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  • 1
    Online Resource
    Online Resource
    Pulse Oximeter Oxygen Saturation in Prediction of Arterial Oxygen Saturation in Liver Transplant Candidates
    Briefland ; 2014
    In:  Hepatitis Monthly Vol. 14, No. 3 ( 2014-03-17)
    Details
    In: Hepatitis Monthly, Briefland, Vol. 14, No. 3 ( 2014-03-17)
    Type of Medium: Online Resource
    ISSN: 1735-143X , 1735-3408
    URL: Journal
    URL: Article
    DOI: 10.5812/hepatmon
    DOI: 10.5812/hepatmon.15449
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2014
    detail.hit.zdb_id: 2236753-6
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  • 2
    Online Resource
    Online Resource
    〈p〉Parity as a Prognostic Factor in Patients with Advanced-Stage Epithelial Ovarian Cancer〈/p〉
    Informa UK Limited ; 2020
    In:  Cancer Management and Research Vol. Volume 12 ( 2020-02), p. 1447-1456
    Details
    In: Cancer Management and Research, Informa UK Limited, Vol. Volume 12 ( 2020-02), p. 1447-1456
    Type of Medium: Online Resource
    ISSN: 1179-1322
    URL: Journal
    URL: Article
    DOI: 10.2147/CMAR
    DOI: 10.2147/CMAR.S237073
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2508013-1
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  • 3
    Online Resource
    Online Resource
    Association between TLR2 and TLR4 Expression and Response to Induction Therapy in Acute Myeloid Leukemia Patients
    Knowledge E DMCC ; 2018
    In:  International Journal of Hematology-Oncology and Stem Cell Research ( 2018-10-22)
    Details
    In: International Journal of Hematology-Oncology and Stem Cell Research, Knowledge E DMCC, ( 2018-10-22)
    Abstract: Background: Toll-like receptors (TLRs) are a family of transmembrane pattern-recognition receptors that play a crucial role in the realization of innate and adaptive immune response. TLRs may play a role in tumor development and growth because of expression or up-regulation of functional TLRs in some tumors and tumor cell lines. The participation of TLRs in the pathogenesis of acute myeloid leukemia (AML) remains unspecified. This study aimed to investigate the effect of TLR2 and TLR4 expression in peripheral blood mononuclear cells of AML patients in response to induction chemotherapy. Materials and Methods: Eighty- five patients with newly diagnosed AML were evaluated. Using quantitative reverse transcriptase PCR, the mRNA expression of genes TLR2 and TLR4 was measured before starting and after induction chemotherapy. The differences in the mean expression levels of TLR2 and TLR4 before and after chemotherapy were compared using a paired t-test. The mean expression levels of TLR2 and TLR4 regarding laboratory data were analyzed by one-way ANOVA and Chi-square test. Results: We found that the mRNA expression of TLR2 after induction chemotherapy was significantly lower as compared to before treatment (p=0.001). Also, we found a lower TLR4 gene expression level after chemotherapy as compared to before chemotherapy, albeit it was not statistically significant (p=0.21). Moreover, we observed significantly higher expression of TLR2 and TLR4 in AML-M3 cases compared to non-M3 AML patients. Conclusion: The decreased expression of TLR4 in leukemic samples after induction chemotherapy might indicate a novel potential prognostic role for this receptor, particularly in AML-M3 cases.
    Type of Medium: Online Resource
    ISSN: 2008-2207
    URL: Article
    DOI: 10.18502/ijhoscr.v12i4.109
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2018
    detail.hit.zdb_id: 2652853-8
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  • 4
    Online Resource
    Online Resource
    Circulating MiR-1185¸ MiR-3183, and MiR-584 Levels in Plasma as Diagnostic Non-invasive Biomarkers for Early Detection of Breast Cancer
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Cancer Therapy Reviews Vol. 19 ( 2023-09-15)
    Details
    In: Current Cancer Therapy Reviews, Bentham Science Publishers Ltd., Vol. 19 ( 2023-09-15)
    Abstract: MicroRNAs (miRNAs) are non-coding RNA molecules with short sequences that function as main post-transcriptional gene regulators of different biological pathways via negative regulation of gene expression, thereby leading to either mRNA degradation or translational blockade. Dysregulated expression of these miRNAs has been related etiologically to many human diseases, including breast cancer. Various cellular processes of breast cancer progression, including cell proliferation, apoptosis, metastasis, recurrence and chemodrug resistance, are modulated by oncogenic miRNA (oncomiR). Objective: The objective of this investigation was to study the expression level and potential diagnostic/prognostic roles of circulating microRNAs (miR-3183, miR-1185, and miR-584) as novel breast cancer biomarkers. Method: The current study was conducted on 99 breast cancer (BC) female patients, aged between 20-63 years old, as the case group and 50 age-matched healthy females as control (HC). After microRNA extraction from the serum samples, real-time PCR was carried out for relative expression quantification of miR-1185, miR-3183a, and miR-584. The ROC curve analysis was performed to investigate the diagnostic value of miRNAs. Result: It was demonstrated that miRNA-1185, miRNA-584, and miRNA-3183 were significantly up-regulated (p-values 〈 0.0001) in female BC cases compared to the control group. Besides, based on the ROC analysis for BC versus HC, it was revealed that the AUC for miRNA-584 was 0.844 (95% confidence interval (CI) and could be proposed as a diagnostic biomarker for breast cancer screening and follow-up. Conclusion: MiRNAs expression profiling using blood-based samples demonstrated their upregulation in the serum and plasma and revealed the concept that circulating miRNAs have high potential as novel noninvasive biomarkers for cancer diagnosis and screening.
    Type of Medium: Online Resource
    ISSN: 1573-3947
    URL: Article
    DOI: 10.2174/1573394719666230915103139
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Micromorphology analysis and bond strength of two adhesives to Er,Cr:YSGG laser‐prepared vs. Bur‐prepared fluorosed enamel
    Wiley ; 2014
    In:  Microscopy Research and Technique Vol. 77, No. 10 ( 2014-10), p. 779-784
    Details
    In: Microscopy Research and Technique, Wiley, Vol. 77, No. 10 ( 2014-10), p. 779-784
    Abstract: Preservation of enamel during composite veneer restorations of fluorosed teeth could be achieved by conservative preparation with Erbium lasers. This study evaluated the effect of fluorosed enamel preparation with Er,Cr:YSGG vs. conventional diamond bur on the micromorphology and bond strength of a self‐etch and an etch‐and‐rinse adhesives. Er,Cr:YSGG laser or diamond bur preparation was performed on the flattened midbuccal surfaces of 70 extracted human premolars with moderate fluorosis (according to Thylstrup and Fejerskov index, TFI = 4–6). Adper Single Bond (SB) with acid etching for 20 or 40 s and Clearfil SE Bond (SEB) alone or with additional etching was applied in four laser groups. The same adhesive procedures were used in three bur groups except for 40 s of etching along with SB. After restoration, microshear bond strength was measured (MPa). Data were analyzed using ANOVA and Tamhane tests (α = 0.05). Six additional specimens were differently prepared and conditioned for scanning electron microscopy evaluation. The highest and lowest bond strengths were obtained for bur‐prepared/SB (39.5) and laser‐prepared/SEB (16.9), respectively, with a significant difference ( P  = 0.001). The different adhesive procedures used associated to two adhesives exhibited insignificantly lower bonding in laser‐prepared groups compared to bur‐prepared ones ( P   〉  0.05), with the exception of additional etching/SEB, which bonded significantly higher to bur‐prepared (36.4) than to laser‐prepared enamel (18.7, P  = 0.04). Morphological analyses revealed a delicate etch pattern with exposed enamel prisms on laser‐prepared fluorosed enamel after acid etching and less microretentive pattern after self‐etching primer. The etch‐and‐rinse adhesive was preferred in the laser‐prepared fluorosed enamel in terms of bonding performance. Microsc. Res. Tech. 77:779–784, 2014 . © 2014 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1059-910X , 1097-0029
    URL: Issue
    URL: Article
    DOI: 10.1002/jemt.v77.10
    DOI: 10.1002/jemt.22399
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1474912-9
    SSG: 11
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Change in Programmed Death-1 And Inducible Costimulator Expression in Patients with Acute Myeloid Leukemia Following Chemotherapy and Its Cytogenetic Abnormalities
    Salvia Medical Sciences Ltd ; 2022
    In:  Galen Medical Journal Vol. 11 ( 2022-12-31), p. e2394-
    Details
    In: Galen Medical Journal, Salvia Medical Sciences Ltd, Vol. 11 ( 2022-12-31), p. e2394-
    Abstract: Background: Programmed death-1 (PD-1) and inducible costimulator (ICOS) are immune checkpoint receptors participating in tumor immune evasion, which counters the activation signal provided through the T-cell receptor ligation. This study aimed to investigate the relationship between the expression of PD-1 and ICOS on mononuclear cells (MNCs) isolated from the peripheral blood of acute myeloid leukemia (AML) patients and their response to induction chemotherapy. Materials and Methods: Peripheral blood samples (5cc) were collected from 56 AML patients at first diagnosis before and after the induction therapy regimen for AML. PD-1 and ICOS expression were analyzed in all patients before and after the standard induction therapy regimen. Results: The expression of PD-1 and ICOS significantly decreased (66.7 and 16.3 fold, respectively) in AML patients following chemotherapy compared to its baseline value (P=0.01 and P=0.001, respectively). The expressions of PD-1 and ICOS were significantly different between favorable and poor risk groups. Conclusions: Lower PD-1 and ICOS expressions on the surface of MNCs before induction therapy were associated with a better response to treatments. In addition, PD-1 and ICOS expression on MNCs decreased after induction therapy.
    Type of Medium: Online Resource
    ISSN: 2322-2379 , 2588-2767
    URL: Article
    DOI: 10.31661/gmj.v11i.2394
    Language: Unknown
    Publisher: Salvia Medical Sciences Ltd
    Publication Date: 2022
    detail.hit.zdb_id: 2717170-X
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  • 7
    Online Resource
    Online Resource
    Conditional disease‐free survival rates and their associated determinants in patients with epithelial ovarian cancer: A 15‐year retrospective cohort study
    Wiley ; 2021
    In:  Cancer Reports Vol. 4, No. 6 ( 2021-12)
    Details
    In: Cancer Reports, Wiley, Vol. 4, No. 6 ( 2021-12)
    Abstract: The most common type of ovarian cancer (OC) is epithelial ovarian cancer (EOC) which is the most lethal gynecologic malignancy in adult women. Aim This study aimed to determine the conditional disease‐free survival (CDFS) rates and their associated determinants in patients with EOC. Methods and results The clinical and demographic data of 335 patients with confirmed EOC at Motahari Clinic (Shiraz, Iran) were retrospectively reviewed and analyzed. Traditional DFS (TDFS) and CDFS were calculated using the Kaplan–Meier method and cumulative DFS estimates, respectively. To evaluate the effects of the prognostic determinants on the DFS of the patients, a multiple covariate Cox analysis using the landmarking method was applied. The 1‐ and 3‐year TDFSs were 81.1% and 47.0%, respectively, and decreased over time. At baseline, a higher stage tumor and endometrioid histology were associated with a higher risk of recurrence when compared to stage I and other histological subtypes, respectively. The hazard of recurrence for older women (age ≥55 years) was approximately twice and three times more than that of women aged 〈 45 years at 1‐ and 3‐year landmark time points, respectively. Conclusion The age at diagnosis, defined by a cut‐off of 55 years, was a prognostic factor for the CDFS of EOC women. Moreover, patients with advanced‐stage EOC (ASEOC) (stages III and IV) and endometrioid histology had poorer CDFSs compared to those with early‐stage EOC (ESEOC) (stages I and II) and other histological types. In ESEOC patients with age at diagnosis of 〉 55 years, CDFS gradually decreased in 3 years after remission which should be considered for follow‐up care decision‐making.
    Type of Medium: Online Resource
    ISSN: 2573-8348 , 2573-8348
    URL: Issue
    URL: Article
    DOI: 10.1002/cnr2.v4.6
    DOI: 10.1002/cnr2.1416
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2920367-3
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