-04-30), p. 27-33
    Abstract: Objective: This nationally matched longitudinal study aimed to investigate the relationship between acute myocardial infarction (AMI) and ossification of the posterior longitudinal ligament (OPLL) in Korea.Methods: We collected patient data from January 1, 2004 to December 31, 2015 from the National Health Insurance Service Health Screening Cohort. Patients with OPLL were defined as patients with the International Classification of Diseases, Tenth Revision code M48.8 (other specified spondylopathies) and were newly diagnosed through computed tomography imaging. The OPLL group had a total of 1,289 patients. The control group included 6,445 people. Utilizing the Kaplan-Meier technique, The incidence of AMI in both groups was estimated. A Cox proportional-hazards regression analysis was used to compute the AMI hazard ratio.Results: After controlling for age and sex, the hazard ratio of AMI in the OPLL group was 2.065 (95% confidence interval [CI], 1.228-3.474). The adjusted hazard ratio in the OPLL group was 2.209 after restricting the sample for demographics and concomitant medical conditions (95% CI, 1.311-3.721). In a subgroup analysis, the incidence of AMI was substantially greater in the OPLL group, which included women younger than 65 years and without hypertension, diabetes, or dyslipidemia.Conclusion: This nationwide longitudinal study found that patients with OPLL were at higher risk of AMI.
    Type of Medium: Online Resource
    ISSN: 2465-891X
    URL: Article
    DOI: 10.21129/nerve.2022.00248
    Language: English
    Publisher: Korean Society of Peripheral Nervous System
    Publication Date: 2023
    detail.hit.zdb_id: 3148673-3
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  • 3
    Online Resource
    Online Resource
    The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study
    MDPI AG ; 2023
    In:  Journal of Personalized Medicine Vol. 13, No. 9 ( 2023-09-05), p. 1357-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 13, No. 9 ( 2023-09-05), p. 1357-
    Abstract: The purpose of this nationwide longitudinal follow-up study is to investigate the relationship between Parkinson’s disease (PD) and congestive heart failure (CHF) patients in Korea. Patient data were collected using the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. The International Classification of Diseases 10-CM code G-20 distinguished 6475 PD patients who were enrolled in the PD group. After removing 1039 patients who were not hospitalized or attended an outpatient clinic less than twice, the total number of participants was reduced to 5436 individuals. Then, 177 patients diagnosed before 1 January 2004 were removed for relevancy, leaving us with 5259 PD patients. After case–control matching was completed using 1:5 age- and gender-coordinated matching, 26,295 people were chosen as part of the control group. The Cox proportional hazards regression analysis and the Kaplan–Meier technique were used to assess the risk of CHF in patients with Parkinson’s disease. After controlling for age and gender, the hazard ratio of CHF in the PD group was 5.607 (95% confidence interval (CI), 4.496–6.993). After that, the hazard ratio of CHF in the PD group was modified against for comorbid medical disorders, resulting in a value of 5.696 (95% CI, 4.566–7.107). In subgroup analysis, CHF incidence rates were significantly increased in the PD group compared to the control group (males and females; aged ≥ 65 and 〈 65; the non-diabetes and diabetes, hypertension and non-hypertension, and dyslipidemia and non-dyslipidemia subgroups). This nationwide longitudinal study shows a higher incidence rate of CHF in PD patients.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm13091357
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662248-8
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  • 4
    Online Resource
    Online Resource
    Association of pyogenic spondylitis with congestive heart failure in Korea: a nationwide longitudinal cohort study
    The Korean Society of Geriatric Neurosurgery ; 2022
    In:  Journal of Korean Society of Geriatric Neurosurgery Vol. 18, No. 1 ( 2022-06-30), p. 8-12
    Details
    In: Journal of Korean Society of Geriatric Neurosurgery, The Korean Society of Geriatric Neurosurgery, Vol. 18, No. 1 ( 2022-06-30), p. 8-12
    Abstract: Objective: The purpose of this nationwide longitudinal follow-up study was to investigate the risk of congestive heart failure (CHF) in pyogenic spondylitis (PS) patients in Korea.Methods: A total of 628 patients were enrolled in the PS group from January 1, 2004 to December 31, 2015 from the National Health Insurance Service Health Screening cohort. PS was identified using the International Classification of Disease, 10th revision codes M46.2–M46.8 and M49.2–M49.3. The control group consisted of 3,140 subjects with 1:5 age- and sex-stratified matching. The 12-year CHF incidence rates in the PS and control groups were compared by the Kaplan-Meier method. The hazard ratio of CHF was estimated by Cox proportional-hazards regression analysis.Results: During the 12-year follow-up period, 16 patients (2.55%) in the PS group and 43 (1.47%) in the control group developed CHF. The hazard ratio of CHF in the PS group was 6.32 (95% confidence interval [CI], 3.39–11.81) after adjusting for sex and age. The hazard ratio of CHF in the PS group was 6.49 (95% CI, 3.47–12.15) after adjusting for sex, age, and income. The hazard ratio of CHF in the PS group was 6.58 (95% CI, 3.50–12.40) after adjusting for sex, age, income, and comorbid medical disorders. In subgroup analyses, all subgroups showed higher CHF incidence rates in the PS group than in the control group.Conclusion: Our nationwide longitudinal study shows a higher incidence rate of CHF in PS patients.
    Type of Medium: Online Resource
    ISSN: 1738-981X
    URL: Article
    DOI: 10.51638/jksgn.2022.00038
    Language: English
    Publisher: The Korean Society of Geriatric Neurosurgery
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice
    Elsevier BV ; 2008
    In:  Food and Chemical Toxicology Vol. 46, No. 5 ( 2008-05), p. 1666-1673
    Details
    In: Food and Chemical Toxicology, Elsevier BV, Vol. 46, No. 5 ( 2008-05), p. 1666-1673
    Type of Medium: Online Resource
    ISSN: 0278-6915
    URL: Article
    DOI: 10.1016/j.fct.2007.12.030
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2008
    detail.hit.zdb_id: 1483645-2
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  • 6
    Online Resource
    Online Resource
    Determination of Fe 2+ and Co 2+ by a Multiple‐Target Colorimetric Chemosensor with Low Detection Limit in Aqueous Solution
    Wiley ; 2019
    In:  ChemistrySelect Vol. 4, No. 4 ( 2019-01-31), p. 1199-1204
    Details
    In: ChemistrySelect, Wiley, Vol. 4, No. 4 ( 2019-01-31), p. 1199-1204
    Abstract: A highly effective colorimetric chemosensor DPKP, N′‐(di(pyridin‐2‐yl)methylene)‐6‐hydroxypicolinohydrazide, was synthesized. DPKP sensed Fe 2+ and Co 2+ with the changes of color from colorless to blue and yellow, respectively, without severe inhibition from other metal ions. Binding interactions of DPKP with Fe 2+ and Co 2+ were analyzed to be 1:1 and 2:1 with Job plot and ESI‐MS analyses, respectively. In particular, DPKP has low detection limits for Fe 2+ (0.60 μM) and for Co 2+ (0.22 μM). In addition, DPKP could be used for quantification of Fe 2+ and Co 2+ in environmental samples.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v4.4
    DOI: 10.1002/slct.201803415
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2844262-3
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  • 7
    Online Resource
    Online Resource
    Association of Parkinson’s disease with ischemic stroke in Korea: A nationwide longitudinal cohort study in Korea
    Korean Society of Cerebrovascular Surgeons/Korean Society of Endovascular Surgery ; 2021
    In:  Journal of Cerebrovascular and Endovascular Neurosurgery Vol. 23, No. 3 ( 2021-09-30), p. 233-239
    Details
    In: Journal of Cerebrovascular and Endovascular Neurosurgery, Korean Society of Cerebrovascular Surgeons/Korean Society of Endovascular Surgery, Vol. 23, No. 3 ( 2021-09-30), p. 233-239
    Abstract: Objective: The aim of this nationwide age- and sex- matched longitudinal follow up study is to determine the risk of Parkinson’s disease (PD) associated with ischemic stroke in Korea.Methods: Patient data were collected from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS). PD was identified using the International Classification of Diseases (ICD) 10-CM code G 20. In total, 6,475 patients were enrolled in the PD group from the NHISS. After subtracting 1,039 patients who underwent hospitalization less than once or those who visited an outpatient clinic less than two times, 5,259 patients who were diagnosed after January 1, 2004 ultimately participated in this study. After case-control match was done through 1:5 age- and sex- stratified matching, 26,295 individuals were chosen as control. Kaplan-Meier method and Cox proportional hazard regression analysis were performed to evaluate the risk of ischemic stroke in PD.Results: The hazard ratio of ischemic stroke in the PD group was 3.848 (95% confidence interval (confidence interval [CI]): 3.14-4.70) after adjusting for age and sex. The adjusted hazard ratio of ischemic stroke in PD group was 3.885 (95% CI: 3.17-4.75) after adjusting for comorbidities. According to subgroup analysis, in male and female and non-diabetes and diabetes and non-hypertension and hypertension and dyslipidemia and non-dyslipidemia subgroups, ischemic stroke incidence rates were significantly higher in the PD group than those in the control group.Conclusions: This nationwide longitudinal study suggests an increased risk of ischemic stroke in PD patients.
    Type of Medium: Online Resource
    ISSN: 2234-8565 , 2287-3139
    URL: Article
    DOI: 10.7461/jcen.2021.E2021.03.007
    Language: English
    Publisher: Korean Society of Cerebrovascular Surgeons/Korean Society of Endovascular Surgery
    Publication Date: 2021
    detail.hit.zdb_id: 3019808-2
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  • 8
    Online Resource
    Online Resource
    The Relationship between Parkinson’s Disease and Acute Myocardial Infarction in Korea : A Nationwide Longitudinal Cohort Study
    Korean Neurosurgical Society ; 2022
    In:  Journal of Korean Neurosurgical Society Vol. 65, No. 4 ( 2022-07-01), p. 507-513
    Details
    In: Journal of Korean Neurosurgical Society, Korean Neurosurgical Society, Vol. 65, No. 4 ( 2022-07-01), p. 507-513
    Abstract: Objective : The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson’s disease (PD).Methods : Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD.Results : After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837–4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795–4.511). According to a subgroup analysis, in males and females aged 〈 65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control.Conclusion : Individuals with PD have a greater chance of AMI, according to this cross-national study.
    Type of Medium: Online Resource
    ISSN: 2005-3711 , 1598-7876
    URL: Article
    DOI: 10.3340/jkns.2021.0195
    Language: English
    Publisher: Korean Neurosurgical Society
    Publication Date: 2022
    detail.hit.zdb_id: 2254062-3
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  • 9
    Online Resource
    Online Resource
    Causal Effect of the 25-Hydroxyvitamin D Concentration on Cerebral Small Vessel Disease: A Mendelian Randomization Study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Stroke Vol. 54, No. 9 ( 2023-09), p. 2338-2346
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. 9 ( 2023-09), p. 2338-2346
    Abstract: Previous observational studies reported that a lower serum 25-hydroxyvitamin D [25(OH)D] concentration is associated with a higher burden of cerebral small vessel disease (cSVD). The causality of this association is uncertain, but it would be clinically important, given that 25(OH)D can be a target for intervention. We tried to examine the causal effect of 25(OH)D concentration on cSVD-related phenotypes using a Mendelian randomization approach. METHODS: Genetic instruments for each serum 25(OH)D concentration and cSVD-related phenotypes (lacunar stroke, white matter hyperintensity, cerebral microbleeds, and perivascular spaces) were derived from large-scale genome-wide association studies. We performed 2-sample Mendelian randomization analyses with multiple post hoc sensitivity analyses. A bidirectional Mendelian randomization approach was also used to explore the possibility of reverse causation. RESULTS: We failed to find any significant causal effect of 25(OH)D concentration on cSVD-related phenotypes (odds ratio [95% CI], 1.00 [0.87–1.16] , 1.01 [0.96–1.07], 1.06 [0.85–1.33] , 1.00 [0.97–1.03], 1.02 [0.99–1.04] , 1.01 [0.99–1.04] for lacunar stroke, white matter hyperintensity, cerebral microbleeds, and white matter, basal ganglia, hippocampal perivascular spaces, respectively). These results were reproduced in the sensitivity analyses accounting for genetic pleiotropy. Conversely, when we examined the effects of cSVD phenotypes on 25(OH)D concentration, cerebral microbleeds were negatively associated with 25(OH)D concentration (0.94 [0.92–0.96] ). CONCLUSIONS: Given the adequate statistical power ( 〉 0.8) of the analyses, our findings suggest that the previously reported association between 25(OH)D concentration and cSVD phenotypes might not be causal and partly attributed to reverse causation.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.123.042980
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1467823-8
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  • 10
    Online Resource
    Online Resource
    Neuropsychological Recognition Characteristics of Children with Attention Deficit Hyperactivity Disorder
    The Korean Association for Children with Special Needs ; 2009
    In:  The Journal of Special Children Education Vol. 11, No. 3 ( 2009-09), p. 391-411
    Details
    In: The Journal of Special Children Education, The Korean Association for Children with Special Needs, Vol. 11, No. 3 ( 2009-09), p. 391-411
    Type of Medium: Online Resource
    ISSN: 1229-8301
    URL: Journal
    URL: Article
    DOI: 10.21075/kacsn
    DOI: 10.21075/kacsn.2009.11.3.391
    Language: English
    Publisher: The Korean Association for Children with Special Needs
    Publication Date: 2009
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