In:
Journal of Biomedical Materials Research Part A, Wiley, Vol. 80A, No. 4 ( 2007-03-15), p. 800-812
Abstract:
Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS‐ g ‐MPEG) and negatively charged hyaluronic acid (HA). CS‐ g ‐MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG‐aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS‐ g ‐MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS‐ g ‐MPEG solution. The highest viscosity was obtained when the charge ratio of CS‐ g ‐MPEG/HA was close to 1.0. Small‐angle X‐ray scattering measurements provided some insights into the lamellar structure of the CS‐ g ‐MPEG/HA complex. The CS‐ g ‐MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium). © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
Type of Medium:
Online Resource
ISSN:
1549-3296
,
1552-4965
DOI:
10.1002/jbm.a.v80a:4
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1477192-5
SSG:
12
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