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  • 1
    Online Resource
    Online Resource
    Impact of macroeconomic factors on development of Paki-stan
    Science Publishing Corporation ; 2017
    In:  International Journal of Accounting and Economics Studies Vol. 5, No. 1 ( 2017-05-11), p. 63-
    Details
    In: International Journal of Accounting and Economics Studies, Science Publishing Corporation, Vol. 5, No. 1 ( 2017-05-11), p. 63-
    Abstract: Macroeconomic factors play a fundamental role in attracting the growth the country. This research examined the impact of various macroeconomic factors on GDP of Pakistan for the period of 1975-2015. The core objective of this research was to check the impact of inflation, investment, exchange rate and net export on development of Pakistan. The tool for analysis was Ordinary Least Square (OLS) multiple regression model. This research used Descriptive Statistics, Harvey's test for checking the heteroscedasticity and Breusch Godfrey LM test to check autocorrelation among variables. The results of this study show that inflation exerts negative significant effect on Pakistan GDP whereas investment shows positive significant effect and exchange rate have positive insignificant effect on GDP of Pakistan. Moreover net export has been highly positive significant on Pakistan GDP.
    Type of Medium: Online Resource
    ISSN: 2309-4508
    URL: Issue
    URL: Article
    DOI: 10.14419/ijaes.v5i1
    DOI: 10.14419/ijaes.v5i1.7538
    Language: Unknown
    Publisher: Science Publishing Corporation
    Publication Date: 2017
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    Online Resource
  • 2
    Online Resource
    Online Resource
    CEO Characteristics and Valuation of the Organization: A Quantile Regression Analysis
    Macrothink Institute, Inc. ; 2018
    In:  International Journal of Accounting and Financial Reporting Vol. 8, No. 1 ( 2018-03-14), p. 261-
    Details
    In: International Journal of Accounting and Financial Reporting, Macrothink Institute, Inc., Vol. 8, No. 1 ( 2018-03-14), p. 261-
    Abstract: This study examines the effects of three highly-visible CEO characteristics on a valuation of the organization. Using a sample for Chinese firms over the period of 2007-2016, we find that CEO age is consistently related with lower organizations’ valuation. CEO tenure is also related with lower valuation, but more significantly so in the higher quantiles of organizations’ valuation, that is for organizations with high growth opportunities. The CEO duality is found to be valuable only for organizations with high growth opportunities. Overall, this study highlights the contingent association between CEO characteristics and valuation of the organization.
    Type of Medium: Online Resource
    ISSN: 2162-3082
    URL: Issue
    URL: Article
    DOI: 10.5296/ijafr.v8i1
    DOI: 10.5296/ijafr.v8i1.12824
    Language: Unknown
    Publisher: Macrothink Institute, Inc.
    Publication Date: 2018
    detail.hit.zdb_id: 2640829-6
    SSG: 3,2
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    Online Resource
  • 3
    Online Resource
    Online Resource
    TMT Attention to Innovation of Organizations Influence the Organization Innovation Activities: Moderating Role of Corporate Governance
    Macrothink Institute, Inc. ; 2018
    In:  International Journal of Accounting and Financial Reporting Vol. 8, No. 1 ( 2018-03-28), p. 425-
    Details
    In: International Journal of Accounting and Financial Reporting, Macrothink Institute, Inc., Vol. 8, No. 1 ( 2018-03-28), p. 425-
    Abstract: This study examines the TMT attention to innovation influences an organizations innovation activities. The results show that the influence of executive attention to innovation on organizations innovation activities is moderated by the characteristics of corporate governance. This study develop and test the hypotheses imitative from the expectation of firm level data covering the period of 2012-2016. The result shows that TMTAI is positively related with an organization’s patent application, and that the positive association is stronger when an organizations is a state owned, has a large members of the board, and has a few independent directors.
    Type of Medium: Online Resource
    ISSN: 2162-3082
    URL: Issue
    URL: Article
    DOI: 10.5296/ijafr.v8i1
    DOI: 10.5296/ijafr.v8i1.12907
    Language: Unknown
    Publisher: Macrothink Institute, Inc.
    Publication Date: 2018
    detail.hit.zdb_id: 2640829-6
    SSG: 3,2
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Banking Sector Development, Inflation and Economic Growth in Asian Countries: A Panel Causality and Co-Integration Approach
    Macrothink Institute, Inc. ; 2018
    In:  International Journal of Accounting and Financial Reporting Vol. 8, No. 4 ( 2018-10-11), p. 384-
    Details
    In: International Journal of Accounting and Financial Reporting, Macrothink Institute, Inc., Vol. 8, No. 4 ( 2018-10-11), p. 384-
    Abstract: This study investigates the causal relationship between banking sector development, inflation, and economic growth for six Asian countries (Bangladesh, China, India, Malaysia, Pakistan and Sri Lanka) over the period of 1970-2016. Using a Pedroni panel, Kao co-integration test, Panel Granger causality-based Error Correction Model, Dynamic ordinary least square (DOLS), and Fully modified ordinary least square (FMOLS), this study finds that the development of the banking sector generally has a positive relationship with economic growth in the long-run. This results show that in the long-run, monetary policy play a vital role in the economic growth. This study also confirmed the response causality between the indicators of banking sector development and economic growth. Based on the empirical findings, this research provides important policy implications to the banking sector and economic supervisory bodies in order to achieve the long run economic growth.
    Type of Medium: Online Resource
    ISSN: 2162-3082
    URL: Issue
    URL: Article
    DOI: 10.5296/ijafr.v8i4
    DOI: 10.5296/ijafr.v8i4.14046
    Language: Unknown
    Publisher: Macrothink Institute, Inc.
    Publication Date: 2018
    detail.hit.zdb_id: 2640829-6
    SSG: 3,2
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Role of LGMN in tumor development and its progression and connection with the tumor microenvironment
    Frontiers Media SA ; 2023
    In:  Frontiers in Molecular Biosciences Vol. 10 ( 2023-2-7)
    Details
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 10 ( 2023-2-7)
    Abstract: Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic, and liver tumor cells, but also in the macrophages that compose the tumor microenvironment. This supports the idea that LGMN is a pivotal protein in regulating tumor development, invasion, and dissemination. Targeting LGMN with siRNA or chemotherapeutic medicines and peptides can suppress cancer cell proliferation in culture and reduce tumor growth in vivo . Furthermore, legumain can be used as a marker for cancer detection and targeting due to its expression being significantly lower in normal cells compared to tumors or tumor-associated macrophages (TAMs). Tumor formation is influenced by aberrant expression of proteins and alterations in cellular architecture, but the tumor microenvironment is a crucial deciding factor. Legumain (LGMN) is an in vivo-active cysteine protease that catalyzes the degradation of numerous proteins. Its precise biological mechanism encompasses a number of routes, including effects on tumor-associated macrophage and neovascular endothelium in the tumor microenvironment. The purpose of this work is to establish a rationale for thoroughly investigating the function of LGMN in the tumor microenvironment and discovering novel tumor early diagnosis markers and therapeutic targets by reviewing the function of LGMN in tumor genesis and progression and its relationship with tumor milieu.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    DOI: 10.3389/fmolb.2023.1121964
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2814330-9
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    Online Resource
  • 6
    Online Resource
    Online Resource
    TME-targeted approaches of brain metastases and its clinical therapeutic evidence
    Frontiers Media SA ; 2023
    In:  Frontiers in Immunology Vol. 14 ( 2023-5-9)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-5-9)
    Abstract: The tumor microenvironment (TME), which includes both cellular and non-cellular elements, is now recognized as one of the major regulators of the development of primary tumors, the metastasis of which occurs to specific organs, and the response to therapy. Development of immunotherapy and targeted therapies have increased knowledge of cancer-related inflammation Since the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCB) limit immune cells from entering from the periphery, it has long been considered an immunological refuge. Thus, tumor cells that make their way “to the brain were believed to be protected from the body’s normal mechanisms of monitoring and eliminating them. In this process, the microenvironment and tumor cells at different stages interact and depend on each other to form the basis of the evolution of tumor brain metastases. This paper focuses on the pathogenesis, microenvironmental changes, and new treatment methods of different types of brain metastases. Through the systematic review and summary from macro to micro, the occurrence and development rules and key driving factors of the disease are revealed, and the clinical precision medicine of brain metastases is comprehensively promoted. Recent research has shed light on the potential of TME-targeted and potential treatments for treating Brain metastases, and we’ll use that knowledge to discuss the advantages and disadvantages of these approaches.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2023.1131874
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2606827-8
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Mapping of familial hypercholesterolemia and dyslipidemias basic management infrastructure in Pakistan: a cross-sectional study
    Elsevier BV ; 2023
    In:  The Lancet Regional Health - Southeast Asia Vol. 12 ( 2023-05), p. 100163-
    Details
    In: The Lancet Regional Health - Southeast Asia, Elsevier BV, Vol. 12 ( 2023-05), p. 100163-
    Type of Medium: Online Resource
    ISSN: 2772-3682
    URL: Article
    DOI: 10.1016/j.lansea.2023.100163
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 3128823-6
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  • 8
    Online Resource
    Online Resource
    Factors affecting superovulation induction in goats (Capra hericus): An analysis of various approaches
    Frontiers Media SA ; 2023
    In:  Frontiers in Veterinary Science Vol. 10 ( 2023-3-24)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 10 ( 2023-3-24)
    Abstract: Goats are generally called a “poor man's cow” because they not only provide meat and milk but also other assistance to their owners, including skins for leather production and their waste, which can be used as compost for fertilizer. Multiple ovulation and embryo transfer (MOET) is an important process in embryo biotechnology, as it increases the contribution of superior female goats to breeding operations. The field of assisted reproductive biotechnologies has seen notable progress. However, unlike in cattle, the standard use of superovulation and other reproductive biotechnologies has not been widely implemented for goats. Multiple intrinsic and extrinsic factors can alter the superovulatory response, significantly restricting the practicability of MOET technology. The use of techniques to induce superovulation is a crucial step in embryo transfer (ET), as it accelerates the propagation of animals with superior genetics for desirable traits. Furthermore, the conventional superovulation techniques based on numerous injections are not appropriate for animals and are labor-intensive as well as expensive. Different approaches and alternatives have been applied to obtain the maximum ovarian response, including immunization against inhibin and the day-0 protocol for the synchronization of the first follicular wave. While there are several studies available in the literature on superovulation in cattle, research on simplified superovulation in goats is limited; only a few studies have been conducted on this topic. This review describes the various treatments with gonadotropin that are used for inducing superovulation in various dairy goat breeds worldwide. The outcomes of these treatments, in terms of ovulation rate and recovery of transferrable embryos, are also discussed. Furthermore, this review also covers the recovery of oocytes through repeated superovulation from the same female goat that is used for somatic cell nuclear transfer (SCNT).
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    DOI: 10.3389/fvets.2023.1152103
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2834243-4
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  • 9
    Online Resource
    Online Resource
    Investigating the teratogenic potential of diclofenac sodium on chick embryos: A warning for pregnant women
    Elsevier BV ; 2024
    In:  Toxicology Reports Vol. 12 ( 2024-06), p. 292-298
    Details
    In: Toxicology Reports, Elsevier BV, Vol. 12 ( 2024-06), p. 292-298
    Type of Medium: Online Resource
    ISSN: 2214-7500
    URL: Article
    DOI: 10.1016/j.toxrep.2024.02.010
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2805786-7
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Genetic resilience in chickens against bacterial, viral and protozoal pathogens
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-11-10)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-11-10)
    Abstract: The genome contributes to the uniqueness of an individual breed, and enables distinctive characteristics to be passed from one generation to the next. The allelic heterogeneity of a certain breed results in a different response to a pathogen with different genomic expression. Disease resistance in chicken is a polygenic trait that involves different genes that confer resistance against pathogens. Such resistance also involves major histocompatibility (MHC) molecules, immunoglobulins, cytokines, interleukins, T and B cells, and CD4+ and CD8+ T lymphocytes, which are involved in host protection. The MHC is associated with antigen presentation, antibody production, and cytokine stimulation, which highlight its role in disease resistance. The natural resistance-associated macrophage protein 1 (Nramp-1), interferon (IFN), myxovirus-resistance gene, myeloid differentiation primary response 88 (MyD88), receptor-interacting serine/threonine kinase 2 (RIP2), and heterophile cells are involved in disease resistance and susceptibility of chicken. Studies related to disease resistance genetics, epigenetics, and quantitative trait loci would enable the identification of resistance markers and the development of disease resistance breeds. Microbial infections are responsible for significant outbreaks and have blighted the poultry industry. Breeding disease-resistant chicken strains may be helpful in tackling pathogens and increasing the current understanding on host genetics in the fight against communicable diseases. Advanced technologies, such as the CRISPR/Cas9 system, whole genome sequencing, RNA sequencing, and high-density single nucleotide polymorphism (SNP) genotyping, aid the development of resistant breeds, which would significantly decrease the use of antibiotics and vaccination in poultry. In this review, we aimed to reveal the recent genetic basis of infection and genomic modification that increase resistance against different pathogens in chickens.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    DOI: 10.3389/fvets.2022.1032983
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2834243-4
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