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  • 1
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    Online Resource
    Survival After Development of Contralateral Breast Cancer in Korean Patients With Breast Cancer
    American Medical Association (AMA) ; 2023
    In:  JAMA Network Open Vol. 6, No. 9 ( 2023-09-14), p. e2333557-
    Details
    In: JAMA Network Open, American Medical Association (AMA), Vol. 6, No. 9 ( 2023-09-14), p. e2333557-
    Abstract: Contralateral breast cancer (CBC) is the most frequently diagnosed primary cancer in patients with breast cancer. Although many studies have reported survival after the development of CBC, results have been inconsistent. Objective To investigate whether the development of CBC is associated with survival among patients with breast cancer. Design, Setting, and Participants This cohort study was conducted at the Asan Medical Center, Korea, among patients who were diagnosed with primary unilateral, nonmetastatic, stage 0 to III breast cancer between 1999 and 2013 and followed up through 2018. The median (IQR) follow-up was 107 (75-143) months. Patients were categorized into CBC and no-CBC groups by whether they developed CBC during the follow-up period. Data were analyzed from November 2021 to March 2023. Exposure Development of CBC. Main outcomes and measures Survival rates of CBC and no-CBC groups were compared using a time-dependent Cox proportional hazard model in the entire study population and in subgroup analyses by interval of CBC development and subtype of the primary breast cancer. Results Among 16 251 patients with breast cancer (all Asian, specifically Korean; mean [SD] age, 48.61 [10.06] years), 418 patients developed CBC. There was no significant difference in overall survival between CBC and no-CBC groups (hazard ratio, 1.166; 95% CI, 0.820-1.657). Patients who developed CBC within 1.5 years after the surgery of the primary breast cancer had a higher risk for overall death during the study period (hazard ratio, 2.014; 95% CI, 1.044-3.886), and those who developed CBC after 1.5 years showed no significant difference in survival compared with the no-CBC group. Patients with hormone receptor (HR)–positive and human epidermal growth factor receptor 2 ( ERBB2 , formerly HER2)–negative breast cancer had a higher risk for overall death in the CBC group (hazard ratio, 1.882; 95% CI, 1.143-3.098) compared with the no-CBC group. Conclusions and Relevance This study found that development of CBC in patients with breast cancer was not associated with survival but that early development of CBC after diagnosis of the primary breast cancer or development of CBC in patients with HR-positive/ ERBB2 -negative breast cancer was associated with survival. These results may provide valuable information for patients seeking advice on opting for contralateral prophylactic mastectomy.
    Type of Medium: Online Resource
    ISSN: 2574-3805
    URL: Article
    DOI: 10.1001/jamanetworkopen.2023.33557
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2931249-8
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  • 2
    Online Resource
    Online Resource
    Abstract PO-051: Intracellular delivery of nuclear localization signal suppresses COVID-19 mediated inflammation by regulating expression of cytokines/chemokines
    American Association for Cancer Research (AACR) ; 2020
    In:  Clinical Cancer Research Vol. 26, No. 18_Supplement ( 2020-09-15), p. PO-051-PO-051
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 26, No. 18_Supplement ( 2020-09-15), p. PO-051-PO-051
    Abstract: The outbreak of coronavirus disease 19 (COVID-19), caused by the recently identified coronavirus named SARS-CoV-2, is leading patients to death (mortality: ~7%) because of cytokine storm. COVID-19 induces excessive secretion of proinflammatory cytokines and chemokines accompanied by the disruption of the bronchi and alveoli, which could ultimately develop into permanent lung impairments such as pulmonary fibrosis. To regulate the uncontrolled expression of proinflammatory cytokines/chemokines, improved cell-permeable nuclear import inhibitor (iCP-NI) has been developed by fusing sequence-optimized hydrophobic cell-penetrating peptide (CPP), namely advanced macromolecule transduction domain (aMTD) with nuclear localization signal (NLS) of stress responsive transcription factors (SRTFs: NF-κB, STAT1/3, AP-1, and NFAT). Intracellularly delivered NLS is supposed to suppress expression of proinflammatory cytokines/chemokines by inhibiting transport of SRTFs from cytoplasm into nucleus. iCP-NI regulated expression of cytokines (TNF-α: -79%, IL-6: -91%, IL-12: -110% and IL-10: +574%) and chemokines (MCP-1: -89%) in bronchoalveolar lavage fluids (BALFs) from RNA virus infection mimetic pneumonitis animals that were induced with inhalation of RNA structure molecule, poly I:C. iCP-NI also significantly decreased pulmonary fibrosis (-61%) in bleomycin-induced pulmonary fibrosis animals. Moreover, iCP-NI protected leukocytes (CD3+ T cell: 100%, CD4+/CD3+ T cell: 96%, B220+ B cell: 85%, CD45+ macrophage: 100%) and reduced apoptotic splenocytes (-97%) in staphylococcal enterotoxin B (SEB) and poly I:C-induced acute pneumonitis animals. These results suggest that iCP-NI has potential as a novel therapeutic measurement for inflammation caused by various infectious diseases including COVID-19 accompanied with cytokine storm and severe sepsis. Citation Format: Danbi Lee, Sanghyeon Yu, Misuk Baek, Jieun Kim, Mingu Kang, Hakyoung Park, Jaewook Lee, Seokwon Lee, Junghun Kwak, Hyemin Yu, Seungwoo Lee, Sujeong Kim, Hyewon Lee, Dasom Shin, Boram Kim, Minyoung Jung, Youngsil Choi, Daewoong Jo, Gyunam Kim, Dongho Kim. Intracellular delivery of nuclear localization signal suppresses COVID-19 mediated inflammation by regulating expression of cytokines/chemokines [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-051.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1557-3265.COVID-19-PO-051
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
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  • 3
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    Online Resource
    Effect of bathing on atopic dermatitis during the summer season
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Asia Pacific Allergy Vol. 2, No. 4 ( 2012-10), p. 269-274
    Details
    In: Asia Pacific Allergy, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 4 ( 2012-10), p. 269-274
    Type of Medium: Online Resource
    ISSN: 2233-8276
    URL: Article
    DOI: 10.5415/apallergy.2012.2.4.269
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    detail.hit.zdb_id: 2614800-6
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  • 4
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    Abstract P3-05-30: Survival after Development of Contralateral Breast Cancer
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 5_Supplement ( 2023-03-01), p. P3-05-30-P3-05-30
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 5_Supplement ( 2023-03-01), p. P3-05-30-P3-05-30
    Abstract: Purpose There are many studies reporting survival after development of contralateral breast cancer(CBC) but with inconsistent results. Also, many studies were based on European or North American population and few on Asian population. However, Korean breast cancer patients have different characteristics such as age distribution. Therefore, purpose of this study is to investigate whether development of CBC has influence on survival in Korean breast cancer population. Methods In this retrospective study, we included patients who were diagnosed with a first primary unilateral non-metastatic breast cancer at Asan Medical Center, Korea, between 1999-2013 followed through 2018. In this population, patients who delveloped CBC during the follow-up period were divided into the CBC cohort, and who did not into the non-CBC cohort. Survival of CBC cohort and non-CBC cohort was compared in the whole study population and in subgroup analysis by interval of CBC development, and breast cancer subtype. Results Over median follow-up of 107 months, 418 patients developed CBC out of 16,251 patients. Development of CBC did not influence overall survival or breast cancer-specific survival. In subgroup analysis by interval of CBC development, patients who developed CBC within one year after diagnosis of the first breast cancer had higher risk for overall death in CBC cohort (hazard ratio 2.58; 95% CI 1.28-5.18), and patients who developed CBC after one year showed no significant difference in survival compared with non-CBC cohort. In subgroup analysis by the subtype, patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative subtype for the first breast cancer showed higher risk for overall death in CBC cohort (hazard ratio 1.88; 95% CI 1.14-3.10) whereas patients with triple negative subtype for the first breast cancer showed lower risk for overall survival in CBC cohort (hazard ratio 0.42; 95% CI 0.19-0.95). Conclusion Development of CBC in Korean breast cancer patients did not have significant impact on survival. However, development of CBC early after diagnosis of first breast or having certain subtype of breast cancer may have affect on survival. Such information can be important information when counseling patients who are considering contralateral prophylactic mastectomy. Citation Format: Hakyoung Kim, Hee Jeong Kim, Yoon Tae In, Seonok Kim, Sae Byul Lee, Jisun Kim, Il-Yong Chung, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn. Survival after Development of Contralateral Breast Cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-05-30.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.SABCS22-P3-05-30
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 5
    Online Resource
    Online Resource
    Baseline neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in rectal cancer patients following neoadjuvant chemoradiotherapy
    SAGE Publications ; 2019
    In:  Tumori Journal Vol. 105, No. 5 ( 2019-10), p. 434-440
    Details
    In: Tumori Journal, SAGE Publications, Vol. 105, No. 5 ( 2019-10), p. 434-440
    Abstract: There is uncertainty over the effect of systemic inflammatory response on oncologic outcomes in patients who underwent neoadjuvant chemoradiotherapy and surgery for rectal cancer. We investigated the association between neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) as markers of systemic inflammation and tumor response and prognosis after treatment. Methods: A total of 176 patients who underwent neoadjuvant chemoradiotherapy and curative surgery for rectal cancer were analyzed retrospectively. Pretreatment hematologic parameters and the main clinical factors for patients and tumors were investigated with respect to their relationship with tumor regression and survival. Results: In the receiver operating characteristic analysis, NLR 2.0 and PLR 133.4 had the highest sensitivity and specificity in predicting tumor response. NLR 〈 2.0 and PLR 〈 133.4 were significantly correlated with good tumor response (odds ratio [OR] 2.490, 95% confidence interval [CI] 1.264–4.904, p = .008; OR 3.009, 95% CI 1.477–6.127, p 〈 .001). Patients with NLR 〈 2.0 had significantly better 5-year disease-free survival rate and overall survival rate compared to patients with NLR ⩾2.0 in multivariate analysis (86.8% vs 70.7%, p = .014; 92.4% vs 71.9%, p = .027). Conclusions: Elevated NLR and PLR levels can be considered as predictors of poor pathologic response, and NLR can be considered a prognosticator in patients who underwent neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/0300891618792476
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 6
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    Online Resource
    Pyrolysis of rice husk using CO 2 for enhanced energy production and soil amendment
    SAGE Publications ; 2023
    In:  Energy & Environment Vol. 34, No. 4 ( 2023-06), p. 873-885
    Details
    In: Energy & Environment, SAGE Publications, Vol. 34, No. 4 ( 2023-06), p. 873-885
    Abstract: Anthropogenic CO 2 generations from use of fossil resources has led to catastrophic climate problems. Biochar is a promising material for CO 2 capture and storage in soil, because it does not require additional storage space. To produce biochar, pyrolysis is required in an oxygen-limited condition. In an attempt to offer more environmentally benign route for biochar formation, this study introduced CO 2 as a reaction agent. Using rice husk as a model compound, biochars were produced under CO 2 and N 2 condition. Porosity of rice husk biochars (RHBs) were enhanced under CO 2 condition, because CO 2 affected to formation of nano-sized pores. pH and moisture retention capacity of garden soil was controlled with an addition of RHBs. Mixtures of garden soil and RHB were also used as cultivation media for growth of barley grass, and plant growth in the mixtures was improved by 20% comparing to garden soil. Moreover, CO 2 contributed to enhanced syngas generation during biochar production through gas phase reactions between CO 2 and volatile compounds. Thus, this study proved that CO 2 is a useful reactant for pyrolysis of biomass waste.
    Type of Medium: Online Resource
    ISSN: 0958-305X , 2048-4070
    URL: Article
    DOI: 10.1177/0958305X221079422
    RVK:
    AR 10100
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2027365-4
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  • 7
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    Online Resource
    Measurements of Isoprene and Monoterpenes at Mt. Taehwa and Estimation of Their Emissions
    Korean Society of Agricultural and Forest Meteorology ; 2015
    In:  Korean Journal of Agricultural and Forest Meteorology Vol. 17, No. 3 ( 2015-09-30), p. 217-226
    Details
    In: Korean Journal of Agricultural and Forest Meteorology, Korean Society of Agricultural and Forest Meteorology, Vol. 17, No. 3 ( 2015-09-30), p. 217-226
    Type of Medium: Online Resource
    ISSN: 1229-5671
    Uniform Title: 경기도 태화산에서 isoprene과 monoterpenes 측정 및 배출량 산정
    URL: Article
    DOI: 10.5532/KJAFM.2015.17.3.217
    Language: English
    Publisher: Korean Society of Agricultural and Forest Meteorology
    Publication Date: 2015
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  • 8
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    Online Resource
    Can we omit prophylactic inguinal nodal irradiation in anal cancer patients?
    Korean Society for Therapeutic Radiology and Oncology ; 2015
    In:  Radiation Oncology Journal Vol. 33, No. 2 ( 2015), p. 83-
    Details
    In: Radiation Oncology Journal, Korean Society for Therapeutic Radiology and Oncology, Vol. 33, No. 2 ( 2015), p. 83-
    Type of Medium: Online Resource
    ISSN: 2234-1900 , 2234-3156
    URL: Article
    DOI: 10.3857/roj.2015.33.2.83
    Language: English
    Publisher: Korean Society for Therapeutic Radiology and Oncology
    Publication Date: 2015
    detail.hit.zdb_id: 2712565-8
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  • 9
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    Estimation and Mapping of Methane Emission from Rice Paddies in Gyunggi-do Using the Modified Water Management Scaling Factor
    Korean Society of Agricultural and Forest Meteorology ; 2016
    In:  Korean Journal of Agricultural and Forest Meteorology Vol. 18, No. 4 ( 2016-12-30), p. 320-326
    Details
    In: Korean Journal of Agricultural and Forest Meteorology, Korean Society of Agricultural and Forest Meteorology, Vol. 18, No. 4 ( 2016-12-30), p. 320-326
    Type of Medium: Online Resource
    ISSN: 1229-5671
    Uniform Title: 수정된 물관리보정인자를 적용한 경기도 논에서의 메탄 배출량 산정과 지도화
    URL: Article
    DOI: 10.5532/KJAFM.2016.18.4.320
    Language: English
    Publisher: Korean Society of Agricultural and Forest Meteorology
    Publication Date: 2016
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  • 10
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    Leptomeningeal enhancement on preoperative brain MRI in patients with glioblastoma and its clinical impact
    Wiley ; 2018
    In:  Asia-Pacific Journal of Clinical Oncology Vol. 14, No. 5 ( 2018-10)
    Details
    In: Asia-Pacific Journal of Clinical Oncology, Wiley, Vol. 14, No. 5 ( 2018-10)
    Abstract: Leptomeningeal enhancement (LME) on preoperative brain magnetic resonance imaging (MRI) does not always indicate leptomeningeal seeding (LMS). With Stupp's regimen, authors have treated glioblastoma patients with LME on preoperative brain MRI but here we tried to find the clinical impact of LME. Methods From 2005 to 2015, 290 patients with glioblastoma have been treated with Stupp's regimen at Samsung Medical Center. Among these, 33 patients showed LME on preoperative brain MRI. We compared the clinical outcomes between the patients with or without LME on preoperative brain MRI and analyzed the clinical results according to changes of LME at following MRI. Results The median survival was 23 months, and 2‐year overall survival (OS) and disease‐free survival (DFS) rate was 46.3% and 19.6%, respectively. Prognostic factors for OS and DFS were Karnofsky performance status, extent of resection and adjuvant chemotherapy. MGMT promoter methylation status was a significant prognostic factor for DFS. However, LME was not a significant prognostic factor for OS ( P  = 0.156) or DFS ( P  = 0.193). Among the 33 patients with LME on preoperative MRI, 21 (63.6%) showed persistent LME at the next MRI. A statistically significant difference in 2‐year survival was evident between patients with and without persistent LME (OS, 17.3% and 70.1%, respectively, P  = 0.044; DFS, 5.3% and 54.0%, respectively, P  = 0.006). The most common pattern of failure was local recurrence. However, patients with persistent LME displayed a higher incidence of LMS than patients without LME. Conclusion LME on preoperative brain MRI did not affect the clinical results in glioblastoma patients treated with the Stupp's regimen. However, persistence of LME was associated with poor survival and high possibility of LMS. For these patients, the postoperative adjuvant treatment should focus on palliative aim or more aggressive treatment scheme should be followed to overcome the disastrous results.
    Type of Medium: Online Resource
    ISSN: 1743-7555 , 1743-7563
    URL: Issue
    URL: Article
    DOI: 10.1111/ajco.2018.14.issue-5
    DOI: 10.1111/ajco.12861
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2187409-8
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