In:
Journal of Medical Imaging and Radiation Oncology, Wiley, Vol. 60, No. 2 ( 2016-04), p. 274-282
Abstract:
The purpose of this study is to evaluate patterns of failure, overall survival ( OS ), disease‐free survival ( DFS ), prognostic factors and late toxicities in node positive I nternational F ederation of G ynaecology and O bstetrics ( FIGO ) stage IB cervix cancer treated with curative intent. Methods Patients with FIGO stage IB cervix cancer and positive nodes were identified from the P eter MacC allum C ancer C entre prospective gynaecology database. Patients were treated with primary surgery and adjuvant radiotherapy ( S + RT ) or primary radiotherapy (primary RT ). Prognostic factors examined were tumour size, histology, grade, lymphovascular invasion or corpus uterine invasion, MRI tumour volume, number of nodes involved, highest site of nodal involvement, treatment modality, age and smoking. Results Of the 103 eligible patients, 43 patients had S + RT and 60 patients had primary RT . Tumours were significantly smaller in the S + RT group (mean 3.0 cm vs. 4.5 cm, P 〈 0.001). Five‐year OS (95% confidence interval) and DFS (95% confidence interval) for the whole cohort was 67.6% (56.5–76.4%) and 66.1% (55.7–74.6%), respectively. Tumour diameter and number of positive nodes were significant prognostic factors for OS and DFS and smoking was related to DFS . Treatment modality was not a significant prognostic factor in OS and DFS . Of 33 patients that relapsed, 32 patients relapsed outside the pelvis. One patient failed in the pelvis only. Conclusions Early stage cervix cancer with nodal involvement is associated with excellent pelvic disease control following curative intent treatment. Almost all relapses occurred beyond the pelvis and therefore more aggressive local treatment is unlikely to improve survival in these patients.
Type of Medium:
Online Resource
ISSN:
1754-9477
,
1754-9485
DOI:
10.1111/jmiro.2016.60.issue-2
DOI:
10.1111/1754-9485.12411
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2409071-2
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